Inguinal lymph node density as a powerful predictor of cancer specific survival in patients with node-positive penile cancer

Chavarriaga, Julian; Camacho, Diego; Suso-Palau, Daniel; Godoy, Fabián; Cabrera, Marino; Forero, Jorge; López-de-Mesa, Byron; Varela, Rodolfo

doi:10.1016/j.urolonc.2021.07.017

Cited by 5 publications

(5 citation statements)

References 13 publications

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“…14 Recent research underscores the relevance of inguinal lymph node density (LND) as a metric for risk stratification, particularly in penile cancer patients with positive lymph nodes who undergo inguinal lymph node dissection. 15 The TNM stage system serves as a widely employed tool for evaluating cancer prognosis, but it is not the best tool for any one group. In this study, the constructed nomogram was compared with the predictive model based on the TNM stage, and it was found that our model has a higher value than the TNM in the aspect of prognosis assessment for penile cancer patients.…”

Section: Discussionmentioning

confidence: 99%

“…While current treatments have boosted survival rates for about 80% of patients with early‐stage disease, those with inguinal lymph node metastases face drastically reduced 5‐year overall survival rates, dipping below 40% 14 . Recent research underscores the relevance of inguinal lymph node density (LND) as a metric for risk stratification, particularly in penile cancer patients with positive lymph nodes who undergo inguinal lymph node dissection 15 …”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Developing and validating a nomogram for penile cancer survival: A comprehensive study based on SEER and Chinese data

Luo,

Hu,

Mulati

et al. 2024

Cancer Medicine

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ObjectiveThe primary aim of this study was to create a nomogram for predicting survival outcomes in penile cancer patients, utilizing data from the Surveillance, Epidemiology, and End Results (SEER) and a Chinese organization.MethodsOur study involved a cohort of 5744 patients diagnosed with penile cancer from the SEER database, spanning from 2004 to 2019. In addition, 103 patients with penile cancer from Sun Yat‐sen Memorial Hospital of Sun Yat‐sen University were included during the same period. Based on the results of regression analysis, a nomogram is constructed and validated internally and externally. The predictive performance of the model was evaluated by concordance index (c‐index), area under the curve, decision curve analysis, and calibration curve, in internal and external datasets. Finally, the prediction efficiency is compared with the TNM staging model.ResultsA total of 3154 penile patients were randomly divided into the training group and the internal validation group at a ratio of 2:1. Nine independent risk factors were identified, including age, race, marital status, tumor grade, histology, TNM stage, and the surgical approach. Based on these factors, a nomogram was constructed to predict OS. The nomogram demonstrated relatively better consistency, predictive accuracy, and clinical relevance, with a c‐index over 0.73 (in the training cohort, the validation cohort, and externally validation cohort.) These evaluation indexes are far better than the TNM staging system.ConclusionPenile cancer, often overlooked in research, has lacked detailed investigative focus and guidelines. This study stands as the first to validate penile cancer prognosis using extensive data from the SEER database, supplemented by data from our own institution. Our findings equip surgeons with an essential tool to predict the prognosis of penile cancer better suited than TNM, thereby enhancing clinical decision‐making processes.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Developing and validating a nomogram for penile cancer survival: A comprehensive study based on SEER and Chinese data

Luo,

Hu,

Mulati

et al. 2024

Cancer Medicine

View full text Add to dashboard Cite

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“…From the Memorial Sloan–Kettering Cancer Center surgical database between January 1995 and September 2011, the 3-year CSS rates of patients with positive, negative, and unknown LNM status were 90%, 65%, and 86%, respectively ( p = 0.03) [ 18 ]. Previous studies of the prognosis of PSCC demonstrated that the histopathological characteristics of inguinal LNs, including the number of positive nodes, LN density, and PLNM, are predictive factors associated with CSS [ 8 , 18 , 19 , 20 , 21 , 22 ]. Based on the report from the Istituto Nazionale Tumori, the LN ratio (LNR) was an important prognostic parameter in a contemporary population of patients who underwent surgical treatment for PSCC and LNM [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

“…The 2- and 5-year CSS rates were 79.1% and 65.2% for patients with an LNR <22% and 35.9% and 9.6% for those with an LNR ≥22% ( p < 0.001) [ 8 ]. Patients with PSCC with an LN density >20% had an increased risk of recurrence or progression in the univariate (hazard ratio (HR), 2.12; 95% confidence interval (CI), 1.18–3.80; p = 0.011) and multivariate (HR, 2.32; 95% CI, 1.21–4.45; p = 0.011) analyses [ 19 ]. Yu et al reported that the CSS of patients with PSCC with an LNR >0.23% was significantly worse than that of those with an LNR ≤0.23% [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

Clinical Lymph Node Involvement as a Predictor for Cancer-Specific Survival in Patients with Penile Squamous Cell Cancer

et al. 2022

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We aimed to identify prognostic predictive factors of patients with penile squamous cell carcinoma (PSCC). This retrospective study reviewed the clinical and pathological data of patients with PSCC at 10 institutions in Japan between January 2008 and December 2019. The primary endpoint was cancer-specific survival (CSS). We also identified useful predictive factors for CSS in patients with PSCC. In total, 64 patients with PSCC were enrolled. At the end of the follow-up period, 15 patients (23.4%) died owing to PSCC and six (9.4%) died owing to other causes. The 2- and 3-year CSS rates were 78.9% and 76.6%, respectively. Using the Kaplan–Meier method, the Eastern Cooperative Oncology Group performance status 0, serum albumin levels ≥4.2 g/dL, hemoglobin levels ≥13.2 g/dL, C-reactive protein levels <0.21 mg/dL, clinical T stage ≤2, clinically negative lymph node (LN) status, and tumor size <30 mm were associated with a significantly better CSS. In the multivariate analysis, the clinically positive LN status was a significant predictive factor for CSS in patients with PSCC. Further prospective large-scale and long-term studies are required to validate our findings.

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Development and validation of a predictive model for penile cancer based on the surveillance, epidemiology, and end results database and multi-center cases

Yang

Chang

Zhang

et al. 2023

J Cancer Res Clin Oncol

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Inguinal lymph node density as a powerful predictor of cancer specific survival in patients with node-positive penile cancer

Cited by 5 publications

References 13 publications

Developing and validating a nomogram for penile cancer survival: A comprehensive study based on SEER and Chinese data

Developing and validating a nomogram for penile cancer survival: A comprehensive study based on SEER and Chinese data

Clinical Lymph Node Involvement as a Predictor for Cancer-Specific Survival in Patients with Penile Squamous Cell Cancer

Development and validation of a predictive model for penile cancer based on the surveillance, epidemiology, and end results database and multi-center cases

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