Inhibition of endogenous pancreatic enzyme secretion by oral pancreatic enzyme treatment

Abstract

Exogenous applied pancreatic enzymes, dose- and time-dependently inhibited endogenous pancreatic secretion. The obtained results strongly support the existence of a protease mediated feedback mechanism in humans.

Use of fecal elastase-1 to classify pancreatic status in patients with cystic fibrosis

“…There is some evidence that at least in the short term, exogenous pancreatic enzyme supplements lead to inhibition of endogenous pancreatic secretion. 19 A genetic predisposition to intermittent decreased secretion leading to sludging in the pancreatic ducts of PS patients with CF has been postulated as one cause of pancreatitis. 3 One can speculate that chronic pharmacologic inhibition of pancreatic secretion by exogenous pancreatic enzyme supplements could be additive and potentially transform a PS patient to one who is PI.…”

The impact of dietary fibres on the physiological processes governing small intestinal digestive processes

“…It is thought that dietary fibre interferes with the negative feedback regulation of pancreatic enzyme secretion leading to increased pancreatic exocrine function. Levels of pancreatic exocrine secretion have been evidenced to be regulated by intraluminal enzyme concentration through oral or duodenal addition of enzymes (Morisset, 2008;Walkowiak, Witmanowski, Strzykala, Bychowiec, Songin, Borski, et al, 2003). It was previously observed that participants fed a diet supplemented with 20g/day fibre for 4 weeks increased total postprandial pancreatic lipase output (Dukehart, Dutta, & Vaeth, 1989).…”

Assessment of exocrine pancreatic function in children and adolescents with direct and indirect testing

“…Alternatively, the increase in CCK and pancreatic fluid secretion into the intestine is inhibited by presence of trypsin in the intestine as well as other digestive enzymes ( 38 ). This feedback is accomplished via the CCK-releasing peptide in such that with the absence of peptides, CCK-releasing factor will be inactivated by trypsin and thus CCK secretion is decreased ( 28 ).…”