Ingestion of a protein hydrolysate is accompanied by an accelerated in vivo digestion and absorption rate when compared with its intact protein

Abstract

Ingestion of a protein hydrolysate, as opposed to its intact protein, accelerates protein digestion and absorption from the gut, augments postprandial amino acid availability, and tends to increase the incorporation rate of dietary amino acids into skeletal muscle protein.

Native whey induces higher and faster leucinemia than other whey protein supplements and milk: a randomized controlled trial

“…Protein hydrolysates are commonly produced by adding proteolytic enzymes, resulting in a complex mixture of peptides with differing lengths, and free amino acids [12]. Hydrolysed casein may be more rapidly digested than intact casein [7,13,14]. Grimble and colleges found that hydrolysing whey proteins to mainly di-and tri-peptides improved absorption in the perfused human jejunum [15], however, other studies did not find any effect on absorption rates by hydrolysing whey proteins [13,16] or a slowed absorption rate [17].…”

The muscle protein synthetic response to the combined ingestion of protein and carbohydrate is not impaired in healthy older men

“…As presented in previous works from our laboratory (Pennings et al 2011a, b;Pennings et al 2012;Koopman et al 2009a), we applied specifically produced intrinsically L-[1-…”

Role of Fermentable Carbohydrate Supplements in the Course of Uremia

“…The pre-dialytic parenteral nutrition seems to yield good results in order to preserve nutritional status (Cano et al, 1990), and it sounds to improve both morbidity and mortality on retrospective data (Capelli et al, 1994;Chertow et al, 1994). Others studies showed that the catabolism rate of AAs and net protein synthesis could be affected by the speed of protein digestion (Boirie et al, 1997, Koopman et al, 2009). Thus, soluble proteins of milk are more quickly oxidized and lead to a less efficience protein synthesis than casein.…”