Inhibition<i>in Vitro</i>of Adrenal Pregnenolone Biosynthesis by Amphenone and Its Analogues

Kibelstis, John A.; Ferguson, James J.

doi:10.1210/endo-74-4-567

Cited by 12 publications

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“…Similar results were obtained by means of using exogenous cholesterol and monitoring isocaproic acid production by adrenal homogenates (Kitay 1968;Colby and Kitay 1972). On the contrary, stilbestrol inhibits side-chain cleavage of cholesterol in the extracts of steer adrenals (Kibelstis and Ferguson 1964). Also, the concentration of cytochrome P-450 in the adrenal mitochondria is lower in testosterone treated animals, whereas estradiol increases this concentration (Brownie, Colby, Galant and Skelton 1970;Colby, Skelton and Brownie 1970;Kramer, Greiner and Colby 1975).…”

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confidence: 74%

Sex Difference in Adrenocortical Structure and Function. VII. Adrenal Sterol Ester Hydrolase Activity in the Rat and its Dependence on Gonadal Hormones

Wh¹,

Lk²

1981

Horm Metab Res

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The effect of gonadectomy and gonadal hormone replacement on the activity of sterol ester hydrolase, steroid 5a-reductase and corticosterone output was studied in the adrenals of rats of both sexes.It was found that the specific activity of sterol ester hydrolase in 105,000 x g supernatant of the adrenal homogenates was higher in male than in female rats. On the contrary, corticosterone production by full adrenal homogenates, and adrenal steroid 5a-reductase activity was lower in male than in female rats.Eight weeks after orchiectomy no change in the activity of sterol ester hydrolase was found in the adrenal cortex, and testosterone replacement caused no appreciable differences in the enzymic activity as compared with the intact and orchiectomized animals. Ovariectomy resulted in an increase in the activity of sterol ester hydrolase whereas estradiol replacement caused a decrease in the enzymic activity to the level observed in the control group.In gonadectomized animals these changes accompanied an increase of steroid 5a-reductase activity in the adrenal glands, and after removal of the gonads no changes were found in corticosterone production by adrenal homogenates. Upon testosterone or estradiol replacement a substantial decrease in adrenal steroid 5a-reductase activity was noted.The results showed a marked sex difference in adrenal sterol ester hydrolase activity and indicate diverse effects of both testosterone and estradiol on various steps of steroidogenesis in rat adrenals.

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Section: Discussionsupporting

confidence: 74%

Sex Difference in Adrenocortical Structure and Function. VII. Adrenal Sterol Ester Hydrolase Activity in the Rat and its Dependence on Gonadal Hormones

Wh¹,

Lk²

1981

Horm Metab Res

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Über die adrenale Steroid‐Biosynthese in vitro. III. Selektive Hemmung der Nebennierenrinden‐Funktion

Kahnt

Neher

1966

Helvetica Chimica Acta

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Volumen 49, Fasciculus 1 (1966) -No. 82-83 725 azides with an hexapeptide. The two latter have been obtained from the hexapeptide by the recurring method, using active trichlorophenyl esters.Comparison of the biological activities of these compounds with those of the corresponding analogues still bearing the a-amino group shows that suppression of this amino group decreases the pressoric/antidiuretic ratio of these compounds.Laboratoires de Chimie pharmaceutique SANDOZ S. A., BAle BIBLIOGRAPHIE

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Modifiers of steroid-hormone metabolism: a review of their chemistry, biochemistry and clinical applications

Gower

1974

Journal of Steroid Biochemistry

142

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Inhibitionin Vitroof Adrenal Pregnenolone Biosynthesis by Amphenone and Its Analogues

Cited by 12 publications

References 0 publications

Sex Difference in Adrenocortical Structure and Function. VII. Adrenal Sterol Ester Hydrolase Activity in the Rat and its Dependence on Gonadal Hormones

Sex Difference in Adrenocortical Structure and Function. VII. Adrenal Sterol Ester Hydrolase Activity in the Rat and its Dependence on Gonadal Hormones

Über die adrenale Steroid‐Biosynthese in vitro. III. Selektive Hemmung der Nebennierenrinden‐Funktion

Modifiers of steroid-hormone metabolism: a review of their chemistry, biochemistry and clinical applications

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