2006
DOI: 10.1093/toxsci/kfl146
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Inhalational Exposure to Carbonyl Sulfide Produces Altered Brainstem Auditory and Somatosensory-Evoked Potentials in Fischer 344N Rats

Abstract: Carbonyl sulfide (COS), a chemical listed by the original Clean Air Act, was tested for neurotoxicity by a National Institute of Environmental Health Sciences/National Toxicology Program and U.S. Environmental Protection Agency collaborative investigation. Previous studies demonstrated that COS produced cortical and brainstem lesions and altered auditory neurophysiological responses to click stimuli. This paper reports the results of expanded neurophysiological examinations that were an integral part of the pr… Show more

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Cited by 18 publications
(12 citation statements)
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“…[25][26][27] After a brief assessment of the mice in their home cages (activity, rearing, eating, climbing, stereotypy, grooming, and abnormal movements), each animal was removed and held on the observer's hand for scoring ease of removal, handling reactivity, and general appearance. Each mouse was then placed in an exploratory white box (60 Â90 cm), where the observer analyzed central nervous system activity (arousal, rearing), autonomic effects (urination, defecation), muscle tone/equilibrium (gait, mobility, righting reflex, inverted screen), and sensorimotor reactivity (approach response, click response, touch response).…”
Section: Fobmentioning
confidence: 99%
“…[25][26][27] After a brief assessment of the mice in their home cages (activity, rearing, eating, climbing, stereotypy, grooming, and abnormal movements), each animal was removed and held on the observer's hand for scoring ease of removal, handling reactivity, and general appearance. Each mouse was then placed in an exploratory white box (60 Â90 cm), where the observer analyzed central nervous system activity (arousal, rearing), autonomic effects (urination, defecation), muscle tone/equilibrium (gait, mobility, righting reflex, inverted screen), and sensorimotor reactivity (approach response, click response, touch response).…”
Section: Fobmentioning
confidence: 99%
“…Furthermore, SEPs are also used in experimental toxicology studies in order to investigate the conduction velocity of different stages of afferent pathway and the postsynaptic response to the quantity of sensory input (Canu et al, 2003;Herr et al, 2007;Shapiro, 2002). Compared with the C group, all SEP components were prolonged in S group.…”
Section: Discussionmentioning
confidence: 99%
“…The components of SEP waves are characterized by the latency, reflecting the conduction velocity of different stages of afferent pathway and, the amplitude, corresponding to the postsynaptic response to the quantity of sensory input (Canu et al, 2003;Herr et al, 2007;Shapiro, 2002). These potentials have become an important diagnostic method when evaluating complications caused by neurotoxic agents (Lukács et al, 2007;Herr et al, 2007;Lebrun et al, 2000).…”
Section: Introductionmentioning
confidence: 99%
“…The typical approach to testing for statistically significant differences in latency and threshold data is by various forms of analysis of variance (ANOVA), depending on experiment design (this includes other studies published by these authors) (Lilienthal and Winneke, 1996;Rebert et al, 1991;Meerts et al, 2004;Herr et al, 2007). In the present study, the authors report performing ANOVA analyses, but then they chose to apply the benchmark method with critical effect size analysis for demonstrating a risk.…”
Section: Letter To the Editormentioning
confidence: 99%