Inhaled Hydrogen Gas Therapy for Prevention of Renal Ischemia/Reperfusion Injury in Rat Model

Akdeniz, Ekrem; Bostanci, Yakup; Özden, Ender; Meydan, Bilge Can; Yılmaz, Ali Faik; Sarıkaya, Şaban; Yakupoğlu, Yarkın Kamil

doi:10.5336/medsci.2012-32626

Cited by 1 publication

(1 citation statement)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this model, 30 rats were used, and 2% hydrogen gas was given to the study group during ischemia before and for one hour after ischemia. The investigators reported that hydrogen gas significantly reduced IR damage in the kidney in the early and late periods in the histopathological examination of nephrectomy material performed after six hours (early stage) and 14 days (late period) of ischemia [ 16 ]. The nephroprotective effect of remifentanil and dexmedetomidine was investigated in the IR model created in the kidney.…”

Section: Discussionmentioning

confidence: 99%

Nephroprotective Efficacy of Sugammadex in Ischemia-Reperfusion Injury: An Experimental Study in a Rat Model

Tercan¹,

İnal²,

Şeneldir³

et al. 2021

Cureus

View full text Add to dashboard Cite

Background: It is known that ischemia-reperfusion damage in the kidney is one of the most common causes of acute kidney failure. It is also known that reduced renal damage has a nephroprotective effect by reducing the release of inflammatory and vasoactive peptides that cause tissue damage. Therefore, we think that reperfusion caused by ischemia in kidney damage may be an important focus for clinical research.Methods: A total of 21 healthy 230-250 g female rats were used in our experimental study. During the experiment, animals were randomly divided into three groups, each containing seven rats. Group 1: The group that underwent left nephrectomy with a sham operation. Group 2: Left renal ischemia for 60 minutes, then left nephrectomy followed by 45 minutes of reperfusion. Group 3: Left renal ischemia for 60 minutes, then reperfusion for 45 minutes, followed by left nephrectomy. In this group, sugammadex was given intravenously at a dose of 100 mg/kg at the beginning of reperfusion. In the histomorphological examination, damage findings of tubules atrophy, dilation and cast formation, tubular epithelial brush border loss and vacuolization, presence of fibrosis as interstitial structural change, capillary vasodilatation/congestion and neutrophilic cell infiltrates in interstitial spaces, and morphological changes in glomeruli were evaluated.Results: When evaluated based on tubular brush border, there were no significant differences between Group 2 and Group 1 (P = 0.454), while the damage in Group 3 was less significant than Group 2 (P = 0.017). When evaluated in terms of tubular vacuolization, there was no significant difference between Group 2 and Group 1 (P = 0.902), while the damage in Group 3 was less significant than Group 2 (P = 0.017). Conclusion:We believe that 100 mg/kg sugammadex given at the beginning of reperfusion after one hour of ischemic condition on rats has a histochemically detectable nephroprotective effect.

show abstract

Section: Discussionmentioning

confidence: 99%