Inhalable liposomal formulation for vasoactive intestinal peptide

Hajos, Franz; Stark, Brigitte; Hensler, Sigrid; Ruth, Peter; Mosgoeller, Wilhelm

doi:10.1016/j.ijpharm.2008.01.046

Cited by 63 publications

(25 citation statements)

References 37 publications

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“…Liposomes have also been extensively studied for the delivery of peptides and proteins. Amphipathic or hydrophilic biological molecules could be encapsulated within the liposomal central aqueous cores [82,83]. Hydrophobic amino acid residues within the primary sequence of protein/peptide, on the other hand, may insert into the lipid bilayers to interact with lipid acyl chains by hydrophobic interaction [25].…”

Section: Delivery Of Peptide and Protein Drugsmentioning

confidence: 99%

Improvement of drug safety by the use of lipid-based nanocarriers

Lim

Banerjee

Önyüksel

2012

Journal of Controlled Release

274

142

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Section: Delivery Of Peptide and Protein Drugsmentioning

confidence: 99%

Improvement of drug safety by the use of lipid-based nanocarriers

Lim

Banerjee

Önyüksel

2012

Journal of Controlled Release

274

142

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“…131 Current drug delivery systems have demonstrated an ability to achieve sustained release locoregionally, but further improvement is welcomed. 40,48,252 Nevertheless, the timing of the drug administration has to be shortened. 30,48 Additional modifications were made to the molecules, to include targeted therapies, such as the epidermal growth factor receptor.…”

Section: Resultsmentioning

confidence: 99%

Inhaled chemotherapy in lung cancer: future concept of nanomedicine

Zarogoulidis

Chatzaki²,

Porpodis³

et al. 2012

IJN

168

160

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Regional chemotherapy was first used for lung cancer 30 years ago. Since then, new methods of drug delivery and pharmaceuticals have been investigated in vitro, and in animals and humans. An extensive review of drug delivery systems, pharmaceuticals, patient monitoring, methods of enhancing inhaled drug deposition, safety and efficacy, and also additional applications of inhaled chemotherapy and its advantages and disadvantages are presented. Regional chemotherapy to the lung parenchyma for lung cancer is feasible and efficient. Safety depends on the chemotherapy agent delivered to the lungs and is dose-dependent and time-dependent. Further evaluation is needed to provide data regarding early lung cancer stages, and whether regional chemotherapy can be used as neoadjuvant or adjuvant treatment. Finally, inhaled chemotherapy could one day be administered at home with fewer systemic adverse effects.

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“…Using ex-vivo lung model, it was demonstrated that liposome loaded VIP interacted with its receptor and induced significantly higher vasodilation as compared to free VIP. Later, Hajos et al [125] evaluated applicability of liposomal VIP for inhalation purposes using commercially available inhaler Micro Drop Master Jet (MPV Truma, Putzbrunn, Germany). Results demonstrated that liposomes were stable after nebulization, as no sign of liposomal degradation and aggregation were found.…”

Section: Accepted Manuscriptmentioning

confidence: 99%