Inhibition of 2,4-dinitrofluorobenzene-induced atopic dermatitis by topical application of the butanol extract of Cordyceps bassiana in NC/Nga mice

Wu, Guang; Li, Lan; Sung, Gi Ho; Kim, Tae‐Woong; Byeon, Se Eun; Cho, Jae Youl; Park, Chun Wook; Park, Hyoung Jin

doi:10.1016/j.jep.2010.12.012

Cited by 38 publications

(25 citation statements)

References 31 publications

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“…This disease, in recent years, has been reported to be affecting 10-20% of children and 1-2% of adults. Although the physiological mechanism of the disease is not fully understood, the overproduction of inflammatory mediators such as IL 1␤, IL-6, IL-8, TNF-␣ by pro-inflammatory cells, like the macrophages, have been known to be the major cause (Wu et al, 2011). Ukawa et al (2007) reported that Lyophyllum decastes (Fr.)…”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

Mushrooms extracts and compounds in cosmetics, cosmeceuticals and nutricosmetics—A review

Taofiq

González-Paramás

Martins

et al. 2016

Industrial Crops and Products

158

114

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a b s t r a c tThe cosmetic industry is constantly in search of ingredients from natural sources because of their competitive effectiveness and lower toxicity effects. Mushrooms have been an important part of our diet for years and are now finding their way as cosmetic ingredients, either as cosmeceutical or as nutricosmetics. The present review focuses on the most relevant activities of mushroom extracts, as well as on their bioactive compounds, which make them interesting ingredients for cosmetic formulations. Mushroom extracts, as well as their bioactive metabolites, revealed anti-tyrosinase, anti-hyaluronidase, anti-collagenase and anti-elastase activity. Emphasis was also given to their important anti-oxidant, antimicrobial and antiinflammatory potential, topics largely studied by numerous authors, making them very versatile and multi-functional cosmetic ingredients. Some of the bioactive compounds and the mechanism responsible for the activities ascribed to mushrooms were highlighted. Other activities were identified as needing to be further studied in order to identify the major compounds contributing to the target activity, as well as their mechanisms of action. Based on the above findings, mushroom extracts, as well as their bioactive metabolites, constitute important ingredients that can help to combat aging, reduce the severity of inflammatory skin disease and correct hyperpigmentation disorders. These findings and claims must be correctly supported by clinical trials and in vivo studies.

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Section: Anti-inflammatory Activitymentioning

confidence: 99%

Mushrooms extracts and compounds in cosmetics, cosmeceuticals and nutricosmetics—A review

Taofiq

González-Paramás

Martins

et al. 2016

Industrial Crops and Products

158

114

View full text Add to dashboard Cite

show abstract

“…These results strongly implied that the artificially cultivated fruit bodies exhibit similar pharmacological activity as the natural forms of this mushroom. Indeed, we previously observed that the artificially cultivated fruit body of Cordyceps bassiana can effectively treat symptoms of atopic dermatitis [41]. Moreover, the artificially cultivated fruit body of Cordyceps militaris possesses antihepatitis activity (data not shown).…”

Section: Discussionmentioning

confidence: 92%

IKKβ‐Targeted Anti‐Inflammatory Activities of a Butanol Fraction of Artificially Cultivated Cordyceps pruinosa Fruit Bodies

Kim

Yang

Sung

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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The inhibitory activities of the Cordyceps pruinosa butanol fraction (Cp-BF) were investigated by determining inflammatory responses of lipopolysaccharide (LPS)-treated RAW264.7 macrophage cells and by evaluating HCl/ethanol (EtOH)-triggered gastric ulcers in mice. The molecular mechanisms of the inhibitory effects of Cp-BF were investigated by identifying target enzymes using biochemical and molecular biological approaches. Cp-BF strongly inhibited the production of NO and TNF-α, release of reactive oxygen species (ROS), phagocytic uptake of FITC-dextran, and mRNA expression levels of interleukin (IL)-6, inducible NO synthase (iNOS), and tumour necrosis factor-alpha (TNF)-α in activated RAW264.7 cells. Cp-BF also strongly downregulated the NF-κB pathway by suppressing IKKβ according to luciferase reporter assays and immunoblot analysis. Furthermore, Cp-BF blocked both increased levels of NF-κB-mediated luciferase activities and phosphorylation of p65/p50 observed by IKKβ overexpression. Finally, orally administered Cp-BF was found to attenuate gastric ulcer and block the phosphorylation of IκBα induced by HCl/EtOH. Therefore, these results suggest that the anti-inflammatory activity of Cp-BF may be mediated by suppression of IKKα and its downstream NF-κB activation. Since our group has established the mass cultivation conditions by developing culture conditions for Cordyceps pruinosa, the information presented in this study may be useful for developing new anti-inflammatory agents.

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“…For induction of atopic dermatitis, 150 mL of 0.5% 2.4-dinitrofluorobenzene (DNFB) in acetone/olive oil (3:1) was repeatedly applied on the shaved skin of the dorsal area two times a week for 4 weeks (Wu et al, 2011). After the induction of atopic dermatitis, formulations (liposome in gel, nanoparticle in gel, commercial cream) were topically applied on the skin lesion two times a day during 12 days.…”

Section: Treatment Efficacy Of Formulationsmentioning

confidence: 99%

Effective topical delivery systems for corticosteroids: dermatological and histological evaluations

et al. 2014

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Atopic dermatitis (AD) is a chronic and relapsing skin disease with severe eczematous lesions. Long-term topical corticosteroid treatment can induce skin atrophy, hypopigmentation and transepidermal water loss (TEWL) increase. A new treatment approach was needed to reduce the risk by dermal targeting. For this purpose, Betamethasone valerate (BMV)/Diflucortolone valerate (DFV)-loaded liposomes (220-350 nm) were prepared and incorporated into chitosan gel to obtain adequate viscosity ($13 000 cps). Drugs were localized in stratum corneum + epidermis of rat skin in ex-vivo permeation studies. The toxicity was assessed on human fibroblast cells. In point of in-vivo studies, pharmacodynamic responses, treatment efficacy and skin irritation were evaluated and compared with previously prepared nanoparticles. Liposome/ nanoparticle in gel formulations produced higher paw edema inhibition in rats with respect to the commercial cream. Similar skin blanching effect with commercial creams was obtained via liposome in gels although they contain 10 times less drug. Dermatological scoring results, prognostic histological parameters and suppression of mast cell numbers showed higher treatment efficiency of liposome/nanoparticle in gel formulations in AD-induced rats. TEWL and erythema measurements confirmed these results. Overview of obtained results showed that liposomes might be an effective and safe carrier for corticosteroids in skin disease treatment.

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Inhibition of 2,4-dinitrofluorobenzene-induced atopic dermatitis by topical application of the butanol extract of Cordyceps bassiana in NC/Nga mice

Cited by 38 publications

References 31 publications

Mushrooms extracts and compounds in cosmetics, cosmeceuticals and nutricosmetics—A review

Mushrooms extracts and compounds in cosmetics, cosmeceuticals and nutricosmetics—A review

IKKβ‐Targeted Anti‐Inflammatory Activities of a Butanol Fraction of Artificially Cultivated Cordyceps pruinosa Fruit Bodies

Effective topical delivery systems for corticosteroids: dermatological and histological evaluations

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