Inhibition of Advanced Glycation End Products Formation by Mangifera indica Leaf Extract

Itoh, Kimihisa; Murata, Kazuya; Sakaguchi, Nobuki; Akai, Kohei; Yamaji, Tomoka; Shimizu, Kosuke; Isaki, Kaoru; Matsukawa, Tetsuya; Kajiyama, Shin’ichiro; Fukuda, Masahiko; Iijima, Morio; Matsuda, Hideaki

doi:10.5539/jps.v6n2p102

Cited by 8 publications

(19 citation statements)

References 19 publications

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“…Of note, these results are consistent with previous published studies highlighting the strong anti-AGEs capacity of xanthone derivatives and flavonoid glycosides (Abdallah et al, 2017;Derbré et al, 2010). More precisely, the potent antiglycation activities of compounds 3, 5 and 6 have been previously reported by two distinct studies (Itoh et al, 2017;Kim et al, 2011) using glucose or fructose as reducing sugars. By contrast, data regarding benzophenone constituents are scarcer and the noticeable antiglycation activity of compound 4 is firstly reported.…”

Section: Resultssupporting

confidence: 93%

“…Author(s) agree that this article remain permanently open access under the terms of the Creative Commons Attribution License 4.0 International License activity of mango leaves has already been reported by different studies (Pereira et al, 2007;Fernández-Ponce et al, 2012;Ling et al, 2009). By contrast, very limited investigations have been done regarding inhibitory effects on the formation of advanced glycation end products (AGEs) (Itoh et al, 2017). AGEs are the final products of a nonenzymatic reaction, also known as Maillard reaction, occurring between reducing sugars and nucleic acids, lipids or free amino groups of proteins.…”

Section: Introductionmentioning

confidence: 84%

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Bio-guided identification of antiglycative constituents from the leaves of Mangifera indica L.

Ndoye¹,

Fraisse²,

AkendenguÃ³

et al. 2019

J. Med. Plants Res.

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Advanced glycation end-products (AGEs) have been shown to be implicated in many degenerative disorders as well as diabetic pathology. Of interest, several natural compounds including phenolic constituents are capable of inhibiting the formation of AGEs. Bio-guided fractionation of a methanol extract from Mangifera indica leaves led to the characterization of six antiglycative constituents including gallic acid (1), iriflophenone-3-C-β-D-glucoside (2), mangiferin (3), iriflophenone-3-C-(2'-Ogalloyl)-β-D-glucoside (4), hyperoside (5) and isoquercitrin (6). With IC 50 values lower than that of aminoguanidine, the six identified phenolic compounds can be regarded as remarkable inhibitors of advanced glycation end products formation and M. indica leaves should be considered as a potential nutraceutical resource to prevent carbonyl stress-related diseases.

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Section: Resultssupporting

confidence: 93%

Section: Introductionmentioning

confidence: 84%

Bio-guided identification of antiglycative constituents from the leaves of Mangifera indica L.

Ndoye¹,

Fraisse²,

AkendenguÃ³

et al. 2019

J. Med. Plants Res.

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“…Spectrophotometric determination of the content of 3 (mg/g extract) was carried out according to the method given by Porra, Thompson, and Kriedemann (1989). The content of total anthocyanin (μg/g extract) in each leaf extract was determined by the HPLC analysis described in a previous paper (Itoh et al, 2017).…”

Section: Determination Of Content Of 1 2 3 and 4 In Each Mango Cultivar Leaf Extractmentioning

confidence: 99%

In vitro Antioxidant Activity of Mangifera indica Leaf Extracts

Itoh¹,

Matsukawa²,

Okamoto³

et al. 2020

JPS

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In this study, we aimed to identify the utility of pruned mango (Mangifera indica ‘Irwin’) leaves as a resource for ingredients with antioxidant activity. Firstly, we examined the antioxidant activity of extracts obtained from the pericarps, flesh, flowers, barks, seeds, young dark reddish brown leaves (YDL-ext), young yellow leaves (YYL-ext), and pruned old dark green leaves (OML-ext) obtained from ‘Irwin’ mango. Among them, methanolic extract of flower and OML-ext showed the most potent 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging and superoxide dismutase (SOD)-like activity. The flesh extract showed weak DPPH radical scavenging activity, but did not show SOD-like activity. Secondly, we investigated the relationship between the maturation of leaves and their antioxidant activity by considering the contents of their two active polyphenolic components, 3-C-β-D-glucosyl-2,4,4’,6-tetrahydroxybenzophenone (1) and mangiferin (2), in addition to chlorophyll (3) and anthocyanins represented by cyanidin-3-O-glucoside (4). The DPPH radical scavenging activity of YDL-ext, YYL-ext and OML-ext were mainly attributable to 1, 2 and 3, whereas their SOD-like activity was partly attributable to 2. The DPPH radical scavenging and SOD-like activities of YDL-ext and YYL-ext were attributable to 1 and 2. These activities were also due to anthocyanins whose content is highest in YDL-ext. Considering the amounts of leaves obtained from pruning, old dark green leaves may be a reasonable natural resource for preparing cosmetics and/or supplemental ingredients with health-enhancing properties, antioxidant activity and inhibitory effect on AGEs formation and pancreatic lipase.

