2007
DOI: 10.1016/j.bbrc.2007.04.098
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Inhibition of colon cancer growth and metastasis by NK4 gene repetitive delivery in mice

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Cited by 16 publications
(8 citation statements)
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“…Studies have documented that HGF stimulation or overexpression of the Met receptor can evoke metastatic properties in human and mouse CRC tumor-derived cell lines, including cell scattering, migration, and invasion in culture (13,28,29,32,56). Conversely, inhibition of Met receptor signaling in highly metastatic CRC cell lines through various approaches was shown to reduce their metastatic activities, namely blocking cell motility and invasiveness in vitro or reducing their capacity to form metastases in animal models (1,23,40,56,62,66). These studies performed within the context of established CRC-derived cell lines infer for a role of the Met/HGF receptor-signaling axis in CRC metastases.…”
Section: Discussionmentioning
confidence: 96%
“…Studies have documented that HGF stimulation or overexpression of the Met receptor can evoke metastatic properties in human and mouse CRC tumor-derived cell lines, including cell scattering, migration, and invasion in culture (13,28,29,32,56). Conversely, inhibition of Met receptor signaling in highly metastatic CRC cell lines through various approaches was shown to reduce their metastatic activities, namely blocking cell motility and invasiveness in vitro or reducing their capacity to form metastases in animal models (1,23,40,56,62,66). These studies performed within the context of established CRC-derived cell lines infer for a role of the Met/HGF receptor-signaling axis in CRC metastases.…”
Section: Discussionmentioning
confidence: 96%
“…Repeated administrations of NK4-containing plasmid DNA also inhibited the malignant behaviors of colon carcinoma (Wen et al, 2007). Actually, NK4 repetitive gene therapy potently inhibited the muscular invasion of MC-38 carcinoma cells.…”
Section: Inhibition Of Colon Cancer Metastasis By Nk4 Gene Deliverymentioning
confidence: 96%
“…Overall, the number of hepatic metastatic nodules was www.intechopen.com Endocrine Delivery System of NK4, an HGF-Antagonist and Anti-Angiogenic Regulator, for Inhibitions of Tumor Growth, Invasion and Metastasis 133 dramatically decreased by the repeated injections of NK4-cDNA containing plasmid. This study provides an anti-tumor model where NK4 is supplemented via a hydrpdynamicsbased gene therapy (Wen et al, 2007). Recently, hydrodynamic gene delivery using a rapid injection of a relatively large volume of DNA solution has facilitated experimental gene therapy studies, particularly in rodents (Suda et al, 2007).…”
Section: Inhibition Of Colon Cancer Metastasis By Nk4 Gene Deliverymentioning
confidence: 99%
“…For these reasons, HGF is considered to be a potentially valuable new therapeutic target for different tumors. Studies using NK4, a HGF antagonist, have shown an inhibitory effect on proliferation, invasion and angiogenesis in cell lines of gastric and pancreatic carcinoma, and of CRC (Hirao et al, 2002;Wen et al, 2007). In addition, anti-HGF monoclonal antibodies have been developed, thereby blocking binding to its receptor (Cao et al, 2001).…”
Section: Gfs Such As B-fgf Egf Tgf- As Well As Extracellular Matrmentioning
confidence: 99%