Inhibition of core fucosylation limits progression of diabetic kidney disease

Fang, Ming; Kang, Le; Wang, Xiaolang; Guo, Xiao; Wang, Weidong; Qin, Biaojie; Du, Xiangning; Tang, Qingzhu; Lin, Hongli

doi:10.1016/j.bbrc.2019.10.037

Cited by 11 publications

(8 citation statements)

References 24 publications

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“…Aberration of fucosylation, be it core or antennary has been implicated in our results just as stated in multiple chronic diseases 43 – 45 . For example, Herrera et al 46 identified core-fucosylated tetra-antennary glycan to be associated with poor breast cancer prognosis.…”

Section: Discussionsupporting

confidence: 67%

Multi-block data integration analysis for identifying and validating targeted N-glycans as biomarkers for type II diabetes mellitus

Adua

Afrifa-Yamoah

Peprah-Yamoah

et al. 2022

Sci Rep

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Plasma N-glycan profiles have been shown to be defective in type II diabetes Mellitus (T2DM) and holds a promise to discovering biomarkers. The study comprised 232 T2DM patients and 219 healthy individuals. N-glycans were analysed by high-performance liquid chromatography. The multivariate integrative framework, DIABLO was employed for the statistical analysis. N-glycan groups (GPs 34, 32, 26, 31, 36 and 30) were significantly expressed in T2DM in component 1 and GPs 38 and 20 were related to T2DM in component 2. Four clusters were observed based on the correlation of the expressive signatures of the 39 N-glycans across T2DM and controls. Cluster A, B, C and D had 16, 16, 4 and 3 N-glycans respectively, of which 11, 8, 1 and 1 were found to express differently between controls and T2DM in a univariate analysis $$(p < 0.05)$$ ( p < 0.05 ) . Multi-block analysis revealed that trigalactosylated (G3), triantennary (TRIA), high branching (HB) and trisialylated (S3) expressed significantly highly in T2DM than healthy controls. A bipartite relevance network revealed that HB, monogalactosylated (G1) and G3 were central in the network and observed more connections, highlighting their importance in discriminating between T2DM and healthy controls. Investigation of these N-glycans can enhance the understanding of T2DM.

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Section: Discussionsupporting

confidence: 67%

Multi-block data integration analysis for identifying and validating targeted N-glycans as biomarkers for type II diabetes mellitus

Adua

Afrifa-Yamoah

Peprah-Yamoah

et al. 2022

Sci Rep

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“…Aberration of fucosylation, be it core or antennary has been implicated in our results just as stated in multiple chronic diseases [41][42][43] . For example, Herrara et al, (2019) identified core-fucosylated tetra-antennary glycan to be associated with poor breast cancer prognosis 44 .…”

Section: Discussionsupporting

confidence: 67%

Multi-Block Data Integration Analysis for Identifying and Validating Targeted N-Glycans as Biomarkers for Type II Diabetes Mellitus

Adua

Yamoah

Peprah-Yamoah

et al. 2022

Preprint

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Plasma N-glycan profiles have been shown to be defective in type II diabetes Mellitus (T2DM) and holds a promise to discovering biomarkers. The study comprised 232 T2DM patients and 219 healthy individuals. N-glycans were analysed by high-performance liquid chromatography. Principal component analysis (PCA), discriminatory analysis and agglomerative hierarchical cluster analysis (HCA) were performed. N-glycan groups (GPs 34, 32, 26, 31, 36 and 30) were significantly expressed in T2DM in component 1 and GPs 38 and 20 were related to T2DM in component 2. Four clusters based on the correlation of the expressive signatures of the 39 N-glycans across T2DM and controls. Cluster A, B, C and D had 16, 16, 4 and 3 N-glycans respectively, of which 11, 8, 1 and 1 were found to express differently between controls and T2DM in a univariate analysis P. Multi-block analysis revealed that trigalactosylated (G3), triantennary (TRIA), high branching (HB) and trisialylated (S3) expressed significantly highly in T2DM than healthy controls. A bipartite relevance network revealed that HB, monogalactosylated (G1) and G3 were central in the network and observed more connections, highlighting their importance in discriminating between T2DM and healthy controls. Investigation of these N-glycans can enhance the understanding of T2DM.

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“…However, 7-6-1-0 and 7-7-1-0 showed lower expression in G5 when compared to G4. Studies have shown that altered fucosylated N-glycans were observed in serum samples from Type I diabetic patients, and that inhibition of fucosylation can reduce the progression of diabetic kidney disease [56,92]. The increase of 3-5-1-0 and 5-7-1-0 may play a role in obese and diabetic kidney disease progression.…”

Section: Comparison Between Obese and Diabetic Group And Control Groupmentioning

confidence: 99%

Changes in the Expression of Renal Brush Border Membrane N-Glycome in Model Rats with Chronic Kidney Diseases

Zhao

Yadav

et al. 2021

Biomolecules

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Chronic kidney disease (CKD) is defined by a reduced renal function i.e., glomerular filtration rate (GFR), and the presence of kidney damage is determined by measurement of proteinuria or albuminuria. Albuminuria increases with age and can result from glomerular and/or proximal tubule (PT) alterations. Brush-border membranes (BBMs) on PT cells play an important role in maintaining the stability of PT functions. The PT BBM, a highly dynamic, organized, specialized membrane, contains a variety of glycoproteins required for the functions of PT. Since protein glycosylation regulates many protein functions, the alteration of glycosylation due to the glycan changes has attracted more interests for a variety of disease studies recently. In this work, liquid chromatography-tandem mass spectrometry was utilized to analyze the abundances of permethylated glycans from rats under control to mild CKD, severe CKD, and diabetic conditions. The most significant differences were observed in sialylation level with the highest present in the severe CKD and diabetic groups. Moreover, high mannose N-glycans was enriched in the CKD BBMs. Characterization of all the BBM N-glycan changes supports that these changes are likely to impact the functional properties of the dynamic PT BBM. Further, these changes may lead to the potential discovery of glycan biomarkers for improved CKD diagnosis and new avenues for therapeutic treatments.

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Inhibition of core fucosylation limits progression of diabetic kidney disease

Cited by 11 publications

References 24 publications

Multi-block data integration analysis for identifying and validating targeted N-glycans as biomarkers for type II diabetes mellitus

Multi-block data integration analysis for identifying and validating targeted N-glycans as biomarkers for type II diabetes mellitus

Multi-Block Data Integration Analysis for Identifying and Validating Targeted N-Glycans as Biomarkers for Type II Diabetes Mellitus

Changes in the Expression of Renal Brush Border Membrane N-Glycome in Model Rats with Chronic Kidney Diseases

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