Inhibition of aldosterone production by testosterone in male rats

Kau, Mei Mei; Lo, Ming Jae; Wang, Shyi Wu; Tsai, Shau‐Wei; Chen, Jiann Jong; Chiao, Yu Chung; Yeh, Jiun Yih; H, Lin; Shum, Andrew Yau Chik; Fang, Victor S.; Ho, Low Tone; Wang, Paulus S.

doi:10.1016/s0026-0495(99)90123-3

Cited by 51 publications

(31 citation statements)

References 28 publications

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“…In addition, our results reveal a marked sexual dimorphism in the adrenal glands of CD1 mice, affecting not only the weight and size of the gland but also the secretion of corticosterone and aldosterone, steroid hormones that are regulated mainly by ACTH secretion and by the renin-angiotensin system and plasma potassium concentration, respectively (16,34,51). This sexdependent dimorphism in the murine adrenals, with corticosterone and aldosterone values higher in females than in males, is in agreement what that found in rats and humans (1,23,25,27,30,45,56). This finding could be related to the higher mRNA levels of CYP21 (21-hydroxylase) and CYP11B2 (aldosterone synthase) found in the female adrenal, since these two enzymes regulate the last steroidogenic steps in the mouse adrenal gland (12).…”

Section: Discussionsupporting

confidence: 90%

Sexual dimorphism of ornithine decarboxylase in the mouse adrenal: influence of polyamine deprivation on catecholamine and corticoid levels

Bastida¹,

Cremades²,

Castells³

et al. 2007

American Journal of Physiology-Endocrinology and Metabolism

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Bastida CM, Cremades A, Castells MT, López-Contreras AJ, López-García C, Sánchez-Mas J, Peñ afiel R. Sexual dimorphism of ornithine decarboxylase in the mouse adrenal: influence of polyamine deprivation on catecholamine and corticoid levels. Am J Physiol Endocrinol Metab 292: E1010 -E1017, 2007. First published December 5, 2006; doi:10.1152/ajpendo.00316.2006.-Adrenal sexual dimorphism is thought to be important in explaining sex-related differences regarding prevalent diseases and the responses to stress and drugs. We report here that in CD1 mice there is marked sexual dimorphism affecting not only gland size and corticoid hormone secretion but also adrenal ornithine decarboxylase (ODC), polyamine, and catecholamine levels in which testosterone appears to be a major determinant. Our results show that adrenal weight, ODC activity, and corticosterone and aldosterone secretion were higher in female than in male mice and that orchidectomy brought these male parameters closer to the values found in females. mRNA levels of steroidogenic proteins SF-1, Dax-1, steroid 21-hydroxylase, and aldosterone synthase appeared to be slightly higher in female than in male adrenals. Immunocytochemical analysis of adrenal ODC revealed that immunoreactivity was higher in females than in males and was located mainly in the cortical cells, and especially in zona glomerulosa, whereas no sex differences in ODC mRNA levels were observed. These results suggest that sex-associated differences in the expression of ODC in the mouse adrenal gland appear to be related mainly to posttranscriptional mechanisms. Combination treatment of mice with ␣-difluoromethylornithine (a suicide inhibitor of ODC) and a polyamine-deficient diet produced a marked decrease in adrenal polyamine and catecholamine levels and a significant reduction in plasma corticosterone and aldosterone concentrations that were not associated with a decrease in the mRNA levels of steroidogenic proteins. All of these data suggest a relevant role for testosterone, ODC, and polyamines in the mouse adrenal function. mice; ␣-difluoromethylornithine; corticosterone; aldosterone; steroidogenesis THE ADRENAL GLAND plays an important role in stress response, with the hypothalamic-pituitary-adrenal axis and the sympatho-adrenomedulary system as the principal components (41). Considerable evidence has accumulated indicating that gonadal factors act as regulators of the hypothalamic-pituitary-adrenal axis and adrenal function. In the rat there is a marked sexual dimorphism in adrenal weight, plasma ACTH, and corticosterone concentrations, with females having higher values than males (1,25,27,30,45). This adrenal sexual dimorphism is thought to be an important factor in explaining sex differences in relation to prevalent diseases associated with hypothalamic-pituitary-adrenal axis reactivity, such as cardiovascular disease, inflammation, diabetes, and hypertension (19,55). On the other hand, it has been suggested that a transient increase in ornithine decarboxylase (ODC) activity and tissue p...

