Time-series photometry taken from ground-based facilities is improved with the use of comparison stars due to the short timescales of atmospheric-induced variability. However, the sky is bright in the thermal infrared (3-5 µm), and the correspondingly small fields-of-view of available detectors make it highly unusual to have a calibration star in the same field as a science target. Here we present a new method of obtaining differential photometry by simultaneously imaging a science target and a calibrator star, separated by 2 amin, onto a 10×10 asec 2 field-of-view detector. We do this by taking advantage of the LBT's unique binocular design to point the two co-mounted telescopes apart and simultaneously obtain both targets in three sets of observations. Results indicate that the achievable scatter in L S -band (λ c = 3.3 µm) is at the percent level for bright targets, and possibly better with heavier sampling and characterization of the systematics.