Inhaled Lavandula angustifolia essential oil inhibits consolidation of contextual- but not tone-fear conditioning in rats

Coelho, Laura Segismundo; Correa-Netto, Nelson Francisco; Masukawa, Márcia Yuriko; Lima, Ariadiny Caetano; Maluf, S. A.; Linardi, Alessandra; Santos-Junior, Jair Guilherme

doi:10.1016/j.jep.2017.12.038

Cited by 14 publications

(10 citation statements)

References 41 publications

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“…Our findings were consistent with previously studies, which were performed to reveal the variations in constituents of lavender EOs derived from growing location, different cultivars, climatic conditions, and other characteristics. The cell proliferation and growth inhibitory effects of the EOs may be due to the fact that rich constituent of terpenes and terpenoids such as linalool, linalyl acetate, cineole, -ocimene, lavandulol, terpinen-4-ol and camphor (Cavanagh and Wilkinson, 2002;Koulivand et al, 2013;Coelho et al, 2017;Shokri et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

“…It was determined that EO from the flowers of lavender obtained by stem distillation or hydrodistillation, contains more than 300 biologically active chemical compounds and components including linalyl acetate, linalool, lavandulyl acetate, lavandulol, -terpineol, -caryophyllene, cis--ocimene, camphor, and ketones, of which, linalyl acetate and linalool are identified as the major components of the lavender oil. EOs from lavender are characterized by the presence of terpenes and terpenoids, which are particularly responsible for its biological and pharmacological properties (Umezu et al, 2006;Dupuy et al, 2014;Prusinowska and Emigielski, 2014;Carrasco et al, 2016;Coelho et al, 2017). Additionally, the qualitative and quantitative composition of whole lavender oil can vary significantly depending on genotype, growing location, climatic conditions, and morphological characteristics (Cavanagh and Wilkinson, 2002;Emigielski et al, 2013;Lesage-Meessen et al, 2015;Fahim et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

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Original article Promising anticancer activity of lavender (Lavandulaangustifolia Mill.) essential oil through induction of both apoptosis and necrosis

Gezici¹

2018

Ann. Phytomed

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In the current study, potential anticancer and antiproliferative activity of EOs from lavender (Lavandula angustifolia Mill.) were determined against A549, H1299, C6 cancer cells and nontumorous HUVEC cells through induction of both apoptosis and necrosis. Furthermore, the differentiations of the cancer prevention activities of the EOs distilled from first and second year's harvest of the lavender growing under traditional system and plastic mulch were investigated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), trypan blue, neutral red uptake assays as well as lactate dehydrogenase (LDH) assay. The EOs exhibited remarkable anticancer and antiproliferative activity against all treated cancer cells, in a dose and time dependent manner. They exerted significantly decreases the cell growth in cancer cells, and also observed higher toxicity towards C6 glioma cells than the A549 and H1299 lung cells. In case of growing conditions of the EOs, higher anticancer and antiproliferative activity were observed under growing plastic mulch as compared to that of traditional system. Furthermore, first year's harvest of the lavender growing under plastic mulch seem to be possessed stronger cytotoxic effect than that of the second year's harvest. Besides, the lysosomal and LDH activity of the EOs were found to be highly in correlation with anticancer activity, and seem to be decreased obviously depending the year. It may be concluded that data obtained from the presented research demonstrates lavender EOs could have possible usage for cancer treatment as an alternative anticancer agent.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Original article Promising anticancer activity of lavender (Lavandulaangustifolia Mill.) essential oil through induction of both apoptosis and necrosis

Gezici¹

2018

Ann. Phytomed

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“…No trabalho de Coelho et al 32 procurou-se investigar os efeitos da inalação do óleo essencial da Lavandula angustifolia sobre a memória aversiva, assim como a sua influência na expressão do c-Fos, um gene envolvido em importantes eventos celulares como a hipóxia. Com isso, ratos Wistar machos adultos foram submetidos a um protocolo de condicionamento ao medo, e logo em seguida estes ratos permaneceram por durante 4 horas expostos a água vaporizada ou óleo essencial em soluções de 1%, 2,5% e 5%.…”

