Scholars within the field of technical and professional communication (TPC) have called for situating the field in wider social, cultural, political, and global contexts. Despite a growing body of scholarship in this area, less attention has been focused on ways these issues are bound up in 21st-century global innovation and start-up ecosystems. This article addresses these issues by examining case studies of three high-tech initiatives in an emerging start-up ecosystem within the Occupied Palestinian Territory. In making this move, the research offers a theoretical and methodological framework for examining global innovation systems as they are constructed, enacted, maintained, extended, and transformed. Arguing for attention to the links between space and the politics of mobility, the author specifically examines the interplay of literacies, identities, technologies, mobilities, geographies, and practices.