Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia–reperfusion injury

Hayashida, Kentaro; Sano, Motoaki; Ohsawa, Ikuroh; Shinmura, Ken; Tamaki, Kunihiko; Kimura, Kensuke; Endo, Jin; Katayama, Takaharu; Kawamura, Akio; Kohsaka, Shun; Makino, Shinji; Ohta, Shigeo; Ogawa, Satoshi; Fukuda, Keiichi

doi:10.1016/j.bbrc.2008.05.165

Cited by 434 publications

(318 citation statements)

References 24 publications

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“…We undertook experiments in rats2 and dogs3 with Professor Shigeo Ohta from the Nippon Medical School (Tokyo, Japan) and Dr. Masafumi Kitakaze from the National Cerebral and Cardiovascular Center (Osaka, Japan), which verified that inhalation of 1–4% hydrogen gas alleviated tissue damage and reduced the infarct size. An investigator‐initiated clinical trial to assess the safety and efficacy of inhaled hydrogen gas for the prevention of reperfusion injury in patients with acute MI undergoing percutaneous coronary intervention was started at Keio University Hospital (Tokyo, Japan) in December 2011 (UMIN Clinical Trials Registry number: UMIN000006825).…”

Section: Clinical Evidencementioning

confidence: 86%

Promising novel therapy with hydrogen gas for emergency and critical care medicine

Sano

Suzuki

Homma

et al. 2017

Acute Medicine & Surgery

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It has been reported that hydrogen gas exerts a therapeutic effect in a wide range of disease conditions, from acute illness such as ischemia–reperfusion injury, shock, and damage healing to chronic illness such as metabolic syndrome, rheumatoid arthritis, and neurodegenerative diseases. Antioxidant and anti‐inflammatory properties of hydrogen gas have been proposed, but the molecular target of hydrogen gas has not been identified. We established the Center for Molecular Hydrogen Medicine to promote non‐clinical and clinical research on the medical use of hydrogen gas through industry–university collaboration and to obtain regulatory approval of hydrogen gas and hydrogen medical devices (http://www.karc.keio.ac.jp/center/center-55.html). Studies undertaken by the Center have suggested possible therapeutic effects of hydrogen gas in relation to various aspects of emergency and critical care medicine, including acute myocardial infarction, cardiopulmonary arrest syndrome, contrast‐induced acute kidney injury, and hemorrhagic shock.

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Section: Clinical Evidencementioning

confidence: 86%

Promising novel therapy with hydrogen gas for emergency and critical care medicine

Sano

Suzuki

Homma

et al. 2017

Acute Medicine & Surgery

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“…Recently, molecular hydrogen (H 2 ) has been shown to be a novel therapeutic antioxidant by reducing detrimental ROS [11,12,13,14,15,16,17,18]. Results of previous studies showed that inhalation of H 2 gas efficiently protected against organ damage such as ischemia-reperfusion injury in the brain [11,12], liver [13], heart [14] and lungs [15], as well as experimental sepsis [16,17] in rodents.…”

Section: Introductionmentioning

confidence: 99%

Inhalation of Hydrogen Gas Is Beneficial for Preventing Contrast-Induced Acute Kidney Injury in Rats

Homma

Yoshida²,

Yamashita³

et al. 2015

Nephron Exp Nephrol

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Background: The present study aimed at investigating the effect of a novel antioxidant, hydrogen (H₂) gas, on the severity of contrast-induced acute kidney injury (CIAKI) in a rat model. Methods: CIAKI was induced in rats by intravenous injection of a contrast medium, Ioversol, in addition to reagents inhibiting prostaglandin and nitric oxide synthesis. During the injection of these reagents, the rats inhaled H₂ gas or control gas. Results: One day after the injection, serum levels of urea nitrogen were significantly lower in H₂ gas-inhaling CIAKI rats (17.6 ± 2.3 mg/dl) than those in control gas-treated CIAKI rats (36.0 ± 7.3 mg/dl), although they both were elevated as compared to untreated rats (14.9 ± 0.9 mg/dl). Consistently, creatinine clearance in H₂ gas-treated CIAKI rats was higher than that in control gas-treated counterparts. Renal histological analysis revealed that the formation of proteinaceous casts and tubular necrosis was improved by H₂ gas inhalation. Mechanistic analyses showed that inhalation of H₂ gas significantly reduced renal cell apoptosis, expression of cleaved caspase 3, and expression of an oxidative stress marker, 8-hydroxydeoxyguanosine, in injured kidneys. Conclusion: Results suggest that H₂ gas inhalation is effective in ameliorating the severity of CIAKI in rats by reducing renal cell apoptosis and oxidative stress.

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“…27) Many papers have reported that molecular hydrogen improves the state of oxidative stress-related disease model animals. [28][29][30][31][32] Sato et al 33) reported that hydrogen molecules suppress superoxide anion radical formation in brain slices of mice. As shown in Table 1, the ERW used in the present study contained high concentrations of molecular hydrogen, but the concentration rapidly decreased to less than 50 ppb (25 mM) during the pH adjustment.…”

Section: Discussionmentioning

confidence: 99%

Extension of the Lifespan ofCaenorhabditis elegansby the Use of Electrolyzed Reduced Water

Yan

Tian

Kinjo

et al. 2010

Bioscience, Biotechnology, and Biochemistry

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Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia–reperfusion injury

Cited by 434 publications

References 24 publications

Promising novel therapy with hydrogen gas for emergency and critical care medicine

Promising novel therapy with hydrogen gas for emergency and critical care medicine

Inhalation of Hydrogen Gas Is Beneficial for Preventing Contrast-Induced Acute Kidney Injury in Rats

Extension of the Lifespan ofCaenorhabditis elegansby the Use of Electrolyzed Reduced Water

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