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“…Suppression activity of AGEs production was measured according to the method of Shimoda et al 25 and Itoh et al 26 with minor modifications. The test sample was dissolved with DMSO and diluted with sodium phosphate buffer (0.2 M KH 2 PO 4 , 0.2 M NaOH, pH 7.2) to a final DMSO concentration of 1% v/v.…”

Section: Methodsmentioning

confidence: 99%

Anti-tyrosinase and Anti-oxidative Activities by Asana: the Heartwood of Pterocarpusmarsupium

Deguchi

Tamai

Asahara

et al. 2019

Natural Product Communications

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Asana (the heartwood of Pterocarpus marsupium) has been utilized as an agent for diabetes mellitus in Ayurveda traditional medicine. In our research program to explore novel functions of asana extract, we focused on its skin-whitening effect because asana has been used as a remedy for chronic skin diseases. In addition, the authors have already reported an improvement in blood fluidity that brightens dull facial skin. Based on these effects, asana is a promising candidate agent that possesses both blood fluidity and anti-tyrosinase activities. We focused on the anti-tyrosinase activity and anti-oxidative activities of asana and the results are summarized in this report. We found that a 50% ethanolic extract obtained from asana (PM-ext) showed 23%, 53%, and 71% inhibition against mushroom tyrosinase at 12.5, 50, and 200 µg/mL. Oxyresveratrol and isoliquiritigenin were identified as the active compounds by activity-guided purification. Oxyresveratrol has higher potency than isoliquiritigenin and the IC50 of oxyresveratrol was estimated to be 2.1 µM. On the other hand, isoliquiritigenin showed 21%, 28%, and 38% inhibition at 10, 50, and 100 µM, respectively. The inhibitory activity of oxyresveratrol was compared with 3 stilbenes, pterostilbene, resveratrol, and piceatannol. Although oxyresveratrol showed 72.8%, 81.0%, and 85.4% inhibition at 2, 5, and 10 µM, respectively, pterostilbene, resveratrol, and piceatannol showed no effects at the same concentration; these compounds also demonstrated anti-melanogenesis activity on B16 murine melanoma cells. As a result, oxyresveratrol showed the most potent activity, without cytotoxicity, with 38%, 74%, and 84% inhibition at 2, 10, and 20 µM, respectively, while pterostilbene showed 26%, 71%, and 79% inhibition at the same concentration with cytotoxicity at 10 and 20 µM. Resveratrol showed 20%, 41%, and 57% inhibition without cytotoxicity at 2, 10, and 20 µM, respectively. Auto-oxidation is one of the major factors in melanin biosynthesis and anti-oxidative activity is suitable for an anti-melanogenesis agent. We investigated the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical-scavenging activity by PM-ext. As a result, PM-ext showed 16%, 33%, and 73% DPPH radical-scavenging activity at 10, 20, and 50 µg/mL, respectively. Oxyresveratrol showed 19%, 31%, and 59% scavenging activity at 10, 20, and 50 µM, respectively, similar to piceatannol. In addition, PM-ext showed 29%, 48%, and 80% suppressive activity on AGEs production at 3.1, 12.5, and 50 µg/mL, respectively. Oxyresveratrol showed 32%, 47%, and 55% activity at 10, 50, and 100 µM, respectively, and this was the most potent among the stilbenes tested. These results suggest that PM-ext could be a promising candidate as skin-whitening agent.

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Inhibition of Advanced Glycation End Products Formation by Mangifera indica Leaf Extract

Cited by 8 publications

References 19 publications

Bio-guided identification of antiglycative constituents from the leaves of Mangifera indica L.

Bio-guided identification of antiglycative constituents from the leaves of Mangifera indica L.

In vitro Antioxidant Activity of Mangifera indica Leaf Extracts

Anti-tyrosinase and Anti-oxidative Activities by Asana: the Heartwood of Pterocarpusmarsupium

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