Inhibition efficiency of a newly isolated flavonoid compound from Vitex negundo L. leaves against cattle-endosymbiont Setaria cervi : Phytomedicine for lymphatic filariasis

Rana, Gopinath

doi:10.1016/j.parepi.2018.03.002

Cited by 12 publications

(6 citation statements)

References 17 publications

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“…This explains the sometimes unjustifiably high mortality from this disease, which, with its timely detection and preventive measures, does not seem so dangerous for domestic cattle. A recent study by G. Rana (2018) has confirmed the fact of the relative abundance of pathogens of this disease, which is partly explained by the difficulties with their classification and variability conditioned by the combination of many factors that determine both the nature of the course of the disease and the peculiarity of infection of animals of specific groups.…”

Section: Discussionmentioning

confidence: 88%

Study of the Dynamics of Distribution, Seasonality, and Degree of Infection with Bovine Theileriosis in the Territory of Turkestan Region

2022

Int J Vet Sci

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The relevance of the study is conditioned by the need for rational planning and timely implementation of therapeutic and preventive measures with cattle in various geographical regions, to prevent the spread of ticks and to form an objective understanding of the real features of the epizootic situation in these regions. The purpose of the study is to investigate the dynamics of the spread, the seasonality, and the degree of infection with bovine theileriosis in the Turkestan Region of the Republic of Kazakhstan. The leading approach is a combination of the method of determining the species composition of ixodic mites using the technique developed by V.I. Pomerantsev, with a practical investigation of the seasonality of the spread of ticks, through a survey of various pastures, and regular collection of ticks from cattle during a certain period of the pasture season in stationary points, to establish the species composition of ticks and the degree of contamination of pastures. The research was carried out using the capabilities of the laboratory of the Department of Veterinary Medicine of the regional veterinary laboratory and on the farms of the Turkestan Region. Practical results were obtained in the course of this study, indicating the main trends in the dynamics of the spread, seasonality, and degree of infection with bovine theileriosis in the territory of the Turkestan Region and the country as a whole. The study results and the conclusions formulated on their basis have significant practical significance for livestock workers of the Turkestan Region of Kazakhstan, whose professional duties include monitoring the condition of cattle on these farms and preventing the occurrence and spread of various epidemics among animals.

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Section: Discussionmentioning

confidence: 88%

Study of the Dynamics of Distribution, Seasonality, and Degree of Infection with Bovine Theileriosis in the Territory of Turkestan Region

2022

Int J Vet Sci

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“…More than 17,500 aromatic plant species produce EOs, including Lamiaceae, Rutaceae, Myrtaceae, Zingiberaceae, and Asteraceae [22]. The essential oil of V. negundo has the highest larvicidal activity against A. aegypti due to containing various polyphenolic compounds as active ingredients [20] and active constituents of V. negundo L. are polyphenolics, flavonoids, that are usually active antioxidants [23,24]. Rana [24] has studied that, the inhibition efficiency of active principal compound 4,5-diethyl-3′-ethoxy-pyro-flavone, derived from a methanolic extract of V. negundo L., has demonstrated promising macrofilaricidal activity against the adult filarial worm Setaria cervi.…”

Section: Discussionmentioning

confidence: 99%

Bio-efficacy of Karu Nochi, Vitex negundo L. (Lamiaceae) against the dengue vector, Aedes aegypti (L.)

Chechi¹,

Kumar²,

Prabhu³

et al. 2022

GSC Adv. Res. Rev.

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The dengue vector, Aedes aegypti (L.) is one of the world's deadliest species and it spreads diseases like Zika, chikungunya, dengue, and yellow fever. In this present investigation, we attempt to evaluate the larvicidal toxicity of different solvent extracts and essential oil of Karunochi, Vitex negundo (L.) on third instar larvae of the dengue vector, A. aegypti. The crude extracts were prepared by using soxhlet apparatus and rotary vacuum evaporator technique. The highest mortality was observed in essential oil and ethanolic extract followed by hexane and acetone extracts, the lethal concentrations LC50 (LC90) values were obtained from noticed, for Vn-EO- 218.46 (517.10), Vn-EE 268.37 (592.56), Vn-HE 309.59 (667.33), and Vn-AE 327.88 (748.47), respectively and nil mortality observed in the control treatment. Karunochi, V. negundo essential oil, and ethanolic extract (Vn-EE) were more efficient against A. aegypti than crude extracts of Vn-AE (acetone) and Vn-HE (hexane). Therefore, from our studies the formulations are promising for a low-cost larvicide without isolating an active ingredient, EO’s were tested. The goal of this study is to promote the use of plant-based larvicides in public health programmes.

