Inhibin as a marker for ovarian cancer

Cooke, Inez; O’Brien, Martin; Charnock, F. M.; Groome, Nigel P.; Ganesan, T. S.

doi:10.1038/bjc.1995.201

Cited by 109 publications

(69 citation statements)

References 16 publications

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“…It seems that in the case of equine GTCT the inhibin α-subunit should also be considered as a marker for GTCT affected ovarian follicles. Some women affected by ovarian cancer can secrete both proα-C and inhibin A [5]. It may be assumed that in the case of equine GTCT the pattern of inhibin proα-C and inhibin A secretion from the affected ovarian follicles is similar to that in human ovarian cancer.…”

Section: Discussionmentioning

confidence: 99%

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Localization of Inhibin .ALPHA.-, .BETA.A- and .BETA.B-Subunits and Aromatase in Ovarian Follicles with Granulosa Theca Cell Tumor (GTCT) in 6 Mares

Hoque

Derar

Senba

et al. 2003

The Journal of Veterinary Medical Science

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ABSTRACT. To clarify the morphological and immunohistochemical characteristics in mares with granulosa theca cell tumor (GTCT), the localization of inhibin subunits (α, βA, βB) and aromatase in the granulosa cell layers and theca layers in the ovarian follicles were determined by immunohistochemical staining. The follicles were obtained from the ovaries of 6 mares with GTCT and 4 normal mares as controls. Immunohistochemically, inhibin α-subunit was localized in the granulosa cells of all follicles showing different sizes in all GTCT cases and βA-subunit was localized in two GTCT cases in all sized follicles. But inhibin βB-subunit and aromatase were not localized in GTCT cases. On the other hand, inhibin α-, βA-, and βB-subunits and aromatase were localized in the large and medium sized follicles, but inhibin βA-and βB-subunits and aromatase were not stained in the small sized follicles in normal cases. These findings suggest that some mares with GTCT can secrete dimeric inhibin (inhibin A), but all GTCT cases cannot secrete inhibin B. By the results of aromatase staining it is clear that testosterone is not converted into estradiol due to the lack of aromatase in the GTCT follicles.

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Section: Discussionmentioning

confidence: 99%

“…Inhibin α-subunit is considered a useful marker for ovarian cancer in humans and mares [1,5,7,8]. It seems that in the case of equine GTCT the inhibin α-subunit should also be considered as a marker for GTCT affected ovarian follicles.…”

Section: Discussionmentioning

confidence: 99%

Localization of Inhibin .ALPHA.-, .BETA.A- and .BETA.B-Subunits and Aromatase in Ovarian Follicles with Granulosa Theca Cell Tumor (GTCT) in 6 Mares

Hoque

Derar

Senba

et al. 2003

The Journal of Veterinary Medical Science

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“…Several reports indicate inhibin o-and S-subunit expression in gonadal sex-cord tumors (Gurusinghe et al, 1995;Flemming et al, 1995Flemming et al, ,1996Costa et al, 1997;Stewart et al, 1997;Yamashita et al, 1997;Zheng et al, 1997). In some cases, these tumors are associated with elevated circulating inhibin levels that are decreased following surgical resection (Lappohn et al, 1989;Silverman et al, 1994;Cooke et al, 1995;Yamashita et al, 1997). Serum FSH levels are inversely related to serum inhibin levels in some of these patients, indicating that the circulating inhibins are biologically active.…”

Section: Molecular Regulation Of Inhibin Subunitsmentioning

confidence: 99%

Mechanisms of Inhibin Signal Transduction

Bernard

Chapman²,

Woodruff³

2001

Recent Progress in Hormone Research

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Inhibin was first identified as a gonadal hormone that potently inhibits pituitary follicle-stimulating hormone (FSH) synthesis and secretion. Although the notion of a nonsteroidal, gonadally derived inhibitory substance was realized in the early 1930s (McCullagh, 1932) identification of the hormone was not accomplished until more than 50 years later. At that time, inhibin was purified from bovine and porcine follicular fluid and was shown to be produced in two forms through dimeric assembly of an Q subunit (I 8 kDa) and one of two closely related i3 subunits (PA and PB, approximately I4 kDa) Miyamoto et al., 1985;Rivier et al., 1985;Robertson et al., 1985).

