Inhibition of adenosine 3',5'-cyclic monophosphate phosphodiesterase by flavonoids. II.

Effects of Long-Term Administration of Hesperidin and Glucosyl Hesperidin to Spontaneously Hypertensive Rats.

“…These short-term effects may be explained by stimulated di uresis (7). Various flavanones serve as an inhibitor of cyclic AMP phosphodiesterase responsible for diuresis (10). Another study has showed that methylhesperi din reduces blood pressure and that this effect arises from the inhibition of voltage-dependent Ca2+ channel and Ca2+ release generated by norepinephrine (11) .…”

Skullcap Scutellaria lateriflora L.: An American nervine

“…in the bronchi or coronary arteries, is through inhibition of cAMP phosphodiesterase. Baicalein and other Scutellaria flavones have shown potent cAMP phosphodiesterase inhibition in vitro (Nikaido et al, 1988).…”

Structural Requirements of Flavonoids and Related Compounds for Aldose Reductase Inhibitory Activity.

“…[26][27][28] Apigenin (8), 29) diosmetin (13), 29) kaempferol (22), 29) quercetin (24), 29) 30, 30) and 48 31) were derived by methanolysis of 10, 19, 23, 38, 41, 32) and 54, respectively. The following derivatives were prepared by diazomethane methylation: 9 33) was prepared from 8; pilloin (14) 34) and 15 35) from luteolin (12); rhamnetin (25), 36) tamarixetin (26), 37) 27, 38) ombuine (28), 36,37) ayanin (29), 37) and 31 39) from 24; rhamnetin 3-O-rutinoside (39), 40) ombuine 3-O-rutinoside (40), 41) 47) and 49 43) were derived by methyl iodide (CH 3 I) methylation of 12, 24, and 43, respectively.…”