Role of Fermentable Carbohydrate Supplements in the Course of Uremia

Younes, Hassan

doi:10.5772/26573

Cited by 1 publication

(2 citation statements)

References 102 publications

(95 reference statements)

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“…Fermentable carbohydrates might also modulate the excretion of nitrogen (N) metabolites by different mechanisms. They may stimulate the growth of certain members of the intestinal microbiota and therefore increase their requirement for N (Younes, 2012). In particular, they may use ammonia as source of N (Williams et al., 2001).…”

Section: Introductionmentioning

confidence: 99%

“…In particular, they may use ammonia as source of N (Williams et al., 2001). As a consequence, the microbial N fixation for bacterial protein synthesis increases the faecal N excretion (Younes, 2012). The microbial fermentation of some carbohydrates may also increase the concentration of lactic acid and therefore lower the pH in the digesta of the large intestine.…”

Section: Introductionmentioning

confidence: 99%

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Effects of dietary cellobiose on the intestinal microbiota and excretion of nitrogen metabolites in healthy adult dogs

Paßlack

Kohn

Vahjen

et al. 2021

Animal Physiology Nutrition

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In order to evaluate the potential prebiotic effects of cellobiose, 10 healthy adult research beagle dogs received a complete diet containing 0, 0.5 and 1 g cellobiose/kg bodyweight (BW)/day. At the end of each feeding period, faeces, urine and blood of the dogs were collected. The results demonstrated a significant increase of faecal lactate concentrations, indicating a bacterial fermentation of cellobiose in the canine intestine. Along with this, a dose-dependent linear increase of the relative abundance of Lactobacillaceae in the faeces of the dogs was observed (p = 0.014). In addition, a dosedependent increase (p < 0.05) of Alloprevotella, Bacteroides and Prevotella, and a linear decrease for unidentified Lachnospiraceae (p = 0.011) was observed when cellobiose was added to the diet, although the relative abundance of these genera was low (<1%) among all groups. The faecal pH was not affected by dietary cellobiose. Cellobiose seemed to modulate the excretion of nitrogen metabolites, as lower concentrations of phenol (p = 0.034) and 4-ethylphenol (p = 0.002) in the plasma of the dogs were measured during the supplementation periods. Urinary phenols and indoles, however, were not affected by the dietary supplementation of cellobiose. In conclusion, cellobiose seems to be fermented by the intestinal microbiota of dogs. Although no effect on the faecal pH was detected, the observed increase of microbial lactate production might lower the pH in the large intestine and consecutively modulate the intestinal absorption of nitrogen metabolites. Also, the observed changes of some bacterial genera might have been mediated by increased intestinal lactate concentrations or a higher relative abundance of lactobacilli. Whether these results could be considered as a prebiotic effect and used as a dietetic strategy in diseased animals to improve gut function or hepatic and renal nitrogen metabolism should be evaluated in future studies.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%