Ingestion of Chlorella Reduced the Oxidation of Erythrocyte Membrane Lipids in Senior Japanese Subjects

Miyazawa, Taiki; Nakagawa, Kiyotaka; Takekoshi, Hideo; Higuchi, Ohki; Kato, Shunji; Kondo, Momoko; Kimura, Fumiko; Miyazawa, Teruo

doi:10.5650/jos.62.873

Cited by 30 publications

(27 citation statements)

References 16 publications

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“…From the electronic searches, 1409 potential literature citations and four additional records identified through other sources were identified. In the end, a total of 27 RCTs (30 trials) with 1221 participants were finally considered to be selected for the current meta-analysis [ 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 ]. The characteristics of RCTs included in the meta-analysis are summarized in Table 1 .…”

Section: Resultsmentioning

confidence: 99%

Quantifying the Effect of Supplementation with Algae and Its Extracts on Glycolipid Metabolism: A Meta-Analysis of Randomized Controlled Trials

Ding

Gao

et al. 2020

Nutrients

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Aims: The effect of algae and its extract supplementation on glycolipid metabolism has not been finalized. Therefore, the purpose of the meta-analyses was to assess the effects of its supplementation on glycolipid metabolism concentration. Methods: We have systematically searched PubMed, Web of Science, the Cochrane Library and Embase to identify randomized controlled trials (RCTs) that investigated the impact of algae and its extracts supplementation on glycolipid metabolism. Effect size analysis was performed using weighted mean difference (WMD) and 95% CI between the methods of the experiment group and the control group. Subgroup analyses were performed to explore the possible influences of study characteristics. Publication bias and sensitivity analysis were also performed. Results: A total of 27 RCTs (31 trials) with 1221 participants were finally selected for the meta-analysis. The algae and its extract intervention significantly decreased glycosylated hemoglobin (HbA1c, WMD = −0.18%; 95% CI: −0.27 to −0.10; p < 0.001), high-density lipoprotein cholesterol (HDL-C, WMD = −0.22 mmol/L; 95% CI: −0.38 to −0.06; p = 0.008), and triglycerides (TC, WMD = −0.31 mmol/L; 95% CI: −0.37 to −0.25; p < 0.001) levels and increased insulin (WMD = 6.05 pmol/mL; 95% CI: 4.01 to 8.09; p < 0.001) levels. It did not significantly change the blood glucose, homeostasis model assessment-insulin resistance index (HOMA-IR), 2-h post-meal blood glucose (2hPBG) and other lipid profiles. Subgroup analyses based on the duration of intervention and subjects demonstrated that the intervention of algae and its extracts for 10 weeks or fewer and more than 40 subjects decreased TC levels (p < 0.05). Moreover, the intervention reduced TC and 2hPBG concentrations for East Asians (p < 0.05). Conclusions: Our findings provided evidence that algae and its extract interventions were beneficial for the regulation of human glycolipid metabolism. More precise RCTs on subjects are recommended to further clarify the effect of algae, seaweed polysaccharide, seaweed polypeptide, algae polyphenol and its products intervention on glycolipid metabolism.

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Section: Resultsmentioning

confidence: 99%

Quantifying the Effect of Supplementation with Algae and Its Extracts on Glycolipid Metabolism: A Meta-Analysis of Randomized Controlled Trials

Ding

Gao

et al. 2020

Nutrients

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“…Many natural products contain antioxidant molecules such as carotenoids, fl avonoids, polyphenols, ascorbic acid, and vitamin E, and supplementation with these can help to prevent peroxidative degeneration of plasma and tissue lipids (20)(21)(22). Persimmons are widely eaten in Japan and contain many benefi cial antioxidants.…”

Section: Discussionmentioning

confidence: 99%

Young Persimmon Ingestion Suppresses Lipid Oxidation in Rats

Fushimi

Miyazawa

Kimura

et al. 2015

J Nutr Sci Vitaminol

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“…When healthy pregnant women took 6 g/day of Chlorella tablets from gestational week 16-20 until the day of delivery, concentrations of antioxidants such as lutein, zeaxanthin and β-carotene in their breast milk were higher than those in the control group (Nagayama et al, 2014). Alzheimer's disease patients who took 8 g/day of Chlorella tablets for 2 months had lower erythrocyte phospholipid hydroperoxide concentrations than before supplementation (Miyazawa et al, 2013). In this way, Chlorella contributes to the health of humans through hypocholesterolemic action, carotenoid supplementation and antioxidant effects.…”

Section: Introductionmentioning

confidence: 92%

Safety evaluation of mutagenecity, acute and subacute toxicity study of <i>Chlorella vulgaris</i> CK-22 in rats

Himuro¹,

Ueno²,

Noguchi³

et al. 2014

Fundam. Toxicol. Sci.

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The aim of this study was to evaluate the safety of Chlorella vulgaris CK-22 as a food supplement. We examined mutagenicity, acute toxicity and subacute toxicity using Wistar rats administered Chlorella powder (CP). In the mutagenesis test, CP exhibited no mutagenecity in the in vitro assay. In the acute toxicity test, CP was administered orally at 0 mg/kg, 1,000 mg/kg, 2,000 mg/kg and 5,000 mg/kg body weight to Wistar rats (five animals/sex/group). No significance changes were observed test article-related during the 14-day observation period. The LD 50 of CP was estimated to be more than 5,000 mg/kg body weight in rats. In the subacute toxicity test, CP was administered at 0%, 2.5%, 5% and 10% in pelleted rodent diet to Wistar rats (ten animals/sex/groups). No mortality or treatment-related clinical signs were observed in any of the groups during the 28-day observation period. In both sexes, renal histopathology was conducted in the control and 10% groups, because absolute and relative renal weights increased in the 10% groups compared to the control groups. Based on the histopathology of the kidneys, the no-observed-adverse-effect level (NOAEL) is greater 8.57 g/kg body weight/day for males and 8.62 g/kg body weight/day for females.

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Ingestion of Chlorella Reduced the Oxidation of Erythrocyte Membrane Lipids in Senior Japanese Subjects

Cited by 30 publications

References 16 publications

Quantifying the Effect of Supplementation with Algae and Its Extracts on Glycolipid Metabolism: A Meta-Analysis of Randomized Controlled Trials

Quantifying the Effect of Supplementation with Algae and Its Extracts on Glycolipid Metabolism: A Meta-Analysis of Randomized Controlled Trials

Young Persimmon Ingestion Suppresses Lipid Oxidation in Rats

Safety evaluation of mutagenecity, acute and subacute toxicity study of <i>Chlorella vulgaris</i> CK-22 in rats

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