Inhibition of Carcinogenesis by minor Anutrient Constituents of the Diet

Wattenberg, Lee W.

doi:10.1079/pns19900022

Cited by 210 publications

(157 citation statements)

References 21 publications

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“…The average daily consumption of total glucosinolates in the UK was estimated to be about 50 mg (Wattenberg et al, 1986), whereas in the Netherlands, the estimated average intake of glucosinolates was 22 mg/day (Jongen, 1996;Kistenmaker et al, 1998). As compared with our average estimate of 6.5 mg, they are higher than what could be expected from the cruciferous vegetable consumption in these countries, two to three times higher than the intake reported in Spain.…”

Section: Discussionmentioning

confidence: 99%

Consumption of cruciferous vegetables and glucosinolates in a Spanish adult population

et al. 2007

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Objective: To assess the intake of glucosinolates and cruciferous vegetables among Spanish adults. Design: Cross-sectional analysis of a prospective cohort study. Setting: The Spanish cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC). Subjects: We analysed data from 40 684 men and women aged 35-64 years from the EPIC-Spain cohort. The usual diet was assessed by means of the dietary history method, and glucosinolate intake was calculated using a published food composition database. Results: The average intake of cruciferous vegetables was 11.3 g/day, accounting for about 5% of total vegetable consumption, whereas the daily intake of total glucosinolates was 6.5 mg, among which 35% were of indole type. The absolute intake of glucosinolates was in average higher in men than in women (6.8 vs 6.2 mg/day), whereas glucosinolate density per energy unit was higher in women's diet (3.4 vs 2.7 mg/4200 kJ). Northern regions consumed in average 36% more glucosinolates than Southern regions (7.3 vs 5.4 mg/day). There was a positive association of glucosinolate intake with body mass index, physical activity, educational level and an inverse relationship with alcohol consumption. Conclusions: Contrary to the pattern seen for total vegetable intake, our estimate of consumption of cruciferous vegetables, and hence of glucosinolates, is relatively low within Europe, which in turn is lower than in North America and several Asian populations.

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Section: Discussionmentioning

confidence: 99%

Consumption of cruciferous vegetables and glucosinolates in a Spanish adult population

et al. 2007

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“…The consumption of vegetables and fruits is known to reduce the risk of cancer (WATTENBERG, 1992). In general, the induction of phase 2 drug-metabolizing enzymes, the suppression of phase 1 enzymes, or the combination of these actions have been reported to be the mechanisms responsible for the protection against toxic and neoplastic effects of carcinogens (TALALAY, 1989;.…”

Section: Discussionmentioning

confidence: 99%

Effect of extracts from araticum (Annona crassiflora) on CCl4-induced liver damage in rats

Roesler¹

2011

Ciênc. Tecnol. Aliment.

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Section: Abstract: Deguelin; Aberrant Crypt Foci; Hexosaminidase; Cfmentioning

confidence: 99%

“…Identification of novel cancer-preventive agents has received considerable attention in the past 30 years. [3][4][5][6] Likewise, the development of surrogate end points or biomarkers that can be used for screening novel agents in experimental models has been extremely important to the field of chemoprevention.ACF have been identified on the colonic mucosal surface of rodents treated with carcinogens and shown to be one of the earliest recognizable lesions in the colon; furthermore, the carcinogens (e.g., AOM) that induce ACF also induce colon cancer in rodents. 7 Several lines of evidence strongly suggest that ACF are good intermediate biomarkers of colon cancer in both rodents 7 and humans.…”

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confidence: 99%

Deguelin suppresses the formation of carcinogen‐induced aberrant crypt foci in the colon of CF‐1 mice

Murillo

Kosmeder

Pezzuto

et al. 2003

Intl Journal of Cancer

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Deguelin [(7aS,BaS)-13,13a-dihydro-9,10-dimethoxy-3,3-dimethyl-3H-Bis[1]benzopyrano[3,4-b:6 ,5 -e]pyran-7(7aH)-one], a naturally occurring rotenone, has shown chemopreventive efficacy in several in vivo and in vitro models. In this report, the effectiveness of deguelin at inhibiting the development of AOM-induced colonic ACF was investigated in CF-1 mice. Loss of hex activity was assessed as a second biomarker. In an initial experiment, animals were given s.c. injections of AOM (10 mg/kg body weight) once a week for 2 weeks to induce ACF. Deguelin and vehicle (corn oil) were administered i.g. 7 days a week. Treatment was initiated 2 weeks prior to the first dose of carcinogen and continued for the duration of the study. The mean number of ACF for the control group was 29.0 ؎ 4.3, whereas the mean numbers of ACF in the deguelin groups were 24.8 ؎ 2.7, 7.2 ؎ 1.5 and 4.6 ؎ 1.4 at doses of 2.5, 5.0 and 10.0 mg/kg body weight, respectively. In a similar manner, treatment with deguelin significantly (p < 0.001) suppressed the appearance of hexcrypts in a dose-dependent manner. In a second study, the ability of deguelin to block the initiation and promotion stages of colon carcinogenesis was investigated. Greatest inhibition was observed when deguelin was administered during the promotional stage (73.3%, p < 0.001). These results demonstrate that deguelin is an efficacious chemopreventive agent against colon carcinogenesis. © 2002 Wiley-Liss, Inc. Key words: deguelin; aberrant crypt foci; hexosaminidase; CF-1 mice; colon; carcinogenesisColon cancer is the third most common cancer in the United States. It is estimated that 107,600 new cases of colon cancer will be diagnosed in 2002 and that 48,100 people will die from this disease. 1 In the past decade, many studies have helped to define the molecular mechanisms underlying this malignancy. 2 With a better understanding of the molecular pathogenesis of this disease, new strategies for its prevention and treatment continue to emerge. Identification of novel cancer-preventive agents has received considerable attention in the past 30 years. [3][4][5][6] Likewise, the development of surrogate end points or biomarkers that can be used for screening novel agents in experimental models has been extremely important to the field of chemoprevention.ACF have been identified on the colonic mucosal surface of rodents treated with carcinogens and shown to be one of the earliest recognizable lesions in the colon; furthermore, the carcinogens (e.g., AOM) that induce ACF also induce colon cancer in rodents. 7 Several lines of evidence strongly suggest that ACF are good intermediate biomarkers of colon cancer in both rodents 7 and humans. 8 Morphologically, ACF are distinguishable from normal crypts by their increased size and the more elliptical shape of the luminal opening, with a thicker lining of epithelial cells. 9 ACF contain elements of dysplasia (evident by alterations in enzyme activity) and express mutations in the APC gene and the ras oncogene, which suggests that they are part...

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Inhibition of Carcinogenesis by minor Anutrient Constituents of the Diet

Cited by 210 publications

References 21 publications

Consumption of cruciferous vegetables and glucosinolates in a Spanish adult population

Consumption of cruciferous vegetables and glucosinolates in a Spanish adult population

Effect of extracts from araticum (Annona crassiflora) on CCl4-induced liver damage in rats

Deguelin suppresses the formation of carcinogen‐induced aberrant crypt foci in the colon of CF‐1 mice

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