Inhibition of ATF4-mediated elevation of both autophagy and AKT/mTOR was involved in antitumorigenic activity of curcumin

A review on the mechanisms underlying the antitumor effects of natural products by targeting the endoplasmic reticulum stress apoptosis pathway

“…Given the above background, the conclusions we have drawn also confirm that the ERS apoptotic pathway, the mitochondrial apoptotic pathway and autophagy most often function simultaneously, and that natural product-induced tumour cell death is mainly achieved through these combined pathways, and that related studies have focused on these three pathways. Regarding the link between the autophagic and apoptotic pathways, a study claimed that inhibition of ERSmediated autophagy in ATF4-associated cells could play an anticancer role (Yang et al, 2023). The results of this paper show that natural products promote ERS in order to promote apoptosis in tumour cells, and in the process ERS also mediates autophagy, which is primarily a protective pathway whose mechanism of action is to inhibit apoptosis by mitigating ERS and promoting the restoration of endoplasmic reticulum homeostasis.…”