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“…Increased serum concentrations of total inhibin were first discovered in patients with ovarian granulosa cell tumors (10). High serum concentrations of total inhibin were later measured also in patients with mucinous epithelial carcinomas of the ovary (11,12), whereas relatively low concentrations have been detected in other types of epithelial ovarian carcinomas (11)(12)(13)(14).…”

Section: Introductionmentioning

confidence: 99%

“…The function of pro-aC has not yet been ascertained, but its serum concentrations are known greatly to exceed those of inhibins A and B (13,18). Few data are available as to which molecular forms of inhibins are secreted into the circulation by different types of ovarian tumors (5,(11)(12)(13)(14), and the role and function of inhibins in the peritoneal fluid have not yet been clarified (19). Recent studies suggest that the a-subunit, rather than the dimeric forms, are increased in epithelial ovarian carcinomas, whereas ovarian granulosa cell tumors preferentially secrete dimeric inhibins (13,14).…”

Section: Introductionmentioning

confidence: 99%

Inhibin A, B and pro-alphaC in serum and peritoneal fluid in postmenopausal patients with ovarian tumors

Ala-Fossi

Mäenpää

Bläuer³

et al. 2000

European Journal of Endocrinology

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Objective: To compare serum and peritoneal fluid concentrations of inhibin A, B, and pro-aC in women with ovarian tumors. Methods: Serum and peritoneal fluid samples were taken from 41 postmenopausal women operated on for an ovarian tumor. Twenty-one patients with endometrial cancer formed a control group. Serum and peritoneal fluid inhibin A, B, and pro-aC concentrations, and serum FSH and tumor marker CA 125 (study group only) concentrations were analyzed. Results: Inhibin A was found in low concentrations (median 4.1 pg/ml, range < 2-29 pg/ml) in serum in most postmenopausal patients with epithelial ovarian carcinoma, whereas inhibin B was not measurable. Inhibin pro-aC circulated in high concentrations (median 125 pg/ml, range 37->1000 pg/ml). All inhibins were found in clearly greater concentrations in the peritoneal fluid than in serum. International Federation of Gynecology and Obstetrics (FIGO) stage III-IV and poor differentiation grade were associated with significantly lower concentrations of inhibin A and proaC in the peritoneal fluid compared with stages I-II or low grade. This correlation was not found in the serum concentrations of inhibin A or pro-aC. In the control group, no dimeric inhibins were found in serum, and pro-aC circulated in median concentrations of 47 pg/ml (range 12-174 pg/ml). Conclusions: Postmenopausal patients with epithelial ovarian tumors had low concentrations of inhibin A and relatively high concentrations of inhibin pro-aC in serum. The peritoneal fluid concentrations of all inhibins far exceeded those in the serum. Relatively low concentrations of inhibin A and pro-aC in the peritoneal fluid of patients with ovarian cancer seem to be associated with high stage and grade and, to a lesser degree, with positive peritoneal cytology.

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Inhibin as a marker for ovarian cancer

Cited by 109 publications

References 16 publications

Localization of Inhibin .ALPHA.-, .BETA.A- and .BETA.B-Subunits and Aromatase in Ovarian Follicles with Granulosa Theca Cell Tumor (GTCT) in 6 Mares

Localization of Inhibin .ALPHA.-, .BETA.A- and .BETA.B-Subunits and Aromatase in Ovarian Follicles with Granulosa Theca Cell Tumor (GTCT) in 6 Mares

Mechanisms of Inhibin Signal Transduction

Inhibin A, B and pro-alphaC in serum and peritoneal fluid in postmenopausal patients with ovarian tumors

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