Inhibition of cholesterol absorption in rats by plant sterols.

Ikeda, Ikuo; Tanaka, Kazunari; Sugano, Michihiro; Vahouny, George V.; Gallo, Linda L.

doi:10.1016/s0022-2275(20)38403-0

Cited by 259 publications

(26 citation statements)

References 25 publications

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“…The tentatively identified compounds are known to possess several biological and pharmacological activities (Grover et al, 2002;Kumar et al, 2010;Hema et al, 2011). Several studies have shown that ß-Sitosterol, stigmasterol, betulin, ergost-8( 14)-en-3-ol, n-hexadecanoic acid, and palmitic acid have been found to have hypoglycemic effects by reducing the absorptions of cholesterol from the gut as shown in the Table 9 (Ikeda et al, 1988;Rajasekaran et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

Phytochemical Screening and Antidiabetic, Antihyperlipidemic, and Antioxidant Effects of Leptopus Cordifolius Decne. In Diabetic Mice

Rahman

Jan

et al. 2021

Front. Pharmacol.

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Plants are well known in traditional herbal medicines for their hypoglycemic and hypolipidemic activities and are often used due to their accessibility, affordability, and corollary effects. Leptopus cordifolius has been reported to control diabetes in folkloric medicine, but no known scientific research has been conducted to assess the plausibility of this assertion. Therefore, the current study is aimed to investigate the antidiabetic and hypolipidemic effects of Leptopus cordifolius leaves in alloxan-induced diabetic mice. The antidiabetic and antihyperlipidemic evaluation was conducted in Swiss albino mice at doses of 150–250°mg/kg for 15°days. The blood glucose, total cholesterol, triglyceride, LDL, HDL, creatinine, ALP, SGPT, and SGOT levels were estimated according to standard procedures. Phytochemicals of leaves were analyzed using GC-MS analysis. Enzymatic antioxidant activity of the plant was investigated spectrophotometrically by carrying out superoxide dismutase, peroxidase, and catalase assays. The membrane stabilization potential of L. cordifolius leaf extracts was carried out using an in vitro haemolytic assay. The results revealed a dose response effect with the methanolic extract of L. cordifolius which had significant antihyperglycemic effects at 150–250°mg/kg in alloxan treated mice, although less than the positive control (glibenclamide). Hyperlipidemic activity was significant at 250 mg/kg. The biochemical parameters, such as total cholesterol, triglyceride, LDL, HDL, creatinine, ALP, SGPT, and SGOT, were significantly improved (p < 0.01) by the methanolic extract of 250 mg/kg compared to the diabetic group. Treatment for 15 days showed significant elevation (p < 0.01) of antioxidant enzymes. GC-MS analysis provided tentative identifications of 52 compounds in the methanolic extract of L. cordifolius, of which 12 compounds have reported antidiabetic activity. In conclusion, methanolic extract of L. cordifolius of 150 and 250°mg/kg body weight showed significant antidiabetic and antihyperlipidemic activities in alloxan-induced diabetic mice and, with further work, has the potential to be used to manage blood glucose and cholesterol levels.

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Section: Discussionmentioning

confidence: 99%

Phytochemical Screening and Antidiabetic, Antihyperlipidemic, and Antioxidant Effects of Leptopus Cordifolius Decne. In Diabetic Mice

Rahman

Jan

et al. 2021

Front. Pharmacol.

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“…Its other properties can lead to gastric irritation, nausea and vomiting. Steroidal saponins also share in these properties but it is however associated with gastric lesions according to Ikeda, et al [35].…”

Section: Discussionmentioning

confidence: 99%

Untitled

2019

Journal of Diseases

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Contribution/Originality: This study has added to existing literature in ileum motility. The study uses a modified method used in the study. A new approach was originated by the use of kola nut. The investigation is new Logical analysis; ileum motility enhancement by kola nut. It offers a primary contribution on the positives and negatives of kola nut consumption. It documents the roles of kola nut in GIT. INTRODUCTIONCola nut also known as cola nitida is found mostly in Africa. The stimulant in cola nut is caffeine [1] which has the tendency to stimulate the nervous system, the heart and muscles [2]. It can also impact on acetylcholine and lead to the release of gastric hydrochloric acid; [3]. It is an evergreen tree plant with the leaves, flowers and bears fruits or seed within the pods which when ripe it will split to show the seeds. The seeds could be white, reddishgrey or brown. The seeds are edible but bitter. It is used as appetite suppressant, and for the treatment of migraine headache and indigestion [4]. The barks, seeds and leaves, are used in the treatment of dysentery, cough, vomiting and inflammation [5] .

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“…Most oils high in PUFA are naturally abundant in phytosterols, whereas MUFA-rich oils such as olive oil generally possess lower plant sterol concentrations. Research has demonstrated that cholesterol absorption efficiency varies inversely with the quantity of total phytosterols contained within an oil (14,16,17). Thus, the enhanced turnover and synthesis of cholesterol observed after PUFA feeding could be the result of diminished absorption subsequent to micellar exclusion of cholesterol by phytosterols (18).…”

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confidence: 99%

Phytosterols partially explain differences in cholesterol metabolism caused by corn or olive oil feeding

Howell

MacDougall

Jones

1998

Journal of Lipid Research

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To examine whether phytosterols in polyunsaturated oils account for their differential action on lipid metabolism compared with monounsaturated oils, 16 normolipidemic individuals consumed three 10-day experimental diets containing corn oil (high in polyunsaturated fatty acids and phytosterols), olive oil (high in monounsaturated fatty acids and low in phytosterols), or olive oil supplemented with phytosterols given at twice the level naturally found in corn oil (high in monounsaturated fatty acids and phytosterols). Plasma total cholesterol concentrations after both the olive oil and the olive oil-phytosterol treatments were higher ( P Ͻ 0.001) than those after the corn oil treatment. Olive oil treatment resulted in greater ( P Ͻ 0.05) plasma LDL-cholesterol and triglyceride concentrations compared to corn oil treatment. Addition of the phytosterol mixture to the olive oil diet resulted in suppression of the significant differences in LDLcholesterol and triglyceride concentrations between corn and olive oil. Free cholesterol fractional synthetic rates determined by deuterium incorporation were lower ( P Ͻ 0.05) with olive oil treatment compared to corn oil treatment; the significance of this difference was abolished with the addition of phytosterols to the olive oil diet.These results suggest that phytosterols are partly responsible for the differences in plasma cholesterol levels and synthesis observed between polyunsaturated and monounsaturated oils. -Howell, T. J., D. E. MacDougall, and P. J. H. Jones. Phytosterols partially explain differences in cholesterol metabolism caused by corn or olive oil feeding.

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Inhibition of cholesterol absorption in rats by plant sterols.

Cited by 259 publications

References 25 publications

Phytochemical Screening and Antidiabetic, Antihyperlipidemic, and Antioxidant Effects of Leptopus Cordifolius Decne. In Diabetic Mice

Phytochemical Screening and Antidiabetic, Antihyperlipidemic, and Antioxidant Effects of Leptopus Cordifolius Decne. In Diabetic Mice

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Phytosterols partially explain differences in cholesterol metabolism caused by corn or olive oil feeding

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