Inhaled corticosteroids decrease vascularity of the bronchial mucosa in patients with asthma

Hoshino, Makoto; Takahashi, Miki; Takai, Yujiro; Sim, J.; Aoike, Nozomi

doi:10.1046/j.1365-2222.2001.01071.x

Cited by 83 publications

(72 citation statements)

References 28 publications

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“…This may be explained by the fact that they included patients with asthma who were being treated with inhaled corticosteroids in their analysis. In previous studies, ORSIDA et al [16] and the present authors [21] have shown that anti-inflammatory Values are presented as mean (range). M: male; F: female; FEV1: forced expiratory volume in one second; pred: predicted; Dmin: airway hyperresponsiveness as the minimum cumulative unit is equal to 1 min of 1.0 mg?mL -1 aerosol inhalation of methacholine.…”

Section: Discussionmentioning

confidence: 52%

Increased immunoreactivity of stromal cell-derived factor‐1 and angiogenesis in asthma

Hoshino¹,

Aoike²,

Takahashi³

et al. 2003

Eur Respir J

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Stromal cell-derived factor-1 (SDF-1) acts as a chemoattractant for leukocytes and can induce neovascularisation. To examine the role of SDF-1 in the development of angiogenesis, immunohistochemical studies were performed on bronchial biopsy specimens from asthmatic and control subjects.Bronchial biopsy specimens were obtained from 13 asthmatic and eight control subjects. The number of vessels and the percentage area they occupied were estimated after staining for type-IV collagen. In addition the number of SDF-1-positive cells was determined.There was a significant increase in the number of vessels and the percentage vascularity in the submucosa of asthmatic subjects compared with control subjects. Asthmatic subjects exhibited a greater number of SDF-1-positive cells in the airway mucosa than control subjects. The degree of vascularity was associated with the number of SDF-1-positive cells. Furthermore, the number of SDF-1-positive cells was inversely correlated with airway calibre and airway hyperresponsiveness. Colocalisation studies revealed that endothelial cells, macrophages and T-lymphocytes were the major sources of SDF-1.These findings suggest that increased vascularity of bronchial mucosa in asthmatic subjects is closely related to the expression of stromal cell-derived factor-1 positive cells, which may play a role in remodelling of airways via angiogenesis. Eur Respir J 2003; 21: 804-809.

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Section: Discussionmentioning

confidence: 52%

Increased immunoreactivity of stromal cell-derived factor‐1 and angiogenesis in asthma

Hoshino¹,

Aoike²,

Takahashi³

et al. 2003

Eur Respir J

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“…Angiogenesis in asthma may play multiple roles in disease progression, including the recruitment of inflammatory cells to the airways, the contribution to altered airway physiology, and the secretion of a variety of mediators that determine or regulate the inflammatory response (27,28,77). Interestingly, increased vascularization of the asthmatic lung appears to be the only component of airway remodeling that is fully reversible with treatment using glucocorticosteroids (78). Taken together, these data suggest that neovascularization in asthma contributes to the disease process and may serve as a therapeutic target.…”

Section: Discussionmentioning

confidence: 99%

Th1- and Th2-Dependent Endothelial Progenitor Cell Recruitment and Angiogenic Switch in Asthma

Asosingh

Swaidani

Aronica

et al. 2007

The Journal of Immunology

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Increased numbers of submucosal vessels are a consistent pathologic component of asthmatic airway remodeling. However, the relationship between new vessel formation and asthmatic inflammatory response is unknown. We hypothesized that angiogenesis is a primary event during the initiation of airway inflammation and is linked to the recruitment of bone marrow-derived endothelial progenitor cells (EPC). To test this hypothesis, circulating EPC and EPC-derived endothelial cell colony formation of individuals with asthma or allergic rhinitis and health controls was evaluated. Circulating EPC were increased in asthma, highly proliferative, and exhibited enhanced incorporation into endothelial cell tubes as compared with controls. In an acute allergen challenge murine asthma model, EPC mobilization occurred within hours of challenge and mobilized EPC were selectively recruited into the challenged lungs of sensitized animals, but not into other organs. EPC recruitment was Th1 and Th2 dependent and was temporally associated with an increased microvessel density that was noted within 48 h of allergen challenge, indicating an early switch to an angiogenic lung environment. A chronic allergen challenge model provided evidence that EPC recruitment to the lung persisted and was associated with increasing microvessel density over time. Thus, a Th1- and Th2-dependent angiogenic switch with EPC mobilization, recruitment, and increased lung vessel formation occurs early but becomes a sustained and cumulative component of the allergen-induced asthmatic response.

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“…A study carried out by SONT et al [49] showed that subjects treated with corticosteroids over a period of 2 yrs experienced a lower rate of mild exacerbations, an improved FEV1 and a reduction in the thickness of the subepithelial layer compared with the control group. In a double-blind study of 28 asthmatic subjects, HOSHINO et al [50] demonstrated that treatment with the inhaled steroid beclomethasone dipropionate significantly reduced the vessel number and vascularity in the airways of steroid treated patients. Further study showed that biopsy samples taken before and after treatment with an inhaled steroid revealed a decrease in inflammatory cells and a reduced amount of epithelial damage after 10 yrs, although bronchial hyperresponsiveness remained the same [51].…”

Section: Reversibility Of Remodelling?mentioning

confidence: 99%

The contribution of transforming growth factor-β and epidermal growth factor signalling to airway remodelling in chronic asthma

Boxall

Holgate²,

Davies³

2006

Eur Respir J

226

187

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Asthma is increasing in prevalence in the developing world, affecting ,10% of the world's population. It is characterised by chronic lung inflammation and airway remodelling associated with wheezing, shortness of breath, acute bronchial hyperresponsiveness to a variety of innocuous stimuli and a more rapid decline in lung function over time.Airway remodelling, involving proliferation and differentiation of mesenchymal cells, particularly myofibroblasts and smooth muscle cells, is generally refractory to corticosteroids and makes a major contribution to disease chronicity. Transforming growth factor-b is a potent profibrogenic factor whose expression is increased in the asthmatic airways and is a prime candidate for the initiation and persistence of airway remodelling in asthma.This review highlights the role of transforming growth factor-b in the asthmatic lung, incorporating biosynthesis, signalling pathways and functional outcome. In vivo, however, it is the balance between transforming growth factor-b and other growth factors, such as epidermal growth factor, which will determine the extent of fibrosis in the airways.A fuller comprehension of the actions of transforming growth factor-b, and its interaction with other signalling pathways, such as the epidermal growth factor receptor signalling cascade, may enable development of therapies that control airway remodelling where there is an unmet clinical need.

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Inhaled corticosteroids decrease vascularity of the bronchial mucosa in patients with asthma

Abstract: These findings suggest that inhaled corticosteroid treatment of asthma reduced airway wall vascularity during airway remodelling.

Cited by 83 publications

References 28 publications

Increased immunoreactivity of stromal cell-derived factor‐1 and angiogenesis in asthma

Increased immunoreactivity of stromal cell-derived factor‐1 and angiogenesis in asthma

Th1- and Th2-Dependent Endothelial Progenitor Cell Recruitment and Angiogenic Switch in Asthma

The contribution of transforming growth factor-β and epidermal growth factor signalling to airway remodelling in chronic asthma

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