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Section: Discussionsupporting

confidence: 90%

Sexual dimorphism of ornithine decarboxylase in the mouse adrenal: influence of polyamine deprivation on catecholamine and corticoid levels

Bastida¹,

Cremades²,

Castells³

et al. 2007

American Journal of Physiology-Endocrinology and Metabolism

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“…There is evidence to suggest that this may be the case, since Miller and colleagues 90 found higher blood pressure and aldosterone levels in men than in women, and Schunkert et al 91 found a positive correlation between dehydroepiandrosterone sulfate (a metabolite of testosterone), aldosterone levels, and blood pressure in a population of hypertensive men. However, Kau and colleagues 92 reported that testosterone replacement in castrated male rats decreased corticotropin-stimulated aldosterone release.…”

Section: Other Mechanism(s) By Which Androgens May Influence Blood Prmentioning

confidence: 99%

Gender Differences in the Regulation of Blood Pressure

2001

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Abstract-Men are at greater risk for cardiovascular and renal disease than are age-matched, premenopausal women.Recent studies using the technique of 24-hour ambulatory blood pressure monitoring have shown that blood pressure is higher in men than in women at similar ages. After menopause, however, blood pressure increases in women to levels even higher than in men. Hormone replacement therapy in most cases does not significantly reduce blood pressure in postmenopausal women, suggesting that the loss of estrogens may not be the only component involved in the higher blood pressure in women after menopause. In contrast, androgens may decrease only slightly, if at all, in postmenopausal women. In this review the possible mechanisms by which androgens may increase blood pressure are discussed. Findings in animal studies show that there is a blunting of the pressure-natriuresis relationship in male spontaneously hypertensive rats and in ovariectomized female spontaneously hypertensive rats treated chronically with testosterone. The key factor in controlling the pressure-natriuresis relationship is the renin-angiotensin system (RAS). The possibility that androgens increase blood pressure via the RAS is explored, and the possibility that the RAS also promotes oxidative stress leading to production of vasoconstrictor substances and reduction in nitric oxide availability is proposed. Key Words: sex characteristics Ⅲ hypertension Ⅲ angiotensin II Ⅲ nitric oxide Ⅲ oxidative stress I n this review gender differences in blood pressure control are explored, including possible mechanisms by which androgens may increase blood pressure. Gender Differences in Blood Pressure Regulation in HumansMen are generally at greater risk for cardiovascular and renal disease than are age-matched, premenopausal women. Recent studies using the technique of 24-hour ambulatory blood pressure monitoring have shown that blood pressure is higher in men than in women at similar ages. As shown in Figure 1, Wiinber and colleagues 1 studied 352 normotensive (for age) Danish men and women, aged 20 to 79 years, and found that blood pressure increased with aging in both men and women, but that men had higher 24-hour mean blood pressure, by approximately 6 to 10 mm Hg, than did women, until the age of 70 to 79 years, when blood pressure was similar for men and women. Khoury and colleagues 2 performed ambulatory blood pressure monitoring on 131 men and women, aged 50 to 60 years, and found that men had higher blood pressure than did women. Findings were similar in a meta-analysis study performed by Staessen et al. 3 In addition, the Third National Health and Nutrition Evaluation Survey (NHANES III) showed that, in general, men had higher blood pressure than women through middle age. 4 Furthermore, the incidence of uncontrolled hypertension is also greater in men than in women. 5After menopause, however, blood pressure increases in women as well. The data from NHANES III, shown in Figure 2, confirmed that by 60 to 69 years of age, non-Hispanic black and Hi...

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“…Эти результаты дают основание пола-гать, что снижение уровня альдостерона непосред-ственно связано с действием Т. Имеются единичные экспериментальные исследования, свидетельствую-щие о наличии функциональной взаимосвязи меж-ду альдостероном и Т [21,22]. В частности, показа-но, что Т посредством подавления активности син-тетазы альдостерона снижает базальную и стимули-руемую ангиотензинном II секрецию альдостерона [23,24].…”

Section: Discussionunclassified

The age-specific peculiarities of hormonal and metabolic imbalance in the young and adult men with obesity

Гончаров

Katsiya

Кация³

et al. 2015

Probl Endokrinol (Mosk)

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The objective of the present study was to elucidate the peculiar features of hormonal and metabolic imbalance in the young and adult men depending on the time of obesity manifestation, that is in adolescence or in the mature age. It was shown that over 40% of the young and adult men with obesity developed the well-apparent testosterone deficiency regardless of the time of obesity manifestation (Me 11.2-11.7 nmol/l). The overwhelming majority of the patients showing testosterone deficiency (60-80%) made up subgroups with metabolic syndrome (MS). The young and adult men in whom obesity began to develop in adolescence exhibited a more pronounced increase of fasting blood insulin level and HOMA-IR index than the men who developed obesity in the adulthood. Only in both young and adult men who began to develop obesity in adolescence, the blood aldosterone and cortisol levels were higher than in the age-matched normal subjects. These men, unlike those with obesity starting to develop in the adulthood, had the blood aldosterone and cortisol levels shifted to the upper limit of the reference values

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Inhibition of aldosterone production by testosterone in male rats

Cited by 51 publications

References 28 publications

Sexual dimorphism of ornithine decarboxylase in the mouse adrenal: influence of polyamine deprivation on catecholamine and corticoid levels

Sexual dimorphism of ornithine decarboxylase in the mouse adrenal: influence of polyamine deprivation on catecholamine and corticoid levels

Gender Differences in the Regulation of Blood Pressure

The age-specific peculiarities of hormonal and metabolic imbalance in the young and adult men with obesity

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