Nanoparticles for Control of Biofilms of Acinetobacter Species

Abstract

Biofilms are the cause of 80% of microbial infections. Acinetobacter species have emerged as multi- and pan-drug-resistant bacteria and pose a great threat to human health. These act as nosocomial pathogens and form excellent biofilms, both on biotic and abiotic surfaces, leading to severe infections and diseases. Various methods have been developed for treatment and control of Acinetobacter biofilm including photodynamic therapy, radioimmunotherapy, prophylactic vaccines and antimicrobial peptides. Nanotechnology, in the present scenario, offers a promising alternative. Nanomaterials possess unique properties, and multiple bactericidal mechanisms render them more effective than conventional drugs. This review intends to provide an overview of Acinetobacter biofilm and the significant role of various nanoparticles as anti-biofouling agents, surface-coating materials and drug-delivery vehicles for biofilm control and treatment of Acinetobacter infections.

Acinetobacter sp. mediated synthesis of AgNPs, its optimization, characterization and synergistic antifungal activity against C. albicans

“…; Jagtap et al , ; Jagtap and Chopade ), rhizosphere soil (Sachdev et al ; Maindad et al ; Mujumdar et al ), waste water and activated sewage sludge (Shakibaie et al ; Wadhwani et al ), and hospitals (Patwardhan et al ). It possesses excellent biofilm forming capacity and exhibiting high level of metal resistance and antibiotic resistance (Deshpande and Chopade ; Shakibaie et al ; Sahu et al ; Gaidhani et al ; Singh et al ). Acinetobacter sp.…”

Design and Assessment of Anti-Biofilm Peptides: Steps Toward Clinical Application

“…Silver nanoparticles, for example, have been used to eradicate up to 99% of A. baumannii biofilms in vitro [63]. Nanoparticles also have potential to be synergistically linked to antimicrobial agents to decrease treatment load and toxicity while increasing effectiveness of the treatment [62,64]. Chen and colleagues, for example, designed nickel magnetic nanoparticles linked to LL-37 and used them to treat established E. coli biofilms in vitro [64].…”

“…Metal nanoparticles such as nickel, silver, and gold have been used as antimicrobial treatments in vitro and have potent activity against biofilms [62,63]. Silver nanoparticles, for example, have been used to eradicate up to 99% of A. baumannii biofilms in vitro [63].…”

Green synthesis of selenium nanoparticles using<em> Acinetobacter</em> sp. SW30: optimization, characterization and its anticancer activity in breast cancer cells

“…[15][16][17][18][19][20][21] They have excellent biofilm-forming capability. [22][23][24][25] They have high degree of antibiotic and metal resistance. 16,26,27 Acinetobacter is known to synthesize gold, silver and platinum NPs.…”