Section: Resultados E Discussão O Aspectos Botânicos Da Plantaunclassified

Lavandula angustifolia Miller e sua utilização na Odontologia: uma breve revisão

Souza¹,

Cruz²,

Gomes³

et al. 2019

Arch Health Invest

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O uso de medicamentos fitoterápicos vem crescendo mundialmente entre os programas preventivos e curativos, e tem estimulado a avaliação dos extratos de plantas para o uso na odontologia como controle do biofilme dental e outras desordens bucais. As plantas do gênero Lavandula, pertencem à família Lamiaceae, e têm sido utilizadas através dos anos para uma variedade de propósitos cosméticos e terapêuticos. Sua utilização na odontologia é, na grande maioria dos estudos, devido ao seu potencial ansiolítico. Entretanto, a Lavandula angustifólia demonstra outros potencias farmacológicos, como sua atividade antimicrobiana, antifúngica, anti-inflamatória e antinociceptiva. O presente estudo teve como objetivo integrar os conhecimentos já existentes sobre os aspectos das propriedades farmacológicas da Lavandula angustifolia Miller e sua aplicação na Odontologia. Trata-se de uma revisão bibliográfica no qual foi realizada uma seleção de artigos científicos a partir das bases de dados: Lilacs, MEDLINE, BVS e Scielo, além de monografias que atenderam aos requisitos do tema abordado, no período 2008 a 2018 com exceção de artigos clássicos que se apresentaram imprescindíveis ao presente estudo. Obteve-se um total de 1.532 artigos. Foram selecionados 38 artigos como amostra, que apresentaram a temática elencada para a pesquisa e que foram divididos por sessões: aspectos botânicos da planta; aspectos bioquímicos da planta; potencial antimicrobano; potencial anti-inflamatório; potencial ansiolítico e; potencial antinociceptivo. Pode-se concluir que a Lavandula angustifóliaMiller apresenta-se como uma boa alternativa para utilização na odontologia. Entretanto, a falta de trabalhos que abordem sua utilidade na odontologia revela a necessidade de se intensificar as pesquisas sobre o assunto.Descritores: Plantas Medicinais; Odontologia; Lavandula.ReferênciasFrancisco KSF. Fitoterapia: uma opção para o tratamento odontológico. Rev Saúde. 2010;4(1):18-24.Silveira SM, Cunha Júnior A, Scheuermann GN, Secchi FL, Silvani V, Marisete K et al . Composição química e atividade antibacteriana dos óleos essenciais de Cymbopogon winterianus (citronela), Eucalyptus paniculata (eucalipto) e Lavandula angustifolia (lavanda). Rev Inst Adolfo Lutz. 2012;71(3):462-70.Koulivand PH, Ghadiri MK, Gorji A. Lavender and the nervous system. Evid Based Complement Alternat Med. 2013;2013:681304.Verma RS, Rahman LU, Chanotiya CS, Verma RK, Chauhan A, Yadav A et al. Essential oil composition of Lavandula angustifolia Mill. cultivated in the mid hills of Uttarakhand, India. J Serb Chem Soc. 2010;75(3):343-48.Biasi LA, Deschamps C. Plantas Aromáticas: do cultivo à produção de óleo essencial. Curitiba: Layer;2009.Lorenzi, H, Matos EJA. Plantas medicinais do Brasil: nativas e exóticas. 2. ed. Nova Odessa: Instituto Plantarum de Estudos da Flora;2008.Índice Terapêutico Fitoterápico (ITF). Petrópolis: Editora de Publicações Biomédicas;2008.Chioca LR. Avaliação do mecanismo de ação do efeito tipo ansiolítico da inalação do óleo essencial de lavanda em camundongos [tese]. Curitiba: Universidade Federal do Paraná;2013.Zabirunnisa M, Gadagi JS, Gadde P, Myla N, Koneru J, Thatimatla C. Dental patient anxiety: Possible deal with Lavender fragrance. J Res Pharm Pract. 2014;3(3):100-3.Platt ES. Lavender: How to grow and use the fragrant herb. 2. ed. Mechanicsburg PA: Stackpole Books;2009.Hajhashemi V, Ghannadi A, Sharif B. Anti-inflammatory and analgesic properties of the leaf extracts and essential oil of Lavandula angustifolia Mill. J Ethnopharmacol. 2003;89(1):67-71.Machado MP, Ciotta MN, Deschamps C, Zanette F, Côcco LC, Biasi LA. In vitro propagation and chemical characterization of the essential oil of Lavandula angustifolia cultivated in Southern Brazil. Cienc Rural 2013;43:283-89.Porto C da, Decorti D, Kikic I. Flavour compounds of Lavandula angustifolia L. to use in food manufacturing: Comparison of three different extraction methods. Food Chem. 2009;112(4):1072-78.Duke JA. Handbook of Medicinal Herbs. Flórida: CRC;2000.Mantovani ALL, Vieira GPG, Cunha WR, Groppo M, Santos RA, Rodrigues V et al . Chemical composition, antischistosomal and cytotoxic effects of the essential oil of Lavandula angustifolia grown in Southeastern Brazil. Rev. bras. farmacogn. 