Ingestion of parsley inhibits the mutagenicity of male human urine following consumption of fried salmon

Ohyama, Shiro; Kitamori, Seiji; Kawano, Hiromi; Yamada, Teruki; Inamasu, Takeo; Ishizawa, Minoru; Ishinishi, Noburu

doi:10.1016/0165-7992(87)90118-7

Mutation Research Letters

1987

DOI: 10.1016/0165-7992(87)90118-7

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Ingestion of parsley inhibits the mutagenicity of male human urine following consumption of fried salmon

Shiro Ohyama

Seiji Kitamori

Hiromi Kawano

et al.

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Cited by 12 publications

References 10 publications

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Some perspectives on the nutritional aspects of breast cancer research. Food-derived heterocyclic amines as etiologic agents in human mammary cancer

Snyderwine¹

1994

Cancer

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Epidemiologic and experimental evidence indicates that dietary factors influence the incidence of mammary gland cancer. The dietary causes of this cancer, however, remain largely unknown. This paper reviews the experimental studies implicating the food‐derived heterocyclic amines (HAs) in human breast cancer. Heterocyclic amines are formed at the parts‐per‐billion levels in meats, such as beef, chicken, pork, and fish, cooked by ordinary methods. 2‐Amino‐1‐methyl‐6‐phenylimidazo [4, 5‐b]pyridine (PhIP) is among the most prevalent of the HAs in fried and barbecued beef, a staple of the American diet. Chronic administration of PhIP in the diet has been shown to cause mammary gland cancer in rats. Two other food‐derived HAs, 2‐amino‐3‐methylimidazo[4, 5‐flquinoline and 2‐amino‐3, 4‐dimethylimidazo[4, 5‐flquinoline, also have been shown to be mammary carcinogens in rodent models. In rats, heterocyclic amines produce DNA adducts in the mammary gland after metabolic activation. Studies examining human urine for HAs and metabolites confirm that humans who consume cooked meats are exposed to HAs. Studies also reveal that humans can activate HAs metabolically. Therefore, the experimental evidence suggests that the food‐derived HAs may be eliologic agents in human breast cancer. Humans, however, are exposed to a complex mixture of carcinogenic and anticarcinogenic agents through their diets. Experimental studies examining the interaction between HAs and other dietary factors with respect to mammary carcinugenesis are warranted.

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Some perspectives on the nutritional aspects of breast cancer research. Food-derived heterocyclic amines as etiologic agents in human mammary cancer

Snyderwine¹

1994

Cancer

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Antimutagenic activity of lettuce and chard extracts

Pérez

Gago

1991

Nahrung

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The ability of lettuce and chard extracts to reduce the mutagenic activity of Benzo[a]pyrene was studied. In this experiment several groups of male Balb/C mice were treated with different doses of the substances under study. B[a]p was administered at doses of 36 and 72 mg/kg of body weight to groups II and III, respectively. The lettuce extract combined with the doses of B[a]p were administered to groups IV and V. The experiment was performed again under the same conditions to test the effect of chard extract. Urine samples were tested by means of the Ames assay. The results show that the mutagenic activity of the urine samples from groups treated with B[a]p was reduced when the treatment also included any vegetable extract.

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Plant extracts as modulators of genotoxic effects

1996

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Ingestion of parsley inhibits the mutagenicity of male human urine following consumption of fried salmon

Cited by 12 publications

References 10 publications

Some perspectives on the nutritional aspects of breast cancer research. Food-derived heterocyclic amines as etiologic agents in human mammary cancer

Some perspectives on the nutritional aspects of breast cancer research. Food-derived heterocyclic amines as etiologic agents in human mammary cancer

Antimutagenic activity of lettuce and chard extracts

Plant extracts as modulators of genotoxic effects

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