Inhibition of Candida rugosa Lipase by Different Extracts of Five Algerian Plants and their Antioxidant Activities

Benguechoua, Madjda; Nia, Samira; Benarous, Khedidja; Khachba, Ihcen; Yousfi, Mohammed

doi:10.2174/1573408010666140812233628

Cited by 6 publications

(2 citation statements)

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“…Therefore, there is a great need of exploring plant derived metabolites as new potent and selective PL inhibitors. Medicinal plants have been the economical source of natural compounds with diverse biological activities (Benguechoua et al, 2014). Bioactive secondary metabolites such as flavonoids, terpenoids, tannins and alkaloids are promising PL inhibitors since they are present in relatively high concentrations in plant extracts (Birari and Bhutani, 2007;Shimura et al, 1992).…”

Section: Discussionmentioning

confidence: 99%

In vitro lipase inhibitory effect and kinetic properties of di-terpenoid fraction from Calotropis procera (Aiton)

Patil

Maheshwari

et al. 2015

Biocatalysis and Agricultural Biotechnology

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Section: Discussionmentioning

confidence: 99%

In vitro lipase inhibitory effect and kinetic properties of di-terpenoid fraction from Calotropis procera (Aiton)

Patil

Maheshwari

et al. 2015

Biocatalysis and Agricultural Biotechnology

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“…For instance, rosmarinic acid was reported as an A β aggregation inhibitor [ 103 , 104 ]. Besides, Benguechoua et al showed, for the first time, that an acetone/water extraction mixture with ethyl acetate and butanol fractions from Algerian T. algeriensis inhibited Candida rugosa lipase [ 105 ].…”

Section: In Vitro Pharmacological Propertiesmentioning

confidence: 99%

Unraveling the Phytochemistry, Traditional Uses, and Biological and Pharmacological Activities of Thymus algeriensis Boiss. & Reut

Mahdi

Bakrim

Bitchagno

et al. 2022

Oxidative Medicine and Cellular Longevity

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Growing concern for public health has increased the need to change the paradigm towards a healthcare system that advocates holistic practices while reducing adverse effects. Herbal therapy is becoming an integral part of the therapeutic arsenal, and several successful plant-derived compounds/molecules are being introduced into the market. The medicinal plants belonging to the genus Thymus are among the most important species within the Lamiaceae family. One of them is Thymus algeriensis which is mainly distributed in the Mediterranean region. For a long time, this species has been used in traditional medicine to treat several disorders and diseases including inflammation, diabetes, rheumatism, digestive, and respiratory affections. This review describes the traditional uses, phytochemical composition, and biological and pharmacological activities of T. algeriensis extracts. Data were obtained using electronic databases such as SciFindern, ScienceDirect, Scopus, and Web of Science. Several plant-based extracts and a broad spectrum of identified secondary metabolites were highlighted and discussed with respective activities and modes of action. T. algeriensis represents a promising natural resource for the pharmaceutical industry mainly for antioxidant, anti-inflammatory, antimicrobial, and anticancer activities. Considering these findings, more research is needed to transmute the conventional uses of T. algeriensis into scientifically sound information. Moreover, extensive preclinical, clinical, toxicological, and pharmacokinetic trials on this species and its derivatives compounds are required to underpin the mechanisms of action and ensure its biosafety and efficiency. This comprehensive review provides a scientific basis for future investigations on the use of T. algeriensis and derived compounds in health maintenance and promotion and disease prevention.

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In silico and in vitro Study of the Inhibitory Effect of Antiinflammatory Drug Betamethasone on Two Lipases

Nia

Benarous

Zahra

et al. 2020

AIAAMC

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Background: For the first time, the anti-inflammatory drugs: celecoxib, aspirin DL-lysine, niflumic acid, naproxen sodium, ibuprofen, and betamethasone are investigated for their inhibition activity against lipase. Objective: This work aims to demonstrate the inhibitory effect in vitro & in silico of six anti-inflammatory drugs on the enzymatic activity of two lipases. Method: In vitro study using p-nitrophenyllaurate as lipase substrate is used to determine inhibition potency. Molecular Docking is performed using the Autodock Vina for six drug molecules and two enzymes Candida rugosa lipase and human pancreatic lipase. Results: Bethametasone is the only one that represents an important inhibition effect with a value of IC50 of 0.36±0.01 mg/ml; while the other drugs represent values of IC50 > 2 mg/ml, signifying a very low inhibitory effect. Molecular docking allowed us to understand inhibitory – enzyme interactions and to confirm in vitro obtained results. Conclusion: These experiments showed that betamethasone can be used in the treatment of obesity and other diseases related to lipase activity.

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Inhibition of Candida rugosa Lipase by Different Extracts of Five Algerian Plants and their Antioxidant Activities

Cited by 6 publications

References 0 publications

In vitro lipase inhibitory effect and kinetic properties of di-terpenoid fraction from Calotropis procera (Aiton)

In vitro lipase inhibitory effect and kinetic properties of di-terpenoid fraction from Calotropis procera (Aiton)

Unraveling the Phytochemistry, Traditional Uses, and Biological and Pharmacological Activities of Thymus algeriensis Boiss. & Reut

In silico and in vitro Study of the Inhibitory Effect of Antiinflammatory Drug Betamethasone on Two Lipases

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