Inhibition of advanced glycation end products formation and inflammation in C. elegans: Studies of potential of Lyngbya sp. against expression of stress related genes and Live cell imaging

Kumar, Rai Sameer; Shakambari, Ganeshan; Ashokkumar, Balasubramaniem; Varalakshmi, Perumal

doi:10.1016/j.bcab.2018.11.020

Cited by 6 publications

(7 citation statements)

References 43 publications

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“…The marine cyanobacteria Lyngbya spp. are, to date the most productive source of bioactive cyanobacterial compounds [76] and show potent anti-oxidant, anti-inflammatory, anti-diabetic and anti-cancer activity [19,77]. In particular, lipopeptides isolated from the cyanobacterium Lyngbia majuscula have shown a spectrum of biological activities consistent with their functioning as defense metabolites, including sodium channel blocking activity and arthropod and fish toxicity [78,79].…”

Section: Cyanobacteriamentioning

confidence: 99%

Marine Organisms for the Sustainable Management of Plant Parasitic Nematodes

Veronico

Melillo

2021

Plants

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Plant parasitic nematodes are annually responsible for the loss of 10%–25% of worldwide crop production, most of which is attributable to root-knot nematodes (RKNs) that infest a wide range of agricultural crops throughout the world. Current nematode control tools are not enough to ensure the effective management of these parasites, mainly due to the severe restrictions imposed on the use of chemical pesticides. Therefore, it is important to discover new potential nematicidal sources that are suitable for the development of additional safe and effective control strategies. In the last few decades, there has been an explosion of information about the use of seaweeds as plant growth stimulants and potential nematicides. Novel bioactive compounds have been isolated from marine cyanobacteria and sponges in an effort to find their application outside marine ecosystems and in the discovery of new drugs. Their potential as antihelmintics could also be exploited to find applicability against plant parasitic nematodes. The present review focuses on the activity of marine organisms on RKNs and their potential application as safe nematicidal agents.

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Section: Cyanobacteriamentioning

confidence: 99%

Marine Organisms for the Sustainable Management of Plant Parasitic Nematodes

Veronico

Melillo

2021

Plants

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“…The cyanobacteria genus Lyngbya has been extensively studied regarding its antioxidant and anti-inflammatory potential. Ethanolic extract from strains of this genus demonstrated an antioxidant activity that exceeded the one from the standard ascorbic acid and a lower IC 50 value than the standard phloroglucinol (16.42 ± 0.28 µg/mL vs. 52.57 ± 0 µg/mL, respectively), in vitro [124]. These in vitro results were then confirmed in a hyperglycemic C. elegans model with live cell imaging by HCS and by the fluorescent quantification of advanced glycation end products (AGEs).…”

Section: Cyanobacteria Potential In Alzheimer Diseasementioning

confidence: 82%

“…AGEs formation in nematodes treated with the ethanolic extract showed a prominent decrease comparing with the non-treated [124]. In addition to the antioxidant studies, the anti-inflammatory activity was also studied through the nitric oxide (NO) radical scavenging assay and by exposing C. elegans TJ356 daf16 to Pseudomonas aeruginosa [124]. Results revealed a noticeable NO scavenging activity and prevention of the induced inflammatory response of the C. elegans treated with the ethanolic extract.…”

Section: Cyanobacteria Potential In Alzheimer Diseasementioning

confidence: 98%

“…These in vitro results were then confirmed in a hyperglycemic C. elegans model with live cell imaging by HCS and by the fluorescent quantification of advanced glycation end products (AGEs). AGEs formation in nematodes treated with the ethanolic extract showed a prominent decrease comparing with the non-treated [124]. In addition to the antioxidant studies, the anti-inflammatory activity was also studied through the nitric oxide (NO) radical scavenging assay and by exposing C. elegans TJ356 daf16 to Pseudomonas aeruginosa [124].…”

Section: Cyanobacteria Potential In Alzheimer Diseasementioning

confidence: 99%

“…Results revealed a noticeable NO scavenging activity and prevention of the induced inflammatory response of the C. elegans treated with the ethanolic extract. The fluorescence intensity of DAF-16 GFP expression was higher in worms treated with the ethanolic extract than in the no-treated worms [124]. Later, the daf-16 gene expression analysis evidenced that the ethanolic extract induces the daf-16 expression in inflammatory worms, which inhibits NF-kB activity and regulates the immune "T helper cells" activation [124].…”

Section: Cyanobacteria Potential In Alzheimer Diseasementioning

confidence: 99%

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Bridging Cyanobacteria to Neurodegenerative Diseases: A New Potential Source of Bioactive Compounds against Alzheimer’s Disease

et al. 2021

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Neurodegenerative diseases (NDs) represent a drawback in society given the ageing population. Dementias are the most prevalent NDs, with Alzheimer’s disease (AD) representing around 70% of all cases. The current pharmaceuticals for AD are symptomatic and with no effects on the progression of the disease. Thus, research on molecules with therapeutic relevance has become a major focus for the scientific community. Cyanobacteria are a group of photosynthetic prokaryotes rich in biomolecules with confirmed activity in pathologies such as cancer, and with feasible potential in NDs such as AD. In this review, we aimed to compile the research works focused in the anti-AD potential of cyanobacteria, namely regarding the inhibition of the enzyme β-secretase (BACE1) as a fundamental enzyme in the generation of β-amyloid (Aβ), the inhibition of the enzyme acetylcholinesterase (AChE) lead to an increase in the availability of the neurotransmitter acetylcholine in the synaptic cleft and the antioxidant and anti-inflammatory effects, as phenomena associated with neurodegeneration mechanisms.

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