Inhaled Thiamphenicol and Acetilcysteine in Children with Acute Bacterial Rhinopharyngitis

Varricchio, Attilio; Capasso, Maria; Gioacchino, Mario Di; Ciprandi, Giorgio

doi:10.1177/039463200802100316

Cited by 26 publications

(18 citation statements)

References 11 publications

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“…Consistently, salsobromo-iodine thermal water reduced postnasal driprelated cough in children suffering from acute upper airway infection [116]. Antibiotics, such as tobramycin and thiamphenicol, were intranasally administered using a nasal micronized douche in children with acute rhinopharyngitis: both treatments significantly reduced the symptom severity [117,118]. An original therapeutic strategy was adopted in children with perennial allergic rhinitis, i.e.…”

Section: Therapeutic Strategies For Ua Diseases Based On Local and Rementioning

confidence: 99%

Inflammation, infection, and allergy of upper airways: new insights from national and real-world studies

Varricchio¹,

Mantia

Brunese³

et al. 2020

Ital J Pediatr

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The upper airways (UA) should be considered as a functional unit. Current functional anatomy divides URT in three, mutually dependent, "junction boxes": i) the ostio-meatal complex (OMC), ii) the spheno-ethmoidal recess (SER), and iii) the rhinopharynx (RP). Correct ventilation and effective mucociliary clearance of these sites significantly affect the healthy physiology of the entire respiratory system. The OMC, SER, and RP obstruction is the first pathogenic step in the inflammatory/infectious cascade of UA disorders. The inflammation of the respiratory mucosa is the main pathogenic factor for airway obstruction. Moreover, bacterial biofilm (a strategy modality of bacterial survival) is an important local cause of systemic antibiotic ineffectiveness, recurrent infections, and antibiotic resistance. Health microbiota guarantees UA wellness; on the contrary, dysbiosis promotes and worsens UA infections. Allergy, namely type 2 inflammation, is a common cause of UA obstruction such as promoting in turn infections. Fiberoptic endoscopy is a mandatory diagnostic tool in clinical practice. Nasal cytology, mainly concerning flow cytometry, allows defining rhinitis phenotypes so allowing a precision medicine approach. Several conventional therapeutic approaches are available, but efficacy and safety should be ever properly considered before the prescription. Also, complementary medicine plays a fruitful role in the management of UA diseases. National and real-world studies are reported and discussed as they may be useful in daily clinical practice.

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Section: Therapeutic Strategies For Ua Diseases Based On Local and Rementioning

confidence: 99%

Inflammation, infection, and allergy of upper airways: new insights from national and real-world studies

Varricchio¹,

Mantia

Brunese³

et al. 2020

Ital J Pediatr

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“…By analogy, it is possible to speculate that tissues taken from DPCs, from exfoliated deciduous teeth (EDCs) and from PDLCs contain a population of multi potential formative cells. International research is still working on the creation of clonogenic, highly proliferating cell lines deriving from pulp tissue from adult (DPSCs) deciduous teeth (SHEDs) or from periodontal ligament (PDLSCs) through enzymatic digestion and culture in the field of selective single-layered cell lines (18)(19)(20)(21)(22)(23).…”

mentioning

confidence: 99%

In Vitro Stem Cell Cultures from Human Dental Pulp and Periodontal Ligament: New Prospects in Dentistry

Ballini

Frenza

Cantore

et al. 2007

Int J Immunopathol Pharmacol

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In spite of the vast knowledge of tooth development and of the various kinds of specialized bone/ tooth-associated cells, the characteristics and properties oftheir precursor cell populations present in the postnatal organism are little known, as is their possible therapeutic use. Taken together dental pulp stem cells (DPSCs) and periodontal ligament stem cells (PDLSCs) possess stem-cell-like qualities, including self-renewal capability and multi-lineage differentiation. Regenerative medicine is based on stem cells, signals and scaffolds. Transplantation of those cells, which can be obtained from an easily accessible tissue resource and expanded in vitro, holds promise as a therapeutic approach for reconstruction of tissues and bone in vivo.

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“…The inhibition of MCP-1 is very important since this chemokine clearly promotes inflammation and is a member of the pro-inflammatory cytokines, whereas other cytokines suppress the activity of pro-inflammatory cytokines and are called anti-inflammatory cytokines [25][26][27][28][29] . Pro-inflammatory cytokines are a cascade of gene products usually not produced in healthy subjects.…”

Section: Discussionmentioning

confidence: 99%

Inhibitory Effect of Quercetin on Tryptase and MCP-1 Chemokine Release, and Histidine Decarboxylase mRNA Transcription by Human Mast Cell-1 Cell Line

Castellani

Kempuraj

Frydas

et al. 2006

Neuroimmunomodulation

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Mast cells are important in reactions of allergic disease and are also involved in a variety of neuroinflammatory diseases. Mast cells can be immunologically activated by IgE through their Fc receptors, as well as by neuropeptides and cytokines to secrete mediators. Here we used a human mast cell-1 (HMC-1) cell line cultured and treated with a physiological activator, anti-IgE, and a nonphysiological activator, calcium ionophore A23187, for tryptase and MCP-1 generation and transcription of histidine decarboxylase. We used quercetin, a potent antioxidant, cytoprotective and anti-inflammatory compound capable of inhibiting histamine and some cytokines released from several cell types, as an inhibitor of immunological and nonimmunological stimulus for mast cells. In this study quercetin inhibits, in a dose-response manner, tryptase and MCP-1. Moreover, using RT-PCR quercetin inhibited the transcription of histidine decarboxylase, the rate-limiting enzyme responsible for the generation of histamine from histidine, and MCP-1. Our data suggest that quercetin is an important and good candidate for reducing the release of pro-inflammatory mast cell mediators activated by physiological and nonphysiological stimulators.

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Inhaled Thiamphenicol and Acetilcysteine in Children with Acute Bacterial Rhinopharyngitis

Cited by 26 publications

References 11 publications

Inflammation, infection, and allergy of upper airways: new insights from national and real-world studies

Inflammation, infection, and allergy of upper airways: new insights from national and real-world studies

In Vitro Stem Cell Cultures from Human Dental Pulp and Periodontal Ligament: New Prospects in Dentistry

Inhibitory Effect of Quercetin on Tryptase and MCP-1 Chemokine Release, and Histidine Decarboxylase mRNA Transcription by Human Mast Cell-1 Cell Line

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