Inhibition of aflatoxin B1 mutagenicity by cyclopiazonic acid in the presence of human liver preparations

Vilar, Monica Sabater; Kuilman-Wahls, Mariella E.M.; Fink‐Gremmels, Johanna

doi:10.1016/s0378-4274(03)00196-6

Cited by 12 publications

(3 citation statements)

References 42 publications

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“…The anti-carcinogenic and anti-mutagenic activities of beans are highly associated with the presence of phenolic compounds as well as other bioactive compounds [ 62 , 93 ]. Phenolic compounds have the potential to inhibit mutagenic agents including polycyclic aromatic hydrocarbons, nitrosamines, and mycotoxins by inhibiting activation enzymes, provoking detoxification enzymes and intonation of commencement of mutagens [ 172 , 173 ]. Furthermore, common beans possess anti-carcinogenic and anti-mutagenic properties due to their phenolic compounds interacting with ultimate toxicants or mutagens, scavenging activities of phenolics, and inhibition of metabolism of the ultimate mutagen [ 62 , 76 , 174 ].…”

Section: Health Promoting Effects Of Polyphenol-rich Dry Beansmentioning

confidence: 99%

Polyphenol-Rich Dry Common Beans (Phaseolus vulgaris L.) and Their Health Benefits

Ganesan

2017

IJMS

226

136

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Polyphenols are plant metabolites with potent anti-oxidant properties, which help to reduce the effects of oxidative stress-induced dreaded diseases. The evidence demonstrated that dietary polyphenols are of emerging increasing scientific interest due to their role in the prevention of degenerative diseases in humans. Possible health beneficial effects of polyphenols are based on the human consumption and their bioavailability. Common beans (Phaseolus vulgaris L.) are a greater source of polyphenolic compounds with numerous health promoting properties. Polyphenol-rich dry common beans have potential effects on human health, and possess anti-oxidant, anti-diabetic, anti-obesity, anti-inflammatory and anti-mutagenic and anti-carcinogenic properties. Based on the studies, the current comprehensive review aims to provide up-to-date information on the nutritional compositions and health-promoting effect of polyphenol-rich common beans, which help to explore their therapeutic values for future clinical studies. Investigation of common beans and their impacts on human health were obtained from various library databases and electronic searches (Science Direct PubMed, and Google Scholar).

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Section: Health Promoting Effects Of Polyphenol-rich Dry Beansmentioning

confidence: 99%

Polyphenol-Rich Dry Common Beans (Phaseolus vulgaris L.) and Their Health Benefits

Ganesan

2017

IJMS

226

136

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“…Although Friedman et al, (1997) documented the lack of toxicological interaction in rat hepatocytes culture subjected to combination of AFB1 and AFB2, the ovarian cancer cells and lung fibroblasts of human origin displayed additive effect while human umbilical vein endothelial cells exhibited synergistic effect upon coexposure to AFB1 and AFB2 (Braicu et al, 2010). Bacterial bioassays demonstrated enhanced genotoxic (Yates et al, 1987) and mutagenic (Vilar et al, 2003) effects of AFB1 resulting from the concomitant use of cyclopiazonic acid. Golli-Bennour et al ( 2010) suggested an additive effect following the co-exposure of Vero cells to AFB1 and ochratoxin A.…”

Section: F) Toxicological Interaction Of Afts With Other Mycotoxins I...mentioning

confidence: 99%

Aflatoxins Biosynthesis, Toxicity and Intervention Strategies: A Review

et al. 2018

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“…Experimental evidence suggests that phenolics can act by one or more mechanisms. One of these mechanisms is the modulation of metabolic activation of mutagens, by inhibiting activation enzymes [8][9][10], or by stimulating detoxification enzymes [11,12]. For example, several flavonoids have the capacity to suppress the mutagenic activity of AFB 1 when they are added at low concentrations to a rat liver microsomal activation system in the presence of Salmonella tester strains [12].…”

Section: Introductionmentioning

confidence: 99%

Relationship Among Antimutagenic, Antioxidant and Enzymatic Activities of Methanolic Extract from Common Beans (Phaseolus vulgaris L)

Cardador‐Martínez

Albores²,

Bah

et al. 2006

Plant Foods Hum Nutr

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Common beans are rich in phenolic compounds, which can provide health benefits to the consumer. The objective of this work was to study the relationship among antimutagenicity, antioxidant and enzymatic activities of methanolic extract and trolox by principal components multivariate analysis. Antimutagenicity of phenolic compounds present in methanolic extract from the seed coat of common beans (P. vulgaris, Flor de Mayo Bajío cultivar) and trolox against AFB1 mutagenicity were evaluated in the Salmonella typhimurium microsuspension assay. Antioxidant capacity of methanolic extract and trolox were evaluated using beta-carotene and 1,1-diphenyl-2-picryhydrazyl (DPPH) in vitro model assays. Cythrome P450 activity was measured by fluorometric assay. For phenolic extract, trolox and phenolic extract+trolox, the inhibition on AFB1 mutagenicity in tester strain TA100 was 47, 59 and 69%, respectively. While in TA98 was 39, 48 and 68%. The inhibition of phenolic compounds, trolox and phenolic compounds+trolox on cytochrome P450 (CYP450) activity was 48, 59 and 88%, respectively. Correlation analysis showed that phenolic extract and trolox have high antimutagenic and antioxidant activity and also inhibited enzymatic activity. The results suggest that the primary mechanism of action of phenolic compounds in beans against AFB1 mutagenicity may be extra-cellular in the microsuspension assay.

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Inhibition of aflatoxin B1 mutagenicity by cyclopiazonic acid in the presence of human liver preparations

Cited by 12 publications

References 42 publications

Polyphenol-Rich Dry Common Beans (Phaseolus vulgaris L.) and Their Health Benefits

Polyphenol-Rich Dry Common Beans (Phaseolus vulgaris L.) and Their Health Benefits

Aflatoxins Biosynthesis, Toxicity and Intervention Strategies: A Review

Relationship Among Antimutagenic, Antioxidant and Enzymatic Activities of Methanolic Extract from Common Beans (Phaseolus vulgaris L)

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