Ingestion of <i>Bifidobacterium longum</i> subspecies <i>infantis</i> strain CCFM687 regulated emotional behavior and the central BDNF pathway in chronic stress-induced depressive mice through reshaping the gut microbiota

Tian, Peijun; Zou, Renying; Li, Song; Zhang, Xu; Jiang, Bin; Wang, Gang; Lee, Yuan‐Kun; Zhao, Jianxin; Zhang, Hao; Chen, Wei

doi:10.1039/c9fo01630a

Cited by 72 publications

(60 citation statements)

References 41 publications

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“…CREB is up-regulated by chronic antidepressant treatment, and increasing CREB levels in rodent model results in antidepressant-like behaviors. Furthermore, postmortem studies indicate that CREB levels are increased in subjects taking antidepressants at the time of death (Tian et al, 2019). In agreement with that, the red wine extract treatment significantly increased the ratio of pCREB/CREB in the hippocampus and prefrontal cortex.…”

Section: Creb Phosphorylation/ Crebsupporting

confidence: 83%

Red wine polyphenols reverse depressive-like behaviors in mice induced by repeated corticosterone treatment

Yan

Sun

et al. 2019

Ciência Téc. Vitiv.

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The aim of this study was to investigate the antidepressant-like effect of red wine phenolic extracts in mouse model exposed to exogenous corticosterone. The results showed that 3-week corticosterone injections caused depression-like behavior in mice, as indicated by the significant decrease in sucrose consumption and increase immobility time in the forced swimming test (FST). Red wine phenolic extracts treatment significantly reduced serum corticosterone levels. Moreover, it was found that red wine phenolic extract increased the brain-derived neurotrophic factor protein (BNDF) and tropomyosin-related kinase B (TrkB) phosphorylation and cAMP-responsive element binding protein (CREB) phosphorylation levels in the hippocampus and prefrontal cortex. However, K252a, an inhibitor of TrkB, completely abolished those antidepressant-like effects. These results suggested that the red wine phenolic extracts produce an antidepressant-like effect in corticosteronetreated mice, at least in part, which is possibly mediated by modulating hypothalamic-pituitary-adrenal (HPA) axis, BDNF, TrkB and CREB phosphorylation levels in the brain region of mice.

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Section: Creb Phosphorylation/ Crebsupporting

confidence: 83%

Red wine polyphenols reverse depressive-like behaviors in mice induced by repeated corticosterone treatment

Yan

Sun

et al. 2019

Ciência Téc. Vitiv.

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“…With the increasing knowledge of the underlying mechanisms of AD, research has shifted from focusing on Aβ-driven pathologies to studying the role of neuroinflammatory factors during disease progression [ 26 , 27 ]. Probiotics can increase the concentrations of BDNF, growth factors and synaptic markers, and reduce neuroinflammation [ 28 ]. Thus, we next measured the concentrations of 12 different substances in the hippocampus of Aβ 1-42 -treated mice with or without B. breve intervention.…”

Section: Discussionmentioning

confidence: 99%

Administration of Bifidobacterium breve Improves the Brain Function of Aβ1-42-Treated Mice via the Modulation of the Gut Microbiome

et al. 2021

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Psychobiotics are used to treat neurological disorders, including mild cognitive impairment (MCI) and Alzheimer’s disease (AD). However, the mechanisms underlying their neuroprotective effects remain unclear. Herein, we report that the administration of bifidobacteria in an AD mouse model improved behavioral abnormalities and modulated gut dysbiosis. Bifidobacterium breve CCFM1025 and WX treatment significantly improved synaptic plasticity and increased the concentrations of brain-derived neurotrophic factor (BDNF), fibronectin type III domain-containing protein 5 (FNDC5), and postsynaptic density protein 95 (PSD-95). Furthermore, the microbiome and metabolomic profiles of mice indicate that specific bacterial taxa and their metabolites correlate with AD-associated behaviors, suggesting that the gut–brain axis contributes to the pathophysiology of AD. Overall, these findings reveal that B. breve CCFM1025 and WX have beneficial effects on cognition via the modulation of the gut microbiome, and thus represent a novel probiotic dietary intervention for delaying the progression of AD.

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“…It also increased the level of 5-hydroxytryptamine and brain-derived neurotrophic factor in the brain and decreased depressive behaviors [ 155 ]. Similarly, other studies using the same probiotics, found that treatment of chronically stressed mice with probiotics could restore gut microbiota perturbation, mitigate inflammation, and alleviate depression- and anxiety-like behaviors [ 156 , 157 ].…”

Section: Effect Of Probiotics On the Gut-brain Axis And Neuroinflamentioning

confidence: 85%

Probiotics in Treatment of Viral Respiratory Infections and Neuroinflammatory Disorders

et al. 2020

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Inflammation is a biological response to the activation of the immune system by various infectious or non-infectious agents, which may lead to tissue damage and various diseases. Gut commensal bacteria maintain a symbiotic relationship with the host and display a critical function in the homeostasis of the host immune system. Disturbance to the gut microbiota leads to immune dysfunction both locally and at distant sites, which causes inflammatory conditions not only in the intestine but also in the other organs such as lungs and brain, and may induce a disease state. Probiotics are well known to reinforce immunity and counteract inflammation by restoring symbiosis within the gut microbiota. As a result, probiotics protect against various diseases, including respiratory infections and neuroinflammatory disorders. A growing body of research supports the beneficial role of probiotics in lung and mental health through modulating the gut-lung and gut-brain axes. In the current paper, we discuss the potential role of probiotics in the treatment of viral respiratory infections, including the COVID-19 disease, as major public health crisis in 2020, and influenza virus infection, as well as treatment of neurological disorders like multiple sclerosis and other mental illnesses.

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Ingestion of Bifidobacterium longum subspecies infantis strain CCFM687 regulated emotional behavior and the central BDNF pathway in chronic stress-induced depressive mice through reshaping the gut microbiota

Abstract: Probiotics which enhance the biosynthesis of 5-hydroxytryptamine in enterochromaffin cells could alleviate depression symptoms through regulating the CREB-BDNF pathway in the brain.

Cited by 72 publications

References 41 publications

Red wine polyphenols reverse depressive-like behaviors in mice induced by repeated corticosterone treatment

Red wine polyphenols reverse depressive-like behaviors in mice induced by repeated corticosterone treatment

Administration of Bifidobacterium breve Improves the Brain Function of Aβ1-42-Treated Mice via the Modulation of the Gut Microbiome

Probiotics in Treatment of Viral Respiratory Infections and Neuroinflammatory Disorders

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