Inhibition of Experimental Esophageal Lye Strictures by Penicillamine

Géhanno, P.; Guédon, C.

doi:10.1001/archotol.1981.00790390011004

Cited by 108 publications

(77 citation statements)

References 8 publications

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“…Pharmacological agents such as steroids, penicillamine, heparin, indomethacin, epidermal growth factor, gamma interferon, N-acetylcysteine, estrogen, progesterone, antibiotics, and their combinations are used to suppress inflammation and collagen synthesis, and to prevent fibroplasia and stricture formation. Despite the decrease in stricture formation in these experimental studies, the rate of stricture formation seen in advanced-grade corrosive esophagitis is still 70-100% (6)(7)(8)(14)(15)(16)(17)(18)(19)(20). Although the experimental studies have documented the efficiency of multiple agents, the current treatment protocol in corrosive esophagitis is still restricted to steroid, antibiotics and neutralization of the caustic agent in the early phase (13,(21)(22)(23)(24).…”

Section: Discussionmentioning

confidence: 99%

The efficiency of sucralfate in corrosive esophagitis: A randomized, prospective study

Gümürdülü¹,

Karakoç²,

Kara³

et al. 2010

Turk J Gastroenterol

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Section: Discussionmentioning

confidence: 99%

The efficiency of sucralfate in corrosive esophagitis: A randomized, prospective study

Gümürdülü¹,

Karakoç²,

Kara³

et al. 2010

Turk J Gastroenterol

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“…(50 mg/kg and 10 mg/kg, respectively). Caustic esophageal injury was produced using the Liu and Richardson [6] modification of the experimental model of Gehanno and Guedon [7]. Briefly, after a median laparotomy, a 1.5-cm segment of the distal esophagus was exposed, and an 8 Fr feeding catheter with an outer diameter of 0.22 cm was placed into the distal esophagus via the oral route.…”

Section: Methodsmentioning

confidence: 99%

A novel approach for preventing esophageal stricture formation: olmesartan prevented apoptosis

Dereli

Krazinski

Ayvaz

et al. 2014

Folia Histochem Cytobiol.

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Accidentally ingested corrosive substances can cause functional and structural damage to the esophageal tissue resulting in stricture formation. It has been reported that the administration of olmesartan (OLM) can have anti-inflammatory, antifibrotic and antiapoptotic effects on injured tissue. The aim of our study was to check if OLM could prevent formation of scars in the corrosive esophageal burn model. Fifty-one Wistar Albino rats were divided into six groups: Control, Sham, OLM, Sham + OLM, Burn, and Burn + OLM. Olmesartan (5 mg/kg) was given by gavage once per day for 21 consecutive days after injury. The morphology of the esophagus was assessed after Masson trichrome staining, and apoptosis was evaluated using the terminal deoxynucleotidyl transferased UTP nick end labeling (TUNEL) method. The serum nucleosomes (as an indicator of apoptosis), serum p53 protein, and esophageal tissue p53 protein levels of each group were measured by immunoassays. Muscularis mucosa damage, submucosal collagen deposition, and tunica muscularis injury in the Burn + OLM group decreased significantly compared with the Burn group (p < 0.05). Similarly, the number of apoptotic cells in the Burn + OLM group decreased compared with the Burn group (p < 0.05). Serum levels of nucleosomes and p53 and tissue of p53 protein did not differ between the groups. Exogenously administered OLM can effectively prevent the occurrence of esophageal strictures caused by corrosive esophageal burns.

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“…Animals were divided into 3 groups, each containing 10 rats. Standard esophageal corrosive burn was generated in the untreated and treated groups, as described by Gehanno and Guedon (1981). Median laparotomy incision was performed, and a 1.5-cm abdominal esophageal segment was isolated and tied both upper and lower point with 2-0 chromic catgut suture in all groups.…”

Section: Methodsmentioning

confidence: 99%

Trapidil, an Inhibitor for Phosphodiesterase and Platelet-Derived-Growth Factor, Ameliorates Corrosive Esophageal Burn in Rats

Somuncu

Çakmak

Erdoğan

et al. 2005

Tohoku J. Exp. Med.

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burn is a common health problem in the pediatric age group and causes serious esophageal injuries. The medical treatment in acute phase of corrosive esophageal injury is of particular importance for prevention of esophageal stricture. We therefore aimed to investigate the possible beneficial effect of trapidil (triazolopyrimidine), an inhibitor for phosphodiesterase and platelet-derived-growth-factor, during acute phase of esophageal corrosive injury. Wistar albino rats were randomly allocated to untreated, treated, and sham-operated groups (n = 10 for each group). Corrosive esophageal burn was generated with 10% NaOH solution. The rats were left untreated (untreated group) or treated with trapidil as a single dose of 40 mg/kg intraperitoneally after one hour of the injury (treated group). Abdominal esophageal segment was isolated and tied in sham-control group. The studied esophageal segment was removed from each animal after 24 hours. Malondialdehyde (MDA) and nitric oxide (NO) levels were measured in the esophageal tissues. The ulcer depth was graded by histopathologic examination. MDA and NO levels were significantly higher in the untreated group than in the treated group. Namely, trapidil treatment significantly decreased MDA and NO levels in the injured tissues, the levels of which are similar to those in the tissues of control animals. The grades of ulcer depth were significantly improved in the treated group. These results indicate that the reactive oxygen radicals increase in the early phase of corrosive esophagitis and cause tissue damage. We suggest that trapidil treatment may be useful in acute phase of corrosive esophageal injury. corrosive esophagitis; free oxgen radicals; trapidil; triazolopyrimidine © 2005 Tohoku University Medical PressInfants and young children often accidentally ingest corrosive substances. Ingestion of corrosive substance is a common health problem in the pediatric age group. Accidental ingestion of corrosive substances leads to serious upper aero digestive and esophageal injuries. Corrosive esophageal burns are the most common cause of esophageal stricture development (Haller et al.

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Inhibition of Experimental Esophageal Lye Strictures by Penicillamine

Cited by 108 publications

References 8 publications

The efficiency of sucralfate in corrosive esophagitis: A randomized, prospective study

The efficiency of sucralfate in corrosive esophagitis: A randomized, prospective study

A novel approach for preventing esophageal stricture formation: olmesartan prevented apoptosis

Trapidil, an Inhibitor for Phosphodiesterase and Platelet-Derived-Growth Factor, Ameliorates Corrosive Esophageal Burn in Rats

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