Inhalation of Atmospheric-Pressure Gas Plasma Attenuates Brain Infarction in Rats With Experimental Ischemic Stroke

Interactions of floating potential on metal and dielectric targets with He atmospheric pressure plasma jet (APPJ) were studied in this paper. The APPJ is generated in a needle-ring corona-dielectric barrier discharge configuration, driven by a sinusoidal voltage. The characteristics of APPJ were assessed through electrical and optical examinations, and the time-average electrostatic voltage on the targets was measured using both contact and non-contact electrostatic voltmeters. It was found that both metal and dielectric targets can promote the jet development and speed up the jet velocity. During the negative half-cycle, the “plasma cluster” propagates from the target toward the ground electrode and then “merges” with the forward plasma jet, leading to a reversed development of jet. The two targets follow a similar pattern on the surface electrostatic voltage, that is, initially in a positive polarity whose amplitude first increases and then decreases and transits to negative polarity with an increase in the applied voltage. But there are also some minor differences between the two targets, e.g., the metallic target can change the discharge pattern and reduces the discharge current under certain conditions.

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Enhanced Neural Recovery and Reduction of Secondary Damage in Spinal Cord Injury through Modulation of Oxidative Stress and Neural Response

Zhu,

Liu,

Liu

et al. 2024

Preprint

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Spinal cord injury (SCI) presents a critical medical challenge, marked by substantial neural damage and persistent functional deficits. This study investigates the therapeutic potential of cold atmospheric plasma (CAP) for SCI, utilizing a tailored dielectric barrier discharge (DBD) device to conduct comprehensive in vivo and in vitro analyses. The findings show that CAP treatment significantly improves functional recovery after SCI, reduces neuronal apoptosis, lowers inflammation, and increases axonal regeneration. These findings illustrate the efficacy of CAP in fostering a conducive environment for recovery by modulating inflammatory responses, enhancing neuronal survival, and encouraging regenerative processes. The underlying mechanism involves CAP's reduction of reactive oxygen species (ROS) levels, followed by the activation of antioxidant enzymes. These findings position CAP as a pioneering approach for spinal cord injury (SCI) treatment, presenting opportunities for improved neural recovery and establishing a new paradigm in SCI therapy.

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Inhalation of Atmospheric-Pressure Gas Plasma Attenuates Brain Infarction in Rats With Experimental Ischemic Stroke

Cited by 4 publications

References 47 publications

Enhanced neural recovery and reduction of secondary damage in spinal cord injury through modulation of oxidative stress and neural response

Enhanced neural recovery and reduction of secondary damage in spinal cord injury through modulation of oxidative stress and neural response

Interaction between atmospheric pressure plasma jet and target

Enhanced Neural Recovery and Reduction of Secondary Damage in Spinal Cord Injury through Modulation of Oxidative Stress and Neural Response

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