Inheritance of rupture of the cranial cruciate ligament in Newfoundlands

Wilke, Vicki L.; Conzemius, Michael G.; Kinghorn, Brian; Macrossan, Paula; Cai, Weiguo; Rothschild, Max F.

doi:10.2460/javma.228.1.61

Cited by 77 publications

(72 citation statements)

References 13 publications

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“…a common theme of many publications has been that CCL disease is becoming a condition of young, large breed dogs (BeNNett et al, 1988;JOhNSON and JOhNSON, 1993;DUVaL et al, 1999). Smaller breed dogs may rupture their cranial cruciate ligament (CCL) later in life than larger breed dogs because of slower CCL degeneration (WILke et al, 2006). Similar age and breed differences were noticed in our population of dogs.…”

Section: Resultssupporting

confidence: 74%

Breed, gender, age and reproductive status in relation to the predisposition for cranial cruciate ligament rupture in 117 dogs treated by a single surgeon (2010 - 2015) - a short communication

et al. 2017

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rupture of the cranial cruciate ligament (CCL) remains the most common canine orthopaedic problem seen in clinical practice. the present paper describes a population of 117 dogs with CCL rupture diagnosed by clinical examination followed by mini-arthrotomy. the dogs were treated from January 2010 to February 2015 at the Clinic for Surgery, Orthopaedics and Ophthalmology, Faculty of Veterinary Medicine, University of Zagreb, Croatia, by the same surgeon. The age, breed, gender and reproductive profile were analysed in relation to CCL rupture occurrence during the study and were discussed in relationship to previous published reports. Of the 117 dogs, 29.0% were mixed breed dogs and 13.7% Labrador retrievers as the most common. Males and females were equally affected. Bilateral rupture occurred in 5.85% cases, mostly in mixed breed females. Medial meniscal tear was observed in 22.2% of cases with mini-arthrotomy and probing. the average age of the small breed dogs was 8.3 years, and of the large breed dogs 4.2 years. Dogs aged 5 years and older had 2.5 times the likelihood of suffering from CCL rupture compared with dogs aged under 5 years (P<0.01).

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Section: Resultssupporting

confidence: 74%

Breed, gender, age and reproductive status in relation to the predisposition for cranial cruciate ligament rupture in 117 dogs treated by a single surgeon (2010 - 2015) - a short communication

et al. 2017

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Section: Discussionmentioning

confidence: 76%

“…1 However, in the present study, several chromosomal regions were significantly associated with CCLR status. This may reflect false identification of certain regions, or given the heritability estimate of 0.27 for this trait, 1 it is possible that expression of modifying genes may explain trait variability. Validation of the MSATs that were apparently significantly associated with the CCLR trait in Newfoundlands is necessary to determine the true association of the identified markers and identify chromosomal regions for further investigation.…”

Section: Discussionmentioning

confidence: 76%

“…1 Results of the present MSAT-based genome-wide association study in a population of Newfoundlands suggest that several chromosomal regions are associated with CCLR status. Fine mapping of these chromosomal regions should further narrow the list of potential CCLR candidate genes and allow for eventual identification of predisposed genotypes.…”

Section: Discussionmentioning

confidence: 95%

“…In a study 1 of Newfoundland dogs that were evaluated at a veterinary teaching institution in a 6-year period, 36 of 163 (22.1%) had CCLR. The economic impact of medical and surgical treatment for CCLR in dogs in 2003 was estimated at > $1.3 billion.…”

mentioning

confidence: 99%

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Identification of chromosomal regions associated with cranial cruciate ligament rupture in a population of Newfoundlands

Wilke

Zhang

Evans

et al. 2009

ajvr

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In the population of Newfoundlands, 4 MSATs that were located on 4 chromosomes were significantly associated with the CCLR trait. Three of those markers were validated in part via genotyping additional closely located markers. The MSATs that were associated with the CCLR trait were identified in all regions (except for those on chromosome 24). Newfoundlands with CCLR could be used to study the disease process associated with anterior cruciate ligament injuries that occur in young female human athletes.

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Disorders of the Pelvic Limb: Diagnosis and Treatment

Lotsikas¹,

Canapp²,

Dyce³

et al. 2013

Canine Sports Medicine and Rehabilitation

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Inheritance of rupture of the cranial cruciate ligament in Newfoundlands

Abstract: Identification of a genetic basis for RCCL in Newfoundlands provided evidence that investigators can now focus on developing methods to identify carriers to reduce the prevalence of RCCL.

Cited by 77 publications

References 13 publications

Breed, gender, age and reproductive status in relation to the predisposition for cranial cruciate ligament rupture in 117 dogs treated by a single surgeon (2010 - 2015) - a short communication

Breed, gender, age and reproductive status in relation to the predisposition for cranial cruciate ligament rupture in 117 dogs treated by a single surgeon (2010 - 2015) - a short communication

Identification of chromosomal regions associated with cranial cruciate ligament rupture in a population of Newfoundlands

Disorders of the Pelvic Limb: Diagnosis and Treatment

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