Inhaled Sevoflurane for Long-Term Sedation

Abstract

Lead author: Malcie Mesnil Three part clinical question: Patients: Adult (18-80 years) patients weighing between 50-120 kg requiring more than 24 hours sedation. Intervention: Sedation with sevoflurane, propofol, or midazolam. Outcome: The primary endpoints were: wake-up times, extubation delay from termination of sedation administration. The secondary endpoints were: proportion of time within Ramsey Sedation Score 3-4, IV morphine consumption at 24 hours post extubation, hallucination episodes after the end of sedation, renal and hepatic consequences, and plasma fluoride concentration. The study design: Non-blinded, randomised controlled trial.