Inhibition of Acinetobacter baumannii biofilm formation on a methacrylate polymer containing a 2-aminoimidazole subunit

Abstract

A polymeric composite containing a 2-aminoimidazole derivative was synthesized. It was found that this polymer was resistant to biofilm colonization by Acinetobacter baumannii, no leaching of the 2-aminoimidazole derivative was observed after 2 weeks of treatment with deionized water, and the resulting polymer was not hemolytic.

Amide side chain amphiphilic polymers disrupt surface established bacterial bio-films and protect mice from chronic Acinetobacter baumannii infection

“…Although a variety of antibacterial polymers has been reported, the ability of polymers to disrupt surface established bacterial biofilms have been scarce. Melander et al have shown methacrylate polymers containing 2-aminoimidazle subunit that inhibit A. baumannii biofilm formation [36]. Hedrick and co-workers demonstrated antimicrobial polymeric hydrogels that can disrupt bacterial and fungal biofilms [37].…”

Identification of BfmR, a Response Regulator Involved in Biofilm Development, as a Target for a 2-Aminoimidazole-Based Antibiofilm Agent

“…1a. This molecule has demonstrated great efficacy in affecting A. baumannii in both its biofilm and planktonic states 12,22 23. .…”

Nanoparticles for Control of Biofilms of Acinetobacter Species

“…These polymers also reduce the bacterial count in mice with chronic burn-wound infection [88]. Similar observation was seen with methacrylate polymers containing a 2-aminoimidazole subunit [112]. Chitosan nanoparticles act as adjuvant to carry outer membrane proteins of Acinetobacter and elicit excellent immune response in rats [92], indicating potential for developing a novel vaccine.…”

“…Properties of biocompatible polymers can also be harnessed for in vivo applications. However, very few reports are available on inhibition and disruption of Acinetobacter biofilms through polymers [92,112]. Maleic anhydride-based amphiphillic polymers, containing amide side chains, disrupt surface established A. baumannii biofilms.…”