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“…In V . negundo L., there was one flavonoid assigned as 4,5-diethyl-3′-ethoxy-pyro-flavone ( 127 ) [ 24 ]. Compound 127 demonstrated significant in vitro antifilarial activity in a dose-dependent manner against adult Setaria cervi worms, as measured by worm motility and MTT reduction assays.…”

Section: Secondary Metabolites Isolated From Vitex ...mentioning

confidence: 99%

“…Some of the bioactive compounds of Vitex noted to be responsible for its anti-inflammatory activity are iridoid and pedunculariside, where they were found to demonstrate preferential inhibition of COX-2 and little inhibitory effect on COX-1 [ 21 , 22 ]. Flavonoids extracted from Vitex also contributed to several pharmacological benefits of the plant, such as the antifungal activity, trypanocidal activity, and anti-filarial properties [ 23 , 24 , 25 ]. In addition, diterpenoid and triterpenoid are also some of the constituents found in the Vitex genus to exhibit anti-proliferative properties, cytotoxic activity, and demonstrated a dopaminergic effect [ 26 , 27 , 28 , 29 ].…”

Section: Introductionmentioning

confidence: 99%

Traditional Medicinal Uses, Phytochemistry, Biological Properties, and Health Applications of Vitex sp.

Kamal

Asni

Rozlan

et al. 2022

Plants

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The genus Vitex is also known as a chaste tree, in which it is a large shrub native to the tropical and subtropical regions of the world. A diverse range of species is distributed throughout Southern Europe, the Mediterranean, and Central Asia. The Vitex tree, including its leaves and fruits, has been used for herbal remedies in the form of pastes, decoctions, and dried fruits since ancient times. This article aimed to prepare a comprehensive review of traditional uses and secondary metabolites derived from Vitex sp., including the chemical compounds, biological activities, application of Vitex in human clinical trials, toxicology and safety, marketed products, and patents. The scientific findings were obtained using a number of search engines and databases, including Google Scholar, PMC, and ScienceDirect. Vitex species are well known in pharmacology to have medicinal values, such as anti-inflammatory, antibacterial, antifungal, antimicrobial, antioxidant, and anticancer properties. Previous studies reported that some species are proven to be effective in treating diseases, such as diabetes, and improving female health. A total of 161 compounds from different Vitex species are reported, covering the literature from 1982 to 2022. A chemical analysis report of various studies identified that Vitex exhibited a wide range of phytoconstituents, such as iridoid, diterpenoid, ecdysteroid, and flavonoid and phenolic compounds. Apart from that, the review will also discuss the application of Vitex in human clinical trials, toxicology and safety, marketed products, and patents of the genus. While the extracts of the genus have been made into many commercial products, including supplements and essential oils, most of them are made to be used by women to improve menstrual conditions and relieve premenstrual syndrome. Among the species, Vitex agnus-castus L. is the only one that has been reported to undergo clinical trials, mainly related to the use of the genus for the treatment of mastalgia, menstrual bleeding problems, amenorrhea, menorrhagia, luteal insufficiency, and premenstrual syndrome. Overall, the review addresses recent therapeutic breakthroughs and identifies research gaps that should be explored for prospective research work.

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Inhibition efficiency of a newly isolated flavonoid compound from Vitex negundo L. leaves against cattle-endosymbiont Setaria cervi : Phytomedicine for lymphatic filariasis

Cited by 12 publications

References 17 publications

Study of the Dynamics of Distribution, Seasonality, and Degree of Infection with Bovine Theileriosis in the Territory of Turkestan Region

Study of the Dynamics of Distribution, Seasonality, and Degree of Infection with Bovine Theileriosis in the Territory of Turkestan Region

Bio-efficacy of Karu Nochi, Vitex negundo L. (Lamiaceae) against the dengue vector, Aedes aegypti (L.)

Traditional Medicinal Uses, Phytochemistry, Biological Properties, and Health Applications of Vitex sp.

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