Inhibition of alpha-glucosidase enzyme and antioxidant activity of the metabolites purified from an endophytic fungus of Simarouba glauca DC.

Mugaranja, Kirana P.; Kulal, Ananda

doi:10.1016/j.sajb.2022.05.045

Cited by 5 publications

(2 citation statements)

References 67 publications

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“…[17][18][19] Although synthetic enzyme inhibitors (acarbose, miglitol, metformin and voglibose) used today can control hyperglycemia, they cause gastrointestinal side effects such as diarrhea, gas and abdominal bloating. 11,20 Based on these reasons, plants that contain molecules with the potential to inhibit enzymes are mainly used for studying inhibitors of ⊍-amylase, ⊍-glucosidase, and tyrosinase with minimal or no side effects. 21,22 Modern medicine and pharmacy rely heavily on the research of biomolecule activities and mechanisms of action, which forms the foundation for the creation of novel chemically synthesized medications.…”

Section: Introductionmentioning

confidence: 99%

“…The activity of α‐glucosidase and α‐amylase can have a significant impact on blood sugar levels, and inhibiting their activity is a strategy used to manage conditions such as diabetes 17‐19 . Although synthetic enzyme inhibitors (acarbose, miglitol, metformin and voglibose) used today can control hyperglycemia, they cause gastrointestinal side effects such as diarrhea, gas and abdominal bloating 11,20 . Based on these reasons, plants that contain molecules with the potential to inhibit enzymes are mainly used for studying inhibitors of α‐amylase, α‐glucosidase, and tyrosinase with minimal or no side effects 21,22 .…”

Section: Introductionmentioning

confidence: 99%

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Phytochemical analyses by LC‐HRMS, FTIR spectral analysis, antioxidant, antidiabetic and antityrosinase activity of Crataegus orientalis Pall. ex M. Bieb fruit extracted with various solvents

Cakmak

2024

J Sci Food Agric

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BACKGROUNDCrataegus orientalis Pall. ex M. Bieb fruit (COPMB) is extensively used as a source of various products in the medicinal‐aromatic field and holds the potential for erosion control, ornamental purposes, food source, and economic benefits for forest villagers from its fruits. This study aims to determine the chemical components and biological activities of extracts prepared from COPMB using different solvents.RESULTSThe present work was designed to define the antioxidant activity [phosphomolybdenum (total antioxidant capacity), 2,2′‐azino‐bis(3‐ethylbenzothiazoline‐6‐sulfonic acid) (ABTS), ferric reducing antioxidant power (FRAP), cupric ion‐reducing antioxidant capacity (CUPRAC) and metal chelating activity (MCA)], phytochemical screening analysis, enzyme inhibitor (α‐amylase, α‐glucosidase and tyrosinase) potential, and liquid chromatography‐high resolution mass spectrometry (LC‐HRMS) secondary metabolite profiling in different extracts of COPMB. The results of LC‐HRMS revealed that fumaric acid was the main phenolic compound in all extracts. Among the extracts, ethyl acetate extract has the highest phytochemical and antioxidant properties [total phenolic content (TPC): 32.5 mg GAE/g, total flavonoid content (TFC): 12.2 mg QE/g, ABTS: 213.0 mg TE/g; CUPRAC: 126.0 mg TE/g, MCA: 145.0 mg EDTA/g; FRAP: 122.8 mg TE/g; TAC: 2.8 mmol TE/g]. Ethyl acetate and methanol extracts are more effective in α‐amylase (0.27 ± 0.01 mg/mL; 0.12 ± 0.00 mg/mL), α‐glucosidase (0.63 ± 0.02 mg/mL; 0.77 ± 0.02 mg/mL) and tyrosinase (0.03 ± 0.00 mg/mL; 0.03 ± 0.00 mg/mL) enzyme inhibition potentials compared to standard acarbose (0.75 ± 0.02 mg/mL for α‐amylase; 1.11 ± 0.03 mg/mL for α‐glucosidase) and kojic acid (0.04 ± 0.00 mg/mL).CONCLUSIONThe findings from this study suggest that COPMB could serve as a valuable source of natural agents for the food and pharmaceutical industry. © 2024 Society of Chemical Industry.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Phytochemical analyses by LC‐HRMS, FTIR spectral analysis, antioxidant, antidiabetic and antityrosinase activity of Crataegus orientalis Pall. ex M. Bieb fruit extracted with various solvents

Cakmak

2024

J Sci Food Agric

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Antioxidant, Enzyme and Molecular Docking Tyrosinase Inhibitory Activities of Major Polyphenols in Boscia coriacea Graells, Grewia erythraea (Schweinf.) Chiov., Ochradenus baccatus Delile, and Orthosiphon pallidus Royle Ex Benth.

Elmi,

Zengin,

Said

et al. 2024

Chemistry & Biodiversity

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Boscia coriacea Graells (BC), Grewia erythraea (Schweinf.) Chiov. (GE), Ochradenus baccatus Delile(OB), and Orthosiphon pallidus Royle ex Benth. (OP) are medicinal plants used in Djibouti. They were evaluated to determine their total phenolic content (TPC), flavonoid content (TFC), and phytochemical profile using HPLC‐MS/MS. Additionally, their antioxidant capacity was assessed through five various methods. Enzymatic activities were also measured, focusing on acetylcholinesterase (AChE), butyrylcholinesterase (BChE), α‐amylase, α‐glucosidase, and tyrosinase. OP extract had the highest TPC and exhibited the best antioxidant capacity, while OB and BC extracts had the highest TFC. Twenty‐seven compounds were identified and quantified by LCMS. GE extract demonstrated the highest AChE activity, while OP extract had the highest BChE activity. BC was most active against α‐amylase and α‐glucosidase, and only GE and OP extracts showed tyrosinase inhibition Invitro. In silico analysis, the compounds were optimized and docked to the human tyrosinase‐related protein 1 using AutoDock Vina, with ADME to evaluate their suitability based on key therapeutic criteria. Chlorogenic, neochlorogenic, gallic acids and quercetin emerged as promising tyrosinase inhibitors. These plants can be a viable source in the prevention and treatment related to tyrosinase enzyme inhibition.

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Secondary metabolites from the endophytic fungus Cladosporium sp. ZLM-6

Zhang,

Zheng,

Chu

et al. 2023

Biochemical Systematics and Ecology

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Inhibition of alpha-glucosidase enzyme and antioxidant activity of the metabolites purified from an endophytic fungus of Simarouba glauca DC.

Cited by 5 publications

References 67 publications

Phytochemical analyses by LC‐HRMS, FTIR spectral analysis, antioxidant, antidiabetic and antityrosinase activity of Crataegus orientalis Pall. ex M. Bieb fruit extracted with various solvents

Phytochemical analyses by LC‐HRMS, FTIR spectral analysis, antioxidant, antidiabetic and antityrosinase activity of Crataegus orientalis Pall. ex M. Bieb fruit extracted with various solvents

Antioxidant, Enzyme and Molecular Docking Tyrosinase Inhibitory Activities of Major Polyphenols in Boscia coriacea Graells, Grewia erythraea (Schweinf.) Chiov., Ochradenus baccatus Delile, and Orthosiphon pallidus Royle Ex Benth.

Secondary metabolites from the endophytic fungus Cladosporium sp. ZLM-6

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