Inhalation toxicology of ammonium persulfate, an oxidant aerosol, in rats

Dasgupta, Purnendu Κ.; DeCesare, Kymron B.; Tarkington, Brian K.

doi:10.1016/0041-008x(82)90047-3

Cited by 15 publications

(6 citation statements)

References 22 publications

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“…The present results are partially in accordance with the experiments of LAST et al [16]. These authors demonstrated that exposure to an APS concentration of 4 mg·m -3 for 7 days, 23.5 h·day -1 , caused a decreased body weight and an increased fresh lung weight.…”

Section: Discussionsupporting

confidence: 82%

Acute exposure to hair bleach causes airway hyperresponsiveness in a rabbit model

Mensing

Marek²,

Raulf‐Heimsoth³

et al. 1998

Eur Respir J

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Ammonium persulphate (APS) and hydrogen peroxide (H2O2) are used as oxidants in many industrial processes and are the main constituents of standard hair bleaching products. In a previous study, it was demonstrated that aerosols of APS induce alterations in airway responsiveness. The present study examined whether exposure for 4 h to a hair bleach composition (containing APS, potassium persulphate and H2O2) or H2O2 could induce airway hyperresponsiveness and/or an obstructive ventilation pattern in a rabbit model. Exposure to the aerosols altered neither baseline airway resistance, dynamic elastance, slope of inspiratory pressure generation nor arterial blood pressure and blood gas measurements. Similarly to APS, hair bleach aerosols containing > or =10.9 mg x m(-3) persulphate (ammonium and potassium salt) in air and > or =1.36 mg x m(-3) H2O2 in air caused airway hyperresponsiveness to acetylcholine after 4 h of exposure. Aerosolized H2O2 (> or =37 mg x m(-3) in air) did not influence airway responsiveness to acetylcholine. The results demonstrate that hair bleaching products containing persulphates dissolved in H2O2 cause airway hyperresponsiveness to acetylcholine in rabbits.

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Section: Discussionsupporting

confidence: 82%

Acute exposure to hair bleach causes airway hyperresponsiveness in a rabbit model

Mensing

Marek²,

Raulf‐Heimsoth³

et al. 1998

Eur Respir J

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“…This study suggests that ammonium persulfate may be less toxic via inhalation than indicated in the previously reported study conducted by Last et al (1982).…”

Section: Discussionsupporting

confidence: 60%

“…Although lung weights were increased in this study and compare qualitatively with effects observed by Last et al (1982), the effects occurred under different exposure conditions. In the Last et al study, persulfate was generated as a liquid aerosol, 23 h/day for 7 days, and lung weight evaluations were made following soon after exposure.…”

Section: Discussionmentioning

confidence: 42%

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13-Week Inhalation Toxicity Study (Including 6- And 13-Week Recovery Periods) With Ammonium Persulfate Dust in Albino Rats

Signorin

Ulrich²,

Butt³

et al. 2001

Inhalation Toxicology

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The subchronic inhalation toxicity of ammonium persulfate was characterized using Sprague-Dawley rats (20/sex/group) at respirable dust concentrations of 0, 5.0, 10.3, and 25 mg/m(3). Whole-body exposures were conducted 6 h/day, 5 days/wk for 13 wk. Gravimetric airborne test material samples were taken daily and particle size samples were taken weekly from each exposure chamber for analysis. Ten animals/sex/group were necropsied after 13 wk of exposure, and 5 animals/sex/group were held for 6- and 13-wk recovery periods. Animals were observed for clinical signs. Effects on body weight, food consumption, clinical chemistry and hematology, ophthalmologic parameters, organ weights, gross lesions, and histopathology were evaluated. There were no exposure-related deaths during the study. Rales and increased respiration rate were noted in both males and females in the 25 mg/m(3) group, and in a few animals in the 10.3 mg/m(3) group. The incidence of these clinical signs decreased to zero during the first few weeks of the recovery period. Body weights for both males and females in the 25 mg/m(3) group were significantly depressed during most of the exposure period compared to the control group. By the end of the recovery period, body weights for the exposed animals were similar to the control group values. Lung weights were elevated in the 25 mg/m(3) group after 13 wk of exposure, but were similar to controls at 6 wk postexposure. Irritation of the trachea and bronchi/bronchiole was noted microscopically after 13 wk of exposure to 25 mg/m(3). These lesions had recovered by 6 wk postexposure. Based on the results of this study, the no-observed-adverse-effect level (NOAEL) was 10.3 mg/m(3), while the no-observed-effect level (NOEL) for exposure of rats to a dust aerosol of ammonium persulfate was 5.0 mg/m(3).

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“…Exposure of rats to 4 mg/m 3 ammonium persulfate for 23.5 hours a day also increased glycoprotein secretion in rat tracheal explants. 20 Similarly, tracheal explants from hamsters exposed to 1.1 mg/m 3 sulfuric acid (mean size 0.12 µm) alone or in combination with 1.5 mg/m 3 carbon particles (mean size 0.3 µm) damaged the airway epithelium and increased the quantity of acid mucus. Scan-ning electron microscopy showed mucous strands forming a network-like structure.…”

Section: Particulatesmentioning

confidence: 99%

Atmospheric Pollutants and Cigarette Smoke

Abraham¹

1984

Semin Respir Crit Care Med

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Inhalation toxicology of ammonium persulfate, an oxidant aerosol, in rats

Cited by 15 publications

References 22 publications

Acute exposure to hair bleach causes airway hyperresponsiveness in a rabbit model

Acute exposure to hair bleach causes airway hyperresponsiveness in a rabbit model

13-Week Inhalation Toxicity Study (Including 6- And 13-Week Recovery Periods) With Ammonium Persulfate Dust in Albino Rats

Atmospheric Pollutants and Cigarette Smoke

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