Inhalants

Bowen, Scott E.; Cruz, Silvia L.

doi:10.1016/b978-0-12-418679-8.00018-6

Cited by 6 publications

(2 citation statements)

References 118 publications

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“…1 Inhalants recognized to have abuse potential are found in thousands of registered products. 2 –5 While historically the misuse of inhalants was confined primarily to males, usage among females has increased to the point that at several ages, the abuse of volatile substances is now greater in females than in males of the same age. 6,7 As abuse of volatile substances is known to progress into adulthood, abuse by women in their reproductive years may also be increasing, 8 –10 elevating concerns of the potential detrimental effects of intentionally inhaled organic solvents on the developing fetus.…”

Section: Introductionmentioning

confidence: 99%

“…As mentioned above, the field of volatile substance abuse research comprises many different substances including solvents, volatile anesthetics, nitrites, fuels, and so on. 3,4,30 However, this review limited itself specifically to toluene misuse for the simple reason that toluene is by far the most commonly studied abused inhalant. To that end, there are several proposed moderators that may explain the observed discrepancies.…”

Section: Introductionmentioning

confidence: 99%

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Changes in developmental body weight as a function of toluene exposure

et al. 2015

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Inhalant abuse is a globally prevalent health issue with particular concerns about substance-abusing pregnant women. In both animal models and clinical case reports of toluene exposure, the primary physiological outcome measure of prenatal inhalant exposure is low birth weight (BW). However, the effect of prenatal toluene exposure on animal BW varies widely in the literature. To clarify this effect and investigate possible design moderators of pup BW, a systematic review and meta-analytic techniques were applied to the existing peer-reviewed animal literature of prenatal and postnatal exposure models to the inhaled solvent toluene. Of 288 studies screened, 24 studies satisfied the inclusion criteria. Evaluation of these studies indicated that toluene exposure was negatively associated with pup BW ( d = −0.39), with external inhaled concentration, route of administration, day of weighing, and toluene exposure magnitude moderating this association. Investigators doing animal studies should be cognizant of these factors before investigating the reproductive and developmental outcomes associated with prenatal and postnatal toluene exposure.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Changes in developmental body weight as a function of toluene exposure

et al. 2015

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Inhalant Addiction

Real¹,

Cruz²,

Medina‐Mora³

2014

Textbook of Addiction Treatment: International Perspectives

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Striatal dopamine dynamics in mice following acute and repeated toluene exposure

2014

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These voltammetric neurochemical findings following repeated toluene exposure suggest that there may be a compensatory downregulation of the DA system. Acute or repeated toluene exposure had no effect on the DA uptake kinetics. Taken together, these results demonstrate that acute toluene inhalation potentiates DA release, while repeated toluene exposure attenuates DA release in the nucleus accumbens only.

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Inhalants

Cited by 6 publications

References 118 publications

Changes in developmental body weight as a function of toluene exposure

Changes in developmental body weight as a function of toluene exposure

Inhalant Addiction

Striatal dopamine dynamics in mice following acute and repeated toluene exposure

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