Inhibin, Activin, and Follistatin in Ovarian Physiology

Welt, Corrine K.; Schneyer, Alan L.

doi:10.1016/b978-0-12-813209-8.00006-6

Cited by 4 publications

(3 citation statements)

References 102 publications

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“…In these mutant mice, initial gonadal development was normal but their ovaries presented nodules of seminiferous-like tubules with Sertoli-like cells at 6–8 weeks [ 48 ]. Follistatin (FST) is a glycoprotein that cooperates with inhibins in neutralizing activins and pituitary FSH repression [ 47 , 49 , 50 ]. Granulosa cell-specific deletion of Fst in mice also led to reduced fertility with adult ovaries showing some seminiferous-like testis cords [ 51 ].…”

Section: Genes and Pathways Involved In The Maintenance Of The Female Cell Fatementioning

confidence: 99%

“…However, this does not seem to be the case, as the ovaries of transgenic mice overexpressing FSH showed no sign of transdifferentiation [ 52 ]. FST and inhibins regulate TGF-β/Activin signaling during foliculogenesis [ 49 , 50 ]. Interestingly, the activation of TGF-β receptor type-1 (TGFBR1) in Sertoli cells led to Inhibin A, FOXL2, and WNT signaling upregulation [ 53 ], thus exhibiting an evident granulosa-cell type gene expression pattern.…”

Section: Genes and Pathways Involved In The Maintenance Of The Female Cell Fatementioning

confidence: 99%

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Sex Maintenance in Mammals

Jiménez

Burgos

Barrionuevo

2021

Genes

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The crucial event in mammalian sexual differentiation occurs at the embryonic stage of sex determination, when the bipotential gonads differentiate as either testes or ovaries, according to the sex chromosome constitution of the embryo, XY or XX, respectively. Once differentiated, testes produce sexual hormones that induce the subsequent differentiation of the male reproductive tract. On the other hand, the lack of masculinizing hormones in XX embryos permits the formation of the female reproductive tract. It was long assumed that once the gonad is differentiated, this developmental decision is irreversible. However, several findings in the last decade have shown that this is not the case and that a continuous sex maintenance is needed. Deletion of Foxl2 in the adult ovary lead to ovary-to-testis transdifferentiation and deletion of either Dmrt1 or Sox9/Sox8 in the adult testis induces the opposite process. In both cases, mutant gonads were genetically reprogrammed, showing that both the male program in ovaries and the female program in testes must be actively repressed throughout the individual’s life. In addition to these transcription factors, other genes and molecular pathways have also been shown to be involved in this antagonism. The aim of this review is to provide an overview of the genetic basis of sex maintenance once the gonad is already differentiated.

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Section: Genes and Pathways Involved In The Maintenance Of The Female Cell Fatementioning

confidence: 99%

Section: Genes and Pathways Involved In The Maintenance Of The Female Cell Fatementioning

confidence: 99%

Sex Maintenance in Mammals

Jiménez

Burgos

Barrionuevo

2021

Genes

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“…Following VEGFA in the downregulated genes, is transforming growth factor-beta receptor 3 (TGF-BR3). Its protein TFGβ (also known as betaglycan), catalyzes endocrine hormones inhibin A and B to TGFβ whilst also inhibiting the activity of activin and bone morphogenetic proteins (BMPs) [20]. Activin promotes follicle stimulating hormone (FSH) secretion, whilst inhibin does the reverse, and therefore the expression of TGFBR3 must have a clear influence on the growth of the ovarian follicle [21].…”

Section: Discussionmentioning

confidence: 99%

New molecular markers involved in immune system homeostasis and hemopoietic organ development are differentially regulated during oocytes in vitro maturation

Moncrieff

Kocherova

Bryja

et al. 2020

Medical Journal of Cell Biology

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The growth and maturation of the oocyte is a dynamic process which requires a variable supply of hormones, growth factors and energy. These needs are met partially by the surrounding somatic cells and the cumulus-oocyte complex, which communicate bi-directionally via gap junctions. Identifying and analyzing protein expression in the oocyte can provide insight in its development and growth. Further, like bone marrow stem cells, if relevant marker genes are found in oocytes, there is a potential for the oocyte to be manipulated into becoming hemopoietic stem cells. In this study, porcine oocytes were isolated and subjected to microarray analysis to compare the oocyte gene expression in vivo and in vitro maturation (IVM). Genes identified belonged to both ‘hemopoietic or lymphoid organ development’(GO:0048534) and ‘immune system development’ (GO:0002520), and the markers can be used to identify several activities such as cell migration, neurogenesis and proliferation. The following are the identified genes and all were downregulated after IVM to varying degrees: ID2, VEGFA, TGFBR3, INHBA, CDK6, BCL11A, MYO1E, ITGB1, EGR1, NOTCH2, SPTA1, KIT and TPD52. Our results should provide new markers to further investigate oocyte development and growth regulation.Running title: Markers of hemopoietic organ development

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Association of body mass index with serum anti-Müllerian hormone and inhibin B levels among 8323 women attending a reproductive medical center: a cross-sectional study

Wang

Yang

et al. 2021

Endocrine

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Inhibin, Activin, and Follistatin in Ovarian Physiology

Cited by 4 publications

References 102 publications

Sex Maintenance in Mammals

Sex Maintenance in Mammals

New molecular markers involved in immune system homeostasis and hemopoietic organ development are differentially regulated during oocytes in vitro maturation

Association of body mass index with serum anti-Müllerian hormone and inhibin B levels among 8323 women attending a reproductive medical center: a cross-sectional study

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