Inhibition of Endotoxin-Induced Uveitis by Methylprednisolone Acetate Nanosuspension in Rabbits

Adibkia, Khosro; Omidi, Yadollah; Siahi, M R; Javadzadeh, Alireza; Barzegar-Jalali, Mohammad; Barar, Jaleh; Maleki, Nasrin; Mohammadi, Ghobad; Nokhodchi, Ali

doi:10.1089/jop.2007.0039

Cited by 97 publications

(33 citation statements)

References 32 publications

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“…3(A) and (B)). The X-ray spectra of the physical mixtures exposed that the reduction in the intensity of diffraction peaks was due to dilution effect exerted by the polymer network [19,20]. Concisely, the DSC and PXRD studies verified decrease of drug crystallinity in the nanoparticles.…”

Section: Discussionmentioning

confidence: 91%

“…Only one parameter was changed in each series of experiments. Solvent evaporation/extraction technique has been applied to formulate of other anti-inflammatory drugs like piroxicam and methylprednisolone acetate [19,20].…”

Section: Discussionmentioning

confidence: 99%

“…5). Our previous studies have disclosed that the drug loading data can be obtained from release data when the drug is insoluble in water [19,20]. Since the non-encapsulated insoluble drug could not be removed from the surface of the nanoparticles during washing step.…”

Section: In Vitro Releasementioning

confidence: 99%

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Preparation and physicochemical characterization of naproxen–PLGA nanoparticles

Javadzadeh

Ahadi

Davaran

et al. 2010

Colloids and Surfaces B: Biointerfaces

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

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Preparation and physicochemical characterization of naproxen–PLGA nanoparticles

Javadzadeh

Ahadi

Davaran

et al. 2010

Colloids and Surfaces B: Biointerfaces

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“…For example, PLGA colloidal nanoparticles were exploited to deliver gene-based therapeutics to the retinal pigment epithelial cells [104] . The sustained-release nanosuspension of piroxicam and methylprednisolone acetate were formulated using Eudragit to control the endotoxininduced uveitis in rabbits [105,106] . For the treatment of chronic ocular diseases (e.g., CMV retinitis), localized prolonged nanomedicines can be used effectively as a safer alternative to the frequent injections that may cause cataract development, retinal detachment, endophthalmitis and vitreous hemorrhage [100] .…”

Section: Novelties In Ocular Drug Delivery and The Implementation Of mentioning

confidence: 99%

Ocular novel drug delivery: impacts of membranes and barriers

Barar

Javadzadeh

Omidi

2008

Expert Opinion on Drug Delivery

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Background : Ocular drug delivery is an extremely challenging area due to its restrictive barrier functionalities. Objective : Drug transport via corneal/non-corneal routes involves several intricate biological processes such as drug penetration across the ocular barriers and transfer to the anterior or posterior chambers, thus the influence of these processes on the pharmacotherapy of the eye should be fully addressed. Methods : To pursue the impacts of such impediments in novel drug therapy, recent publications were reviewed regarding advanced strategies such as nanomedicines. Conclusion : The ocular barriers are highly specialized and selectively control the inward/outward traverse of compounds, hence a better understanding of these biological obstacles would provide a platform to advance ophthalmic drug therapy towards specified delivery/targeting with minimal adverse consequences.

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“…Polymeric nanosuspensions, prepared from Eudragit RL100 and RS100, have been investigated extensively for the ocular delivery of ibuprofen (18), flurbiprofen (19), cloriocromene (20), piroxicam (21), methyl prednisolone (22), and amphotericin B (23).They are cationic copolymers of methacrylate with 4-12% quaternary ammonium groups. They are inert polymer resins, insoluble at physiologic pH but have swelling properties.…”

Section: Introductionmentioning

confidence: 99%

Preparation and physicochemical characterization of Eudragit® RL100 Nanosuspension with potential for Ocular Delivery of Sulfacetamide

Mandal

2010

J Pharm Pharm Sci

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-Purpose. Polymeric nanosuspension was prepared from an inert polymer resin (Eudragit RL100) with the aim of improving the availability of sulfacetamide at the intraocular level to combat bacterial infections. Methods. Nanosuspensions were prepared by the solvent displacement method using acetone and Pluronic F108 solution. Drug to polymer ratio was selected as formulation variable. Characterization of the nanosupension was performed by measuring particle size, zeta potential, Fourier Transform infrared spectroscopy (FTIR), Differential Scanning Calorimetry (DSC), Powder X-Ray Diffraction (PXRD), drug entrapment efficiency and in vitro release. In addition, freeze drying, redispersibility and short term stability study at room temperature and at 4 0 C were performed. Results. Spherical, uniform particles (size range below 500 nm) with positive zeta potential were obtained. No significant chemical interactionbetween drug and polymer were observed in the solid state characterization of the freeze dried nanosuspension (FDN). Drug entrapment efficiency of the selected batch was increased by pH alteration and addition of polymethyl methacrylate in the formulation. The prepared nanosuspension exhibited good stability after storage at room temperature and at 4 0 C. Sucrose and mannitol were used as cryoprotectants and exhibited good water redispersibility of the FDN. Conclusion. The results indicate that the formulation of sulfacetamide in Eudragit RL100 nanosuspension could be utilized as potential delivery system for treating ocular bacterial infections. _____________________________________________________________________________________

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Inhibition of Endotoxin-Induced Uveitis by Methylprednisolone Acetate Nanosuspension in Rabbits

Abstract: Based on our findings, we suggest that the copolymer nanosuspension may favor the localized, controlled ocular delivery of MPA for the prevention of inflammatory symptoms in ocular diseases.

Cited by 97 publications

References 32 publications

Preparation and physicochemical characterization of naproxen–PLGA nanoparticles

Preparation and physicochemical characterization of naproxen–PLGA nanoparticles

Ocular novel drug delivery: impacts of membranes and barriers

Preparation and physicochemical characterization of Eudragit® RL100 Nanosuspension with potential for Ocular Delivery of Sulfacetamide

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