Inhibition of Angiogenesis by Salmosin Expressed In Vitro

Kim, Soo In; Kim, Keun Sik; Kim, Hong Sung; Choi, Myoung Min; Kim, Doo Sik; Chung, Kyeong Woo; Park, Yong Serk

doi:10.3727/000000003772505353

Cited by 12 publications

(10 citation statements)

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“…The blocking of αvβ3 integrin in tumor cells inhibited their adhesion to the extracellular matrix and significantly reduced their motility, subsequently inhibiting metastasis. This effect was noted for monomeric medium-sized disintegrins, such as salmosin [69] and triflavin [68] and the homodimeric disintegrin, contortrostatin [73]. These drugs may be considered as alternatives to the humanized monoclonal antibodies used in cancer therapy.…”

Section: Platelet Aggregation Inhibitorsmentioning

confidence: 90%

“…These disintegrins are useful tools to decipher the mechanisms that occur during αvβ3-dependent angiogenesis. Monomeric RGD-disintegrins, accutin [67], triflavin [68], salmosin [69], rhodostomin [70,71], and the homodimeric RGD-disintegrin, contortrostatin [72], inhibit angiogenesis by binding to endothelial cells via αvβ3. It has been suggested that the binding of disintegrins to endothelial cells inhibits Review Article 3037 their motility and proliferation, possibly by induction of apoptosis in endothelial cells.…”

Section: Platelet Aggregation Inhibitorsmentioning

confidence: 99%

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Snake venom components and their applications in biomedicine

Koh

Armugam

Jeyaseelan

2006

Cell. Mol. Life Sci.

304

178

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Snake envenomation is a socio-medical problem of considerable magnitude. About 2.5 million people are bitten by snakes annually, more than 100,000 fatally. However, although bites can be deadly, snake venom is a natural biological resource that contains several components of potential therapeutic value. Venom has been used in the treatment of a variety of pathophysiological conditions in Ayurveda, homeopathy and folk medicine. With the advent of biotechnology, the efficacy of such treatments has been substantiated by purifying components of venom and delineating their therapeutic properties. This review will focus on certain snake venom components and their applications in health and disease.

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Section: Platelet Aggregation Inhibitorsmentioning

confidence: 90%

Section: Platelet Aggregation Inhibitorsmentioning

confidence: 99%

Snake venom components and their applications in biomedicine

Koh

Armugam

Jeyaseelan

2006

Cell. Mol. Life Sci.

304

178

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“…Hasta el momento estas proteínas aisladas de venenos de serpiente se han considerado herramientas útiles que han ayudado a descifrar los mecanismos de la angiogénesis dependiente αvβ3; las desintegrinas como accutina [65], triflavina [66], salmosina [67], rhodostamina [68,69] y contortrostatina [70] inhiben el proceso mencionado al unirse a las cé-lulas endoteliales vía αvβ3. En consecuencia, se ha sugerido que la unión de las desintegrinas a tales células inhibe su movilidad y proliferación.…”

Section: Toxinas Provenientes De Venenos De Serpiente Como Agentes Counclassified

Toxinas provenientes de venenos de serpiente: blancos terapéuticos, herramientas en investigación biomédica y agentes con potencial terapéutico

2014

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“…Kim et al, who had previously successfully generated a recombinant version of the disintegrin salmosin, developed an innovative approach to disintegrin delivery in a biological system [82]. The gene encoding this recombinant disintegrin was encapsulated into cationic liposomes [83].…”

Section: Disintegrins As Molecular Weaponsmentioning

confidence: 99%

Anti-Angiogenesis and RGD-Containing Snake Venom Disintegrins

Swenson¹,

Ramu²,

Markland³

2007

CPD

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Angiogenesis is the fundamental process by which new blood vessels are formed. Extensive research has shown that this event can be co-opted by tumors to ensure their growth, survival and metastasis. The study of tumor angiogenesis therefore represents a promising area of research for development of anti-cancer therapeutics. Integrins, a family of cell surface molecules, are a major target of interest as they are known to play a vital role in pathological angiogenesis. Remarkably, small disulfide-rich peptides known as disintegrins, isolated from the venoms of various snake species have been found to bind integrins with extremely high affinity and block their function. Disintegrins are capable of inhibiting several aspects of tumor cell behavior both in vitro and in vivo, including adhesion, migration, invasion, metastasis and angiogenesis. In this review, we will briefly discuss tumor angiogenesis and molecules implicated in the angiogenic process, with a special focus on the role of integrins. We will also discuss therapeutic approaches towards the treatment of tumor angiogenesis, including non-integrin-targeted agents currently in clinical trials. We will summarize the major findings from studies using disintegrins to target integrin-associated angiogenesis in cancer models. Finally, we will present results obtained in our laboratory using the novel dimeric disintegrin, contortrostatin (CN), in studies of endothelial cells and models of breast, ovarian and prostate cancer. In summary, disintegrins represent an exciting new class of molecules that can potentially be used in a clinical setting to inhibit angiogenesis and augment conventional chemotherapeutic agents in the treatment of cancer.

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Inhibition of Angiogenesis by Salmosin Expressed In Vitro

Cited by 12 publications

References 0 publications

Snake venom components and their applications in biomedicine

Snake venom components and their applications in biomedicine

Toxinas provenientes de venenos de serpiente: blancos terapéuticos, herramientas en investigación biomédica y agentes con potencial terapéutico

Anti-Angiogenesis and RGD-Containing Snake Venom Disintegrins

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