Inhaled linalool-induced sedation in mice

Sedative effect of central administration ofCoriandrum sativumessential oil and its major component linalool in neonatal chicks

“…or oral administration of aqueous or alcoholic coriander extracts and CEO have anxiolytic effect and may have potential sedative effect in mice exposed to elevated plus-maze or dark/light arena (Emamghoreishi et al 2005;Emamghoreishi & Heidari-Hamedani 2006;Pathan et al 2011;Ravindran et al 2014). Interaction among the various substances of an essential oil can modify the pharmacodynamic and pharmacokinetic properties of each one; nevertheless, studying the isolated components is helpful for a comprehensive understanding of the basis of essential oil physiological and psychopharmacological effects (Linck et al 2009). In the present study, according to GC-FIS and GC-MS analyses of CEO, we identified that the major component was the monoterpene linalool (81.7%), addition to various constituents in minor quantity as g-terpinene, a-pinene and camphor (3-6%), among others.…”

“…These results suggest that linalool had a dose-dependent sedative effect in neonatal chicks as observed for CEO (8.6 and 86 mg) and diazepam (17.5 mg). It has been reported that i.p administration or inhalation of linalool had a sedative effect in rodents and humans (Kuroda et al 2005;Linck et al 2009), however, until now, there are no reports with similar behavioural effects in avian species.…”

“…Cline et al (2008) reported that linalool may modulate motor movements and locomotion but not via g-aminobutyric acid type A (GABA A ) receptor. On the other hand, in vitro assays demonstrated that linalool acts as a competitive antagonist of ionotropic receptors of the type N-methyl-D-aspartate (NMDA) and inhibits glutamate release (Elisabetsky et al 1999), compatible with and relevant to the sedative effects observed, whether inhaled or otherwise administered (Linck et al 2009). Additional studies should be performed to determine the site of central action of CEO and linalool, and understand the molecular mechanisms involved for future clinical applications.…”

Biosynthesis and Therapeutic Properties ofLavandulaEssential Oil Constituents

“…Using such models, researchers can identify the action of specific lavender terpenoids in vivo. For instance, Linck et al [41] found that inhalation of linalool by mice resulted in sedative behavior, increased pentobarbital-induced sleeping time, decreased spontaneous activity, and reduced body temperature without a corresponding reduction in motor coordination. In addition, mice that inhaled a combination of linalool and linalyl acetate (another prominent component of lavender oil) exhibited an exposuredependent decrease in motility [42].…”

Análise de terpenóides de espécies de Croton sect. Lamprocroton (Mull. Arg.) Pax (Euphorbiaceae)

“…O linalol (11), bastante utilizado na indústria cosmética e de perfumes como fixador de fragrâncias possui atividades larvicida (Sylvestre et al, 2006), anti-leischmania (Rosa et al, 2003), anticonvulsiva (Elizabetski et al, 1995), sedativa (Elizabetski et al, 1995;Linck et al, 2009) e antinociceptiva (Blank et al, 2007). Em C. palanostigma representa 25,4% do óleo volátil foliar (Socorro et al, 2007) e em C. oligandrum 53,3% do óleo foliar (Agnaniet et al, 2006).…”