2013;23(6):877-84.Jianu C, Pop G, Gruia AT, Horhat FG. Chemical Composition and Antimicrobial Activity of Essential Oils of Lavender (Lavandula angustifolia) and Lavandin (Lavandula x intermedia) Grown in Western Romania. Int J Agric Biol. 2013;15(4):772-76.Lam M, Jou Pc, Lattif Aa, Lee Y, Malbasa Cl, Mukherjee Pk et al. Photodynamic therapy with Pc 4 induces apoptosis of Candida albicans. Photochem Photobiol. 2011;87(4):904-9.Pereira CA, Romeiro RL, Costa AC, Machado AK, Junqueira JC, Jorge AO. Susceptibility of Candida albicans, staphylococcus aureus, and streptococcus mutans biofilms to photodynamic inactivation: an in vitro study. Lasers Med Sci. 2011;26(3):341-48.Neville BW, Damm DD, Allen CM, Bouquot JE. Patologia Oral e Maxilofacial. 3. ed. Rio De Janeiro: Elsevier;2009.de Rapper S, Kamatou G, Viljoen A, van Vuuren S. The in vitro antimicrobial activity of lavandula angustifolia essential oil in combination with other aroma-therapeutic oils. Evid Based Complement Alternat Med. 2013;2013:852049.Uniyal V, Bhatt RP, Saxena S, Talwar A. Antifungal activity of essential oils and their volatile constituents against respiratory tract pathogens causing Aspergilloma and Aspergillosis by gaseous contact. J Appl Nat Sci. 2012;4(1):65-70.Ribeiro BP, Pereira WS, Sousa AIP, Guerra RNM, Nascimento FRF. Alteração no perfil bioquímico induzido por reação inflamatória granulomatosa em camundondos. Rev Ciênc Saúde. 2010;12(1):73-9.Rubin E, Gorstein F, Rubin R, Schwarting R, Strayer D. Patologia. Bases clínicopatológicas da Medicina. 4. ed. Rio de Janeiro: Guanabara Koogan;2006.Silva GL. Avaliação da atividade antioxidante, antiinflamatória e antinociceptiva do óleo essencial de lavanda (Lavandula angustifolia Mill) [dissertação]. Dissertação (Mestrado). Porto Alegre: Universidade Católica do Rio Grande do Sul;2009.Cryan, JF, Sweeney FF. The age of anxiety: role of animal models of anxiolytic action in drug discovery. Br J Pharmacol. 2011;164(4):1129-61.Barik J, Marti F, Morel C, Fernandez SP, Lanteri C, Godeheu G et al. Chronic stress triggers social aversion via glucocorticoid receptor in dopaminoceptive neurons. Science. 2013;339(6117):332-35.Martin EI, Ressler KJ, Binder E, Nemeroff CB. The neurobiology of anxiety disorders: brain imaging, genetics, and psychoneuroendocrinology. Psychiatr Clin North Am. 2009;32(3):549-75.Oler JA, Fox AS, Shelton SE, Rogers J, Dyer TD, Davidson RJ et al. Amygdalar and hippocampal substrates of anxious temperament differ in their heritability. Nature. 2010;466(7308):864-68.Loggia ML, Schweinhardt P, Villemure MC, Bushnell Mc. Effects of psychological state on pain perception in the dental environment. J Can Dent Assoc. 2008;74(7):651-56.Carvalho RWF, Falcão PGCB, Campos GJL, Bastos AS, Pereira JC, Pereira MAS et al. Ansiedade frente ao tratamento odontológico: prevalência e fatores predictores em brasileiros. Ciênc Saúde Colet. 2012;17(7):1915-22.Siviero M, Nhani VT, Prado EFGB. Análise da ansiedade como fator preditor de dor aguda em pacientes submetidos à exodontias ambulatoriais. Rev Odontol UNESP. 2008;37(4):329-36Coelho LS, Correa-Netto NF, Masukawa MY, Lima AC, Maluf S, Linardi A et al. Inhaled Lavandula angustifolia essential oil inhibits consolidation of contextual-but not tone-fear conditioning in rats. J Ethnopharmacol. 2018;215:34-41.Oliveira RRB, Góis RMO, Siqueira RS, Almeida JRGS, Lima JT, Nunes XP et al . Antinociceptive effect of the ethanolic extract of Amburana cearensis (Allemão) A.C. Sm., Fabaceae, in rodents. Rev bras farmacogn. 2009;19(3):672-76.Millan MJ. Descending control of pain. Prog Neurobiol. 2002;66(6):355-474.Julius D, Basbaum AI. Molecular mechanisms of nociception. Nature. 2001;413(6852):203-10.Centers for Disease Control and Prevention. Unintentional drug poisoning in the United States. CDC: Atlanta, 2010. Disponível em: https://www.cdc.gov/homeandrecreationalsafety/pdf/poison-issue-brief.pdf.Donatello NN. Ativação de receptores opioides periféricos e espinais pela inalação do óleo essencial de lavandula augustifolia reduz hiperalgesia mecânica em modelos animais de neuropatia e inflamação crônica [dissertação]. Palhoça: Universidade do Sul de Santa Catarina, Pós-graduação em Ciências da Saúde;2017.Maior FNS. Atividade ansiolítica e antinociceptiva do óxido de linalol em modelos animais [tese]. João Pessoa: Universidade Federal da Paraíba;2011.

