Inhibition and Structural Changes of Liver Alkaline Phosphatase by Tramadol

Minai-Tehrani, Dariush; Eslami, Mahya; Khazaei, Nafsa; Katebian, Elmira; Azizi, Leila; Yazdi, Fatemeh; Hosseini, Akram Sadat; Taheri, MohammadReza

doi:10.2174/1872312808666140506093756

Cited by 3 publications

(1 citation statement)

References 20 publications

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“…According to our previous knowledge, MP compositions of n-hexane/ethanol/diethylamine and n-hexane/2-propanol/ diethyl-amine were used for isocratic separation of tramadol and propranolol, respectively. 10,11 A UV wavelength of detector was adjusted to 271 nm for tramadol and 290 nm for propranolol.…”

Section: Hplcmentioning

confidence: 99%

Optimization of throughput in semipreparative chiral liquid chromatography using stacked injection

Taheri

Fotovati

Hosseini³

et al. 2017

Chirality

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An interesting mode of chromatography for preparation of pure enantiomers from pure samples is the method of stacked injection as a pseudocontinuous procedure. Maximum throughput and minimal production costs can be achieved by the use of total chiral column length in this mode of chromatography. To maximize sample loading, often touching bands of the two enantiomers is automatically achieved. Conventional equations show direct correlation between touching-band loadability and the selectivity factor of two enantiomers. The important question for one who wants to obtain the highest throughput is "How to optimize different factors including selectivity, resolution, run time, and loading of the sample in order to save time without missing the touching-band resolution?" To answer this question, tramadol and propranolol were separated on cellulose 3,5-dimethyl phenyl carbamate, as two pure racemic mixtures with low and high solubilities in mobile phase, respectively. The mobile phase composition consisted of n-hexane solvent with alcohol modifier and diethylamine as the additive. A response surface methodology based on central composite design was used to optimize separation factors against the main responses. According to the stacked injection properties, two processes were investigated for maximizing throughput: one with a poorly soluble and another with a highly soluble racemic mixture. For each case, different optimization possibilities were inspected. It was revealed that resolution is a crucial response for separations of this kind. Peak area and run time are two critical parameters in optimization of stacked injection for binary mixtures which have low solubility in the mobile phase.

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Section: Hplcmentioning

confidence: 99%

Optimization of throughput in semipreparative chiral liquid chromatography using stacked injection

Taheri

Fotovati

Hosseini³

et al. 2017

Chirality

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Endogenous opiates and behavior: 2014

Bodnar

2016

Peptides

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Stereoselective Pharmacokinetics and Chiral Inversions of Some Chiral Hydroxy Group Drugs

Chen

Bai

Wang

et al. 2020

CPB

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Background: Chiral safety, especially chiral drug inversion in vivo, is the top priority of current scientific research. Medicine researchers and pharmacists often ignore that one enantiomer will be converted or partially converted to another enantiomer when it is ingested in vivo. So that, in the context that more than 50% of the listed drugs are chiral drugs, it is necessary and important to pay attention to the inversion of chiral drugs. Methods: The metabolic and stereoselective pharmacokinetic characteristics of seven chiral drugs with one chiral center in hydroxy group were reviewed by in vivo and in vitro include the possible chiral inversion of each drug enantiomer. These seven drugs include (S)-Mandelic acid, RS-8359, Tramadol, Venlafaxine, Carvedilol, Fluoxetine and Metoprolol. Results: The differences in stereoselective pharmacokinetic could be found for all the seven chiral drugs, since R and S isomers often exhibit different PK and PD properties. However, not every drug has shown the properties of one direction or two direction chiral inversion. For chiral hydroxyl group drugs, the redox enzyme system may be one of the key factors for chiral inversion in vivo. Conclusion: In vitro and in vivo chiral inversion is a very complex problem and may occur during every process of ADME. Nowadays, research on chiral metabolism in the liver has the most attention, while neglecting the chiral transformation of other processes. Our review may provide basis for the drug R&D and the safety of drugs in clinical therapy.

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Inhibition and Structural Changes of Liver Alkaline Phosphatase by Tramadol

Cited by 3 publications

References 20 publications

Optimization of throughput in semipreparative chiral liquid chromatography using stacked injection

Optimization of throughput in semipreparative chiral liquid chromatography using stacked injection

Endogenous opiates and behavior: 2014

Stereoselective Pharmacokinetics and Chiral Inversions of Some Chiral Hydroxy Group Drugs

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