Inhibition by coffee of nitrosourea-mediated DNA damage in mice

Aeschbacher, H.U.; Jaccaud, E.

doi:10.1016/0278-6915(90)90171-i

Cited by 32 publications

(14 citation statements)

References 31 publications

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“…[45614] However, the concentration of caffeine is of critical importance because high doses of caffeine induce apoptosis and low concentration can act as antioxidant. [252627] Furthermore, this study has demonstrated the suitability of non-mammalian in vivo assay for obtaining qualitative and quantitative data on antigenotoxic compounds.…”

Section: Resultsmentioning

confidence: 99%

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Protective effect of caffeine on Ethyl methanesulfonate-induced wing primordial cells of Drosophila melanogaster

Prakash¹,

Hosetti²,

Dhananjaya³

2014

Toxicol Int

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Objectives:The antimutagenic effect of caffeine is evaluated against ethyl methanesulfonate (EMS)-induced mutation rate in Drosophila.Materials and Methods:The mutation rate is evaluated using wing mosaic assay. In transheterozygous larvae, multiple wing hair (mwh 0.3-3) and flare (flr 3-38.8) genes were used as markers of the extent of mutagenicity.Results:The results at 0.5 and 1.0 mM EMS concentration at both 48 ± 4 and 72 ± 4 h have shown consistent increase in mutation rate, which was being measured as frequency of clone formation per 105 cells. Toxicity of caffeine at 5 mM concentration was parallel to that of distilled water alone. At 0.5 mM EMS concentration at 42 ± 4 and 72 ± 4 h, Drosophila larvae mutation rate was significantly increased. Although caffeine prevented mutation rate in all pre, post, and combined treatment, it was more significant in pretreatment experiments where it was found to be effective in reducing the genotoxicity of EMS. However, the concentration of caffeine as recommended in dietary allowance did not induce the frequency of mutant clones in somatic mutation and recombination test (SMART) recorded.Conclusion:This study shows that caffeine significantly reduced the genotoxicity induced by EMS. However, the limitation in completely abolishing genotoxicity induced by EMS as observed at the dietary allowance of caffeine makes it interesting for further in-depth study. Further studies on the molecular mechanism of antigenotoxic effect of caffeine will also be interesting.

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Section: Resultsmentioning

confidence: 99%

“…Caffeine acts as neurostimulator and exerts protective effect against genotoxic/carcinogenic activity of environmental chemicals in in vitro and in vivo assay system. [15678] These elaborate findings indicate caffeine is a chemopreventive drug against mutagens and carcinogens.…”

Section: Introductionmentioning

confidence: 99%

Protective effect of caffeine on Ethyl methanesulfonate-induced wing primordial cells of Drosophila melanogaster

Prakash¹,

Hosetti²,

Dhananjaya³

2014

Toxicol Int

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“… 28 Thus, they are strongly implicated to play a role in chemoprotection for inflammatory diseases and cancers. 29–31 CGA, an ester of caffeic acid and quinic acid, exerts anti‐inflammatory effect, reduces the mutagenic and genotoxic effects of cigarette tar and protects against DNA damage in mice 32,33 . Rutin, present in tea, fruit juices, and leaves of Ginkgo biloba , is known to break the oxidative chain reaction initiated by oxidized low‐density lipoproteins (LDL), and is chemoprotective for coronary heart diseases.…”

Section: Discussionmentioning

confidence: 99%

Naturally occurring polyphenolic antioxidants modulate IgE‐mediated mast cell activation

et al. 2000

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SUMMARYReactive oxygen species (ROS) are known to modulate activities of a host of kinases, phosphatases and transcription factors. Rutin and chlorogenic acid (CGA) are the major polyphenolic antioxidants present in the small molecular fraction of smokeless tobacco leaf extracts, as ascertained by reverse-phase high-pressure liquid chromatography (HPLC) and mass spectrometry. Levels of intracellular ROS in resting versus antigen±immunoglobulin E (IgE)-challenged murine mast cells were measured at 510 nm by¯uorescence-activated cell sorting (FACS) using carboxydichloro¯uorescein (DCFH-DA). Enhanced ROS production was observed in IgE-sensitized mast cells following antigenic challenge. Rutin and CGA reduced ROS levels in antigen±IgE-activated mast cells. Concomitantly, they also profoundly inhibited histamine release by these activated mast cells. In contrast, rutin and CGA augmented the inducible cytokine messages, i.e. interleukin (IL)-10, IL-13, interferon-c (IFN-c), IL-6 and tumour necrosis factor-a (TNF-a) in IgE-sensitized mast cells following antigen challenge. This study indicates that tobacco polyphenolic antioxidants that quench intracellular ROS, differentially affect two effector functions of antigen±IgE-activated mast cells. This model system may be employed to determine the molecular target of polyphenols. The potential role of these polyphenolic antioxidants on IgE-mediated allergy in vivo depends on a balance of their differential effects on mast cell activation.

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“…Caffeine and polyphenolic compounds that are present in relatively high levels in the plant beverages, including chlorogenic acids and their degradation products, have been considered as good candidates for a protective effect/role of coffee [40,41]. Svilaas et al [42] determined the contribution of various food groups to total antioxidant intake in humans, measured by a FRAP (ferric reducing ability of plasma) assay, and assessed the correlation of the total antioxidant intake from the food groups with plasma antioxidants.…”

Section: Antioxidantsmentioning

confidence: 99%

Coffee consumption and human health - beneficial or detrimental? - Mechanisms for effects of coffee consumption on different risk factors for cardiovascular disease and type 2 diabetes mellitus

Ranheim

Halvorsen

2005

Mol. Nutr. Food Res.

231

169

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Coffee is probably the most frequently ingested beverage worldwide. Especially Scandinavia has a high prevalence of coffee-drinkers, and they traditionally make their coffee by boiling ground coffee beans and water. Because of its consumption in most countries in the world, it is interesting, from both a public and a scientific perspective, to discuss its potential benefits or adverse aspects in relation to especially two main health problems, namely cardiovascular disease and type 2 diabetes mellitus. Epidemiological studies suggest that consumption of boiled coffee is associated with elevated risk for cardiovascular disease. This is mainly due to the two diterpenes identified in the lipid fraction of coffee grounds, cafestol and kahweol. These compounds promote increased plasma concentration of cholesterol in humans. Coffee is also a rich source of many other ingredients that may contribute to its biological activity, like heterocyclic compounds that exhibit strong antioxidant activity. Based on the literature reviewed, it is apparent that moderate daily filtered, coffee intake is not associated with any adverse effects on cardiovascular outcome. On the contrary, the data shows that coffee has a significant antioxidant activity, and may have an inverse association with the risk of type 2 diabetes mellitus.

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Inhibition by coffee of nitrosourea-mediated DNA damage in mice

Cited by 32 publications

References 31 publications

Protective effect of caffeine on Ethyl methanesulfonate-induced wing primordial cells of Drosophila melanogaster

Protective effect of caffeine on Ethyl methanesulfonate-induced wing primordial cells of Drosophila melanogaster

Naturally occurring polyphenolic antioxidants modulate IgE‐mediated mast cell activation

Coffee consumption and human health - beneficial or detrimental? - Mechanisms for effects of coffee consumption on different risk factors for cardiovascular disease and type 2 diabetes mellitus

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