Inhibition of aspirin absorption by activated charcoal and apomorphine

Decker, Walter J.; Shpall, Robert A.; Corby, Donald G.; Combs, Harold F.; Payne, Carl E.

doi:10.1002/cpt1969105710

Cited by 76 publications

(8 citation statements)

References 2 publications

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“…Contrary to prevailing views, 3 • 13 aspirin adsorption on AC is partly reversible in vivo. When aspirin was equilibrated in water with sufficient AC to adsorb either 50 per cent or more than 99 per cent of the drug and these mixtures were administered orally, 87.4 per cent and 60.6 per cent, respectively, of the total aspirin dose was recovered in the urine.…”

Section: Discussioncontrasting

confidence: 75%

Effect of activated charcoal on aspirin absorption in man Part I

Levy

Tsuchiya

1972

Clin Pharma and Therapeutics

124

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Section: Discussioncontrasting

confidence: 75%

Effect of activated charcoal on aspirin absorption in man Part I

Levy

Tsuchiya

1972

Clin Pharma and Therapeutics

124

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“…The in vivo efficacy of activated charcoal in reducing the absorption of aspirin from therapeutic doses has been shown previously (Decker, Corby & Ibanez, 1968;Decker, Shpall, Corby, Combs & Payne, 1969;Chin, Picchioni & Duplisse, 1969;Atkinson & Azarnoff, 1971; and was confirmed by us. The reduction in peak plasma concentrations and availability was not as great as has been observed for other drugs (Crome, Dawling, Braithwaite, Masters & Walkey, 1977) because soluble aspirin is absorbed relatively rapidly.…”

Section: Methodssupporting

confidence: 75%

In Vitro and In Vivo Evaluation of Two Preparations of Activated Charcoal as Adsorbents of Aspirin

et al. 1983

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1 The adsorptive capacities of two preparations of activated charcoal have been studied both in vitro and in vivo using aspirin as a test compound. 2 The in vitro adsorptive capacities of the charcoal preparations were 477 mg of acetylsalicylic acid/g effervescent charcoal ('Medicoal'); 359 mg/g untreated standard charcoal ('Norit-A') and 482 mg/g reheated charcoal ('Norit A'). 3 In vivo both charcoal preparations significantly reduced peak salicylate concentrations and salicylate availability, to a similar extent (analysis of variance P < 0.001). 4 Both charcoal preparations have similar capacities for adsorbing aspirin both in vitro and in vivo.

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“…470 When 30g of activated charcoal was taken orally by healthy volunteers 30 minutes after the ingestion of 3g aspirin, the serum salicylate concentrations were only 50% of those of a control group. Vomiting induced by apomorphine had a similar effect (Decker .et al, 1969). Levy and Tsuchiya (1972) showed in volunteers that the effect of activated charcoal on the absorption of aspirin increased with increasing doses and decreased in the presence of food.…”

Section: Aspirinmentioning

confidence: 84%

“…Decker et al (1969) gave to volunteers in a crossover study either 30g of activated charcoal, apomorphine or both charcoal and apomor- Hours after admission Fig. 6.…”

Section: Effect Of Activated Charcoal Versus Emetics and Gastric Lavamentioning

confidence: 99%

Clinical Pharmacokinetics of Oral Activated Charcoal in Acute Intoxications

Neuvonen

1982

Clinical Pharmacokinetics

152

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Activated charcoal has the ability to adsorb a wide variety of substances onto its sUrface. This property can be applied in preventing the absorption of various drugs and toxins from the gastrointestinal tract and in some cases to increase their rate of elimination. In vitro. the extent of adsorption depends mainly on the relative amounts oj the charcoal and the drug ingested. but the quality and formulation of the activated charcoal. as well as other Jactors such as the pH of the incubation medium also have an effect. Under optimum conditions the adsorption to charcoal is a rapid process but desorption from charcoal is possible due. for example. to competition by other substances or to changes in pH.In acute poisonings the most important determinants of the efficacy oj activated charcoal are the delay in the administration and the amount of activated charcoal given. Activated charcoal should be given as a water suspension as soon as possible. preferably within 30 minutes oJthe ingestion of the toxic agent. However. in acute intoxications the absorption of drugs may be considerably delayed and thus charcoal may be effective when administered 24 hours after drug ingestion. At a constant charcoal-drug ratio. the adsorption capacity oj charcoal increases with increasing doses because the competitive effect of gastrointestinal contents diminishes. Thus the amount oj charcoal should be as high as feasible. i.e. about 50 to lOOg in adults. This amount is able to adsorb lethal doses of many drugs. Significant desorption from charcoal and subsequent systemic absorption of a drug is possible if inadequate amounts of charcoal are used. The adsorption to charcoal is more complete in poisonings with potent drugs. i.e. where the charcoal-drug ratio is high (e.g. digitalis glycosides. tricyclic antidepressants. etc.). With some drugs the adsorption capacity may be exceeded, e.g. in aspirin poisonings, but even in these cases the charcoal may adsorb that fraction oj the drug which is dissolved in the gastrointestinal./luids.In experimental studies. the efficacy of charcoal in preventing systemic absorption oj many drugs has been of the same order or even better than that of emesis, but in certain poisonings the efficacy oj charcoal is inadequate, e.g. in those caused by ethanol, methanol or iron salts. Charcoal is rather ineffective and may even be contraindicated in poisonings caused by caustic alkalis or acids. Charcoal is non-toxic but, if administered too rapidly, patients may vomit.Some drugs and toxic agents have a long elimination half-life and are excreted into the gastrointestinal tract and then reabsorbed. With such agents multiple oral doses of activated charcoal, e.g. 20g every 6 hours Jor 1 or 2 days, can accelerate their elimination and shorten the duration of intoxication.

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Inhibition of aspirin absorption by activated charcoal and apomorphine

Cited by 76 publications

References 2 publications

Effect of activated charcoal on aspirin absorption in man Part I

Effect of activated charcoal on aspirin absorption in man Part I

In Vitro and In Vivo Evaluation of Two Preparations of Activated Charcoal as Adsorbents of Aspirin

Clinical Pharmacokinetics of Oral Activated Charcoal in Acute Intoxications

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