Ingestion of heat‐treated <i>Lactobacillus rhamnosus</i> GG prevents development of atopic dermatitis in NC/Nga mice

Sawada, Junko; Morita, Hirotsugu; Tanaka, Akane; Salminen, Seppo; He, Fang; Matsuda, Hiroshi

doi:10.1111/j.1365-2222.2006.02645.x

Cited by 94 publications

(86 citation statements)

References 43 publications

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“…GG has been shown to adjust t he Th/Th2 balance and induce IL-10 product ion dur ing allergic responses (Pessi et al 2000;Sawada et al 2007;Ghadimi et al 2008).…”

Section: Discussionmentioning

confidence: 99%

Anti‐allergic effects of Lactobacillus crispatus KT‐11 strain on ovalbumin‐sensitized BALB/c mice

Tobita

Yanaka²,

Otani

2010

Animal Science Journal

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In t his st udy, we invest igat ed t he effect s of oral ingest ion of Lactobacillus crispatus KT-11 stra in (KT-11) on t he immune response in an allergic rhinit is mouse model, ovalbumin (OVA)-sensit ized BALB/c. Sneezing act ivit y in mice that were administ ered a KT-11-supplement ed diet was significant ly lower than t hat in mice administ ered a KT-11-free diet (cont rol diet) at age of 11 weeks. We found t hat serum OVA-specific immunoglobulin E levels and tot al number of int er leukin (IL)

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“…GG has been shown to adjust t he Th/Th2 balance and induce IL-10 product ion dur ing allergic responses (Pessi et al 2000;Sawada et al 2007;Ghadimi et al 2008).…”

Section: Discussionmentioning

confidence: 99%

Anti‐allergic effects of Lactobacillus crispatus KT‐11 strain on ovalbumin‐sensitized BALB/c mice

Tobita

Yanaka²,

Otani

2010

Animal Science Journal

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“…Sawada et al reported that oral administration of heat-treated LAB (Lactobacillus rhamnosus GG) prevented the development of AD in NC/Nga mice, although there was no significant difference in the plasma total IgE level between the LAB administration group and the control group. They speculated that dermatitis in skin lesion and IgE level might not be regulated coincidentally and the LAB might drive dermatitis to normalize without regulating the IgE production in NC/Nga mice (34). On the other hand, Segawa et al reported that there was a high correlation between clinical score and serum total IgE level while oral administration of heat-treated LAB (Lactobacillus brevis SBC8803) significantly prevented the development of AD and serum total IgE elevation in NC/ Nga mice (35).…”

Section: Discussionmentioning

confidence: 99%

Oral Administration of Lactic Acid Bacteria Isolated from Traditional South Asian Fermented Milk `Dahi' Inhibits the Development of Atopic Dermatitis in NC/Nga Mice

Watanabe

Hamada

Tategaki

et al. 2009

J Nutr Sci Vitaminol

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SummaryWe investigated the suppressive effect of lactic acid bacteria (LAB) isolated from traditional South Asian fermented milk 'dahi' on the development of atopic dermatitis (AD) using NC/Nga AD model mice. In the initial evaluation, we confirmed the effect of LAB on serum total IgE using ovalbumin (OVA)-induced type 1 allergy model mice. Forty-one bacterial strains isolated from dahi were evaluated for their ability to induce interleukin (IL)-12 production and suppress IL-4 production in splenocytes obtained from OVA-sensitized mice. Of the 41 strains tested, Lactobacillus delbrueckii subsp. lactis R-037 exhibited the greatest IL-12 induction, suggesting that it is a potent Th1 inducer. Oral administration of heattreated R-037 significantly suppressed the elevation of serum total IgE in OVA-induced type 1 allergy model mice. In NC/Nga AD model mice, oral administration of heat-treated R-037 reduced inflammatory auricular thickness and alleviated the AD clinical score although the effect on serum total IgE level was unclear. Histopathological findings showed a tendency toward improvement of inflammation. Hyperkeratosis in particular showed improvement in dermatitis skin lesions. These results suggest that oral administration of R-037 may alleviate AD.

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“…Some components of heat-treated LGG may have an ability to delay the onset and suppress the development of atopic dermatitis, probably through a strong induction of IL-10 in intestinal lymphoid organs and systemic levels. 40 After probiotic consumption, LGG, Lactobacillus rhamnosus GG; LL, Lactococcus lactis; IFN-g, interferon-g; TGF-b, transforming growth factor-b; TLR, Toll-like receptor; ", increase in symptoms or negative effect; #, decrease in symptoms or positive effect; 1 , no change in symptoms or no effect. …”

Section: R E T R a C T E Dmentioning

confidence: 99%

RETRACTED: Preventative and Therapeutic Role of Probiotics in Various Allergic and Autoimmune Disorders: An Up-to-Date Literature Review of Essential Experimental and Clinical Data

Özdemir

2012

J Evid Based Complementary Altern Med

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“Preventative and Therapeutic Role of Probiotics in Various Allergic and Autoimmune Disorders: An Up-to-Date Literature Review of Essential Experimental and Clinical Data,” by Öner Özdemir, Journal of Evidence-Based Complementary & Alternative Medicine, April 2013 (18:2), doi: 10.1177/2156587212461279 .This article has been retracted due to unattributed overlap with material from other sources and due to duplicate publication.The unattributed excerpts in the article were taken from the following sources: Ouwehand AC. Antiallergic effects of probiotics. J Nutr. 2007;137(3 suppl 2):794S–797S. Saavedra JM. Use of probiotics in pediatrics: rationale, mechanisms of action, and practical aspects. Nutr Clin Pract. 2007;22:351–365. doi:10.1177/0115426507022003351. Rook GA, Brunet LR. Microbes, immunoregulation, and the gut. Gut. 2005;54:317–320. doi:10.1136/gut.2004.053785. Michail S. The role of probiotics in allergic diseases. Allergy Asthma Clin Immunol. 2009;5:5. doi:10.1186/1710-1492-5-5. The author also published the following works that include significant unattributed excerpts from the article: Özdemir Ö, Erol AY. Preventative and therapeutic probiotic use in allergic skin conditions: experimental and clinical findings. BioMed Res Int. 2013;2013:932391. doi:10.1155/2013/932391. Özdemir Ö. The role of probiotics in atopic dermatitis prevention and therapy. In: Esparza-Gordillo J, Dekio I, eds. Atopic Dermatitis: Disease Etiology and Clinical Management. Rijeka, Croatia: InTech; 2012:353–386. doi:10.5772/25301.

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Ingestion of heat‐treated Lactobacillus rhamnosus GG prevents development of atopic dermatitis in NC/Nga mice

Abstract: These findings suggest that some components of heat-treated L. GG may have an ability to delay the onset and suppress the development of atopic dermatitis, probably through a strong induction of IL-10 in intestinal lymphoid organs and systemic levels.

Cited by 94 publications

References 43 publications

Anti‐allergic effects of Lactobacillus crispatus KT‐11 strain on ovalbumin‐sensitized BALB/c mice

Anti‐allergic effects of Lactobacillus crispatus KT‐11 strain on ovalbumin‐sensitized BALB/c mice

Oral Administration of Lactic Acid Bacteria Isolated from Traditional South Asian Fermented Milk `Dahi' Inhibits the Development of Atopic Dermatitis in NC/Nga Mice

RETRACTED: Preventative and Therapeutic Role of Probiotics in Various Allergic and Autoimmune Disorders: An Up-to-Date Literature Review of Essential Experimental and Clinical Data

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