Sedative effect of central administration ofCoriandrum sativumessential oil and its major component linalool in neonatal chicks

Abstract

Context Coriandrum sativum L. (Apiaceae) (coriander) is an herb grown throughout the world as a culinary, medicinal or essential crop. In traditional medicine, it is used for the relief of anxiety and insomnia. Systemic hydro-alcoholic and aqueous extract from aerial parts and seeds had anxiolytic and sedative action in rodents, but little is known about its central effect in chicks. Objective To study the effects of intracerebroventricular administration of essential oil from coriander seeds and its major component linalool on locomotor activity and emotionality of neonatal chicks. Materials and methods The chemical composition of coriander essential oil was determined by a gas-chromatographic analysis (480% linalool). Behavioural effects of central administration of coriander oil and linalool (both at doses of 0.86, 8.6 and 86 mg/chick) versus saline and a sedative diazepam dose (17.5 mg/chick, standard drug) in an open field test for 10 min were observed. Results Doses of 8.6 and 86 mg from coriander oil and linalool significantly decreased (p50.05) squares crossed number, attempted escapes, defecation number and distress calls, and significantly increased (p50.05) the sleeping posture on an open field compared with saline and were similar to the diazepam group. Discussion and conclusion The results indicate that intracerebroventricular injection of essential oil from Coriandrum sativum seeds induced a sedative effect at 8.6 and 86 mg doses. This effect may be due to monoterpene linalool, which also induced a similar sedative effect, and, therefore, could be considered as a potential therapeutic agent similar to diazepam. ARTICLE HISTORY

Characterization of volatile organic compound emissions from self-bonded boards resulting from a coriander biorefinery

“…While α-pinene, β-pinene, δ-3-carene and limonene are widespread among wood species, the emission of linalool from construction materials has never been reported. Studies have illustrated the anxiolytic, memory-enhancing and neuroprotective effect of coriander essential oil upon inhalation and have attributed this to the presence of linalool (Cioanca et al, 2013;Emamghoreishi et al, 2005;Gastón et al, 2016). Further, numerous reports have described antibacterial and antifungal activity against a wide range of micro-organisms (Elgayyar et al, 2001), while Silva et al (2011) have stressed the significance of the S-(+)-enantiomer of linalool, which predominance was confirmed in this study, for the inhibitory activity against Gram negative bacteria including important food pathogens.…”

Anesthetic Efficiency of Three Medicinal Plant Oils for Aquatic Species: Coriander Coriandrum sativum, Linaloe Tree Bursera delpechiana, and Lavender Lavandula hybrida

“…Similarly, it has been previously reported that EO from coriander seeds induce a sedative effect in chickens (Gastón et al. ).…”

Traditional Chinese Medicine: Role in Reducing β-Amyloid, Apoptosis, Autophagy, Neuroinflammation, Oxidative Stress, and Mitochondrial Dysfunction of Alzheimer’s Disease

“…LI is the main volatile monoterpene compound found in several aromatic plants, such as Lavandula angustifolia Mill., Rosmarinus officinalis L. and Coriandrum sativum L. (Kuroda et al, 2005;Batista et al, 2010;Gastón et al, 2016). In a previous study, LI significantly improved the cognitive performance and alleviated Ab 1-40 -induced cell injury by increasing the levels of oxidative stress indicators such as SOD, GPX, and AChE.…”