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“…The inhalation of EOs can induce anxiolytic effects through the central nervous system or stimulation of the olfactory system and secondary activation of brain regions [184]. Rats that inhaled L. angustifolia EO at 2.5% and 5% (but not 1%) showed inhibited consolidation of contextual-but not tone-fear conditioning [124]. A study performed in mice conclude that serotonergic neurotransmission plays a certain role in the anxiolytic properties of L. officinalis EO [185].…”

Section: Anxiolytic Activitymentioning

confidence: 99%

Plants of the Genus Lavandula: From Farm to Pharmacy

Salehi

Mnayer

Özçelik

et al. 2018

Natural Product Communications

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The Lavandula genus, belonging to the Lamiaceae, includes 39 species, with nearly 400 registered cultivars. Lavandula are worldwide plants that occur over the Mediterranean, Europe, North Africa, southwest Asia to southeast India. Lavandula plants have been used since ancient time to flavor and preserved food, to treat diseases including wound healing, sedative, antispasmodic, microbial and viral infections. Numerous researches have described the chemical composition and the primary components of lavender oils are the monoterpenoids (linalool, linalyl acetate, 1,8-cineole, β-ocimene, terpinen-4-ol, and camphor), sesquiterpenoids (β-caryophyllene and nerolidol) and other terpenoid compounds (e.g., perillyl alcohol). The high concentrations of linalyl acetate make them attractive in perfumery, flavoring, cosmetics and soap industries. Currently, data on the antimicrobial activity of lavender plants have been scientifically confirmed. Indeed, lavender essential oils possess wide spectra of biological activities such as antispasmodic, carminative, analgesic, sedative, hypotensive, antiseptic, antimicrobial, antifungal, antidiuretic and general tonic action. In addition, clinical studies support their uses as treatment of health conditions. However, further clinical studies are necessary to define the magnitude of the efficacy, mechanisms of action, optimal doses, long-term safety, and, potential side effects of lavender plants.

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Inhaled Lavandula angustifolia essential oil inhibits consolidation of contextual- but not tone-fear conditioning in rats

Cited by 14 publications

References 41 publications

Original article Promising anticancer activity of lavender (Lavandulaangustifolia Mill.) essential oil through induction of both apoptosis and necrosis

Original article Promising anticancer activity of lavender (Lavandulaangustifolia Mill.) essential oil through induction of both apoptosis and necrosis

Lavandula angustifolia Miller e sua utilização na Odontologia: uma breve revisão

Plants of the Genus Lavandula: From Farm to Pharmacy

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