Infratemporal fossa myoepithelial carcinoma—a rare case report

Ghosh, Anirban; Saha, Vedula Padmini; Sadhu, Anup; Chattopadhyay, S.

doi:10.1007/s10006-009-0149-5

Cited by 18 publications

(19 citation statements)

References 8 publications

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“…Histologically this tumor is well circumscribed, so complete excision is possible [18]. This neoplasm is not radio- or chemosensitive and it needs a long-term follow-up since recurrence varied from 35% to 50% and metastasis rates from 8.1% to 25% in different reports [19].…”

Section: Discussionmentioning

confidence: 99%

Myoepithelioma of the Nasal Septum: A Rare Case of Extrasalivary Gland Involvement

Cunha

Camurugy

Ribeiro

et al. 2017

Case Reports in Otolaryngology

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Introduction. The myoepithelioma is a rare benign tumor, most frequently found in the salivary glands. The extrasalivary gland involvement is even rarer and few cases involving the nasal cavity have been reported in the literature. Case Report. MES, a 54-year-old woman, complaining of progressive nasal obstruction and mild epistaxis through the right nostril which had developed 1 year previously. Computed tomography scan showed tumor with heterogeneous contrast enhancement occupying the right nasal cavity, moving contralaterally in the nasal septum. Excisional biopsy was performed through endoscopic surgery of the mass that was inserted at the nasal septum. Pathological and immunohistochemical exams concluded myoepithelioma. Discussion. The main symptoms of nasal myoepitheliomas are nasal obstruction and epistaxis. Immunohistochemistry is necessary to confirm the diagnosis, typically positive for cytokeratin and S-100, calponin, smooth muscle actin, myosin, vimentin, glial fibrillary acidic protein (GFAP), and carcinoembryonic antigen. The main marker for myoepithelioma is the S-100 protein. In our case, it was positive for cytokeratin, S-100, calponin, actin smooth muscle, and GFAP. In all cases reported in the literature surgical treatment was performed and the recurrence was associated with incomplete tumor resection. Final Comments. The myoepithelioma is a rare differential diagnosis of nasal tumors and its treatment is the total lesion excision.

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Section: Discussionmentioning

confidence: 99%

Myoepithelioma of the Nasal Septum: A Rare Case of Extrasalivary Gland Involvement

Cunha

Camurugy

Ribeiro

et al. 2017

Case Reports in Otolaryngology

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“…15 WHO classifies myoepithelial carcinoma as tumor composed almost exclusively of tumor cells with myoepithelial differentiation without luminal differentiation. 16,17 Currently, benign and malignant myoepi theliomas are differentiated by mitotic count, nuclear atypia, presence of invasive growth, cellular polymorphism, tumor necrosis, or their combination. 18 Myoepithelial carcinoma shows aggressiveness and recurrence even after adequate therapy, and is disproportionately common in pediatric age group having an aggressive clinical course.…”

Section: Discussionmentioning

confidence: 99%

Malignant Myoepithelial Carcinoma Expleomorphic Adenoma of the Hard Palate: An Aggressive Tumor with Diagnostic Dilemma

Naik¹,

Halkud²,

Siddappa³

et al. 2014

International Journal of Head and Neck Surgery

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Background/Objectives: Myoepithelial carcinomas are uncommon neoplasms that account for about 10% of all myoepitheliomas. The invasiveness varies from a locally aggressive to highly metastatic tumor which may arise de novo or in a pleomorphic adenoma. Myoepitheliomas arise from myoepithelial cells lacking ductal differentiation which exhibit both epithelial and smooth muscle cell elements.Case report: we report a case of palatal swelling excised 4 years back, as pleomorphic adenoma, which later recurred as malignant myoepithelial carcinoma expleomorphic adenoma of the palate. CECT of the paranasal air sinuses did not show any bony invasion of the hard palate. So he was given radical radiotherapy with concurrent chemotherapy but after 3 years developed recurrence and metastasis to the skin and the lungs. The patient was referred to oral chemotherapy on a palliative basis. Conclusion:Malignant myoepithelial carcinoma expleomorphic adenoma of the hard palate is a highly aggressive rare tumor of the hard palate. Radical management with surgery and adjuvant chemoradiotherapy improves survival in these patients. Followup with metastatic workup should be accurate as the tumor is highly aggressive with poor prognosis.

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“…Although it should be noted that two patients with low-grade tumors developed metastasis, of which one patient succumbed to the disease. MECA have, besides the mammary gland, also been described in the nasopharynx [4,5], lung [6], larynx [7,8], the infratemporal fossa [9], orbit [10] and skin [11][12][13].…”

Section: Discussionmentioning

confidence: 99%

Anaplastic Myoepithelial Carcinoma of the Sinonasal Tract: an Underrecognized Salivary-Type Tumor Among the Sinonasal Small Round Blue Cell Malignancies? Report of One Case and a Review of the Literature

Petersson

Chao

2010

Head and Neck Pathol

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We present a 45 year old female patient with a nasal carcinoma showing high-grade/anaplastic histomorphological features and with a distinct myoepithelial immunohistochemical phenotype including positivity for smooth muscle actin, p63, S100 protein with no sustentacular pattern, calponin, cytokeratin 14, vimentin and cytokeratins (AE1-3 and CK5/6). A minority (\5%) of the cells showed focal and variable immunoreactivity for EMA with no cuticular/canalicular pattern. Bcl-2, CD99, CD117 and CD56 were variously positive, but chromogranin and synaptophysin were negative. Weak to moderate nuclear p53 immunoreactivity was seen in 50% of tumor cells. Mib-1/Ki-67 showed an average proliferation of 60-70%. Fluorescent in situ hybridization revealed no EWS-gene translocation. In situ hybridization for EBER was negative.

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Infratemporal fossa myoepithelial carcinoma—a rare case report

Abstract: Here, a rare case of myoepithelial carcinoma arising from infratemporal fossa has been described along with its treatment options and outcome.

Cited by 18 publications

References 8 publications

Myoepithelioma of the Nasal Septum: A Rare Case of Extrasalivary Gland Involvement

Myoepithelioma of the Nasal Septum: A Rare Case of Extrasalivary Gland Involvement

Malignant Myoepithelial Carcinoma Expleomorphic Adenoma of the Hard Palate: An Aggressive Tumor with Diagnostic Dilemma

Anaplastic Myoepithelial Carcinoma of the Sinonasal Tract: an Underrecognized Salivary-Type Tumor Among the Sinonasal Small Round Blue Cell Malignancies? Report of One Case and a Review